메뉴 건너뛰기




Volumn 31, Issue 2, 2007, Pages 252-263

Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice

Author keywords

Brain derived neurotrophic factor; Gene regulation; Insulin resistance

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 35548941431     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00093.2007     Document Type: Article
Times cited : (27)

References (37)
  • 1
    • 0034307566 scopus 로고    scopus 로고
    • Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ
    • Balkowiec A, Katz DM. Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci 20: 7417-7423, 2000.
    • (2000) J Neurosci , vol.20 , pp. 7417-7423
    • Balkowiec, A.1    Katz, D.M.2
  • 2
    • 0142074402 scopus 로고    scopus 로고
    • Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
    • Blackshear PJ, Graves JP, Stumpo DJ, Cobos I, Rubenstein JL, Zeldin DC. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development 130: 4539-4552, 2003.
    • (2003) Development , vol.130 , pp. 4539-4552
    • Blackshear, P.J.1    Graves, J.P.2    Stumpo, D.J.3    Cobos, I.4    Rubenstein, J.L.5    Zeldin, D.C.6
  • 3
    • 11144241044 scopus 로고    scopus 로고
    • Control of hyperphagia prevents obesity in BDNF heterozygous mice
    • Coppola V, Tessarollo L. Control of hyperphagia prevents obesity in BDNF heterozygous mice. Neuroreport 15: 2665-2668, 2004.
    • (2004) Neuroreport , vol.15 , pp. 2665-2668
    • Coppola, V.1    Tessarollo, L.2
  • 5
    • 0031148561 scopus 로고    scopus 로고
    • Organization, sequence and functional analysis of a mouse BDNF promoter
    • Hayes VY, Towner MD, Isackson PJ. Organization, sequence and functional analysis of a mouse BDNF promoter. Brain Res 45: 189-198, 1997.
    • (1997) Brain Res , vol.45 , pp. 189-198
    • Hayes, V.Y.1    Towner, M.D.2    Isackson, P.J.3
  • 6
    • 0025279814 scopus 로고
    • Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    • Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J 9: 2459-2464, 1990.
    • (1990) EMBO J , vol.9 , pp. 2459-2464
    • Hofer, M.1    Pagliusi, S.R.2    Hohn, A.3    Leibrock, J.4    Barde, Y.A.5
  • 7
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846, 2006.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 8
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290-1300, 2000.
    • (2000) EMBO J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 9
    • 0034204161 scopus 로고    scopus 로고
    • Rapid genome walking: A simplified oligo-cassette mediated polymerase chain reaction using a single genome-specific primer
    • Kilstrup M, Kristiansen KN. Rapid genome walking: a simplified oligo-cassette mediated polymerase chain reaction using a single genome-specific primer. Nucleic Acids Res 28: E55, 2000.
    • (2000) Nucleic Acids Res , vol.28
    • Kilstrup, M.1    Kristiansen, K.N.2
  • 10
    • 0035937575 scopus 로고    scopus 로고
    • Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons
    • Kohara K, Kitamura A, Morishima M, Tsumoto T. Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons. Science 291: 2419-2423, 2001.
    • (2001) Science , vol.291 , pp. 2419-2423
    • Kohara, K.1    Kitamura, A.2    Morishima, M.3    Tsumoto, T.4
  • 11
    • 0026625201 scopus 로고
    • BDNF and NGF treatment in lesioned rats: Effects on cholinergic function and weight gain
    • Lapchak PA, Hefti F. BDNF and NGF treatment in lesioned rats: effects on cholinergic function and weight gain. Neuroreport 3: 405-408, 1992.
    • (1992) Neuroreport , vol.3 , pp. 405-408
    • Lapchak, P.A.1    Hefti, F.2
  • 13
    • 0035106920 scopus 로고    scopus 로고
    • Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons
    • Luo XG, Rush RA, Zhou XF. Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons. Neurosci Res 39: 377-384, 2001.
    • (2001) Neurosci Res , vol.39 , pp. 377-384
    • Luo, X.G.1    Rush, R.A.2    Zhou, X.F.3
  • 16
    • 0026787928 scopus 로고
    • Insertional mutation of "classical" and novel genes in transgenic mice
    • Meisler MH. Insertional mutation of "classical" and novel genes in transgenic mice. Trends Genet 8: 341-344, 1992.
    • (1992) Trends Genet , vol.8 , pp. 341-344
    • Meisler, M.H.1
  • 17
    • 0027359034 scopus 로고
    • Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation
    • Metsis M, Timmusk T, Arenas E, Persson H. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc Natl Acad Sci USA 90: 8802-8806, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8802-8806
    • Metsis, M.1    Timmusk, T.2    Arenas, E.3    Persson, H.4
  • 23
    • 0035261381 scopus 로고    scopus 로고
    • Genomic strategies to identify mammalian regulatory sequences
    • Pennacchio LA, Rubin EM. Genomic strategies to identify mammalian regulatory sequences. Nat Rev Genet 2: 100-109, 2001.
    • (2001) Nat Rev Genet , vol.2 , pp. 100-109
    • Pennacchio, L.A.1    Rubin, E.M.2
  • 24
    • 0028466229 scopus 로고
    • Insertional mutagenesis in transgenic mice
    • Rijkers T, Peetz A, Ruther U. Insertional mutagenesis in transgenic mice. Transgenic Res 3: 203-215, 1994.
    • (1994) Transgenic Res , vol.3 , pp. 203-215
    • Rijkers, T.1    Peetz, A.2    Ruther, U.3
  • 25
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R, Lechan RM, Jaenisch R. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15: 1748-1757, 2001.
    • (2001) Mol Endocrinol , vol.15 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3    Kelly, J.4    Bates, B.5    Kuehn, R.6    Lechan, R.M.7    Jaenisch, R.8
  • 28
    • 0033005143 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice
    • Tonra JR, Ono M, Liu X, Garcia K, Jackson C, Yancopoulos GD, Wiegand SJ, Wong V. Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Diabetes 48: 588-594, 1999.
    • (1999) Diabetes , vol.48 , pp. 588-594
    • Tonra, J.R.1    Ono, M.2    Liu, X.3    Garcia, K.4    Jackson, C.5    Yancopoulos, G.D.6    Wiegand, S.J.7    Wong, V.8
  • 29
    • 33748454310 scopus 로고    scopus 로고
    • Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage
    • Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA. Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol 498: 637-648, 2006.
    • (2006) J Comp Neurol , vol.498 , pp. 637-648
    • Tran, P.V.1    Akana, S.F.2    Malkovska, I.3    Dallman, M.F.4    Parada, L.F.5    Ingraham, H.A.6
  • 30
  • 31
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 444: 875-880, 2006.
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 32
  • 33
    • 0031740793 scopus 로고    scopus 로고
    • Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure
    • Woychik RP, Alagramam K. Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure. Int J Dev Biol 42:1009-1017, 1998.
    • (1998) Int J Dev Biol , vol.42 , pp. 1009-1017
    • Woychik, R.P.1    Alagramam, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.