Live to the rhythm, slave to the rhythm

Sleep Medicine Reviews

Volumn 11, Issue 6, 2007, Pages 465-484

  Van Someren, Eus J W ^a,b   Riemersma Van Der Lek, Rixt F ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aging; Body temperature; Circadian rhythms; Corticosteroids; Entrainment; Feeding; Light; Melatonin; Peripheral oscillators; Physical activity; Regularity; Suprachiasmatic nucleus; zeitgeber

Indexed keywords

CORTICOSTEROID; HYDROCORTISONE; MELATONIN;

AGING; AMPLITUDE MODULATION; BODY TEMPERATURE; CIRCADIAN RHYTHM; CORTICAL SYNCHRONIZATION; ELECTROPHYSIOLOGY; FEEDING; HEALTH STATUS; HUMAN; NONHUMAN; OSCILLATOR; PHOTOSTIMULATION; PHYSICAL ACTIVITY; REVIEW; SLEEP; SUPRAOPTIC NUCLEUS;

ACTIVITY CYCLES; AGING; ANIMALS; BIOLOGICAL CLOCKS; BODY TEMPERATURE; CIRCADIAN RHYTHM; FEEDING BEHAVIOR; HUMANS; HYDROCORTISONE; MELATONIN; MOTOR ACTIVITY; WAKEFULNESS;

EID: 35448989992     PISSN: 10870792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smrv.2007.07.003     Document Type: Review

References (174)

1. Buijs R.M., and Kalsbeek A. Hypothalamic integration of central and peripheral clocks. Nat Rev Neurosci 2 (2001) 521-526
2. **The most important references are denoted by an asterisk. Stratmann M., and Schibler U. Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms 21 (2006) 494-506
3. *. Arendt J., and Skene D.J. Melatonin as a chronobiotic. Sleep Med Rev 9 (2005) 25-39
4. Edgar D.M., and Dement W.C. Regularly scheduled voluntary exercise synchronizes the mouse circadian clock. Am J Physiol 261 (1991) R928-R933
5. *. Van Someren E.J.W. Thermosensitivity of the circadian timing system. Sleep Biol Rhythms 1 (2003) 55-64
6. Yoo S.H., Yamazaki S., Lowrey P.L., Shimomura K., Ko C.H., Buhr E.D., et al. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. PNAS 101 (2004) 5339-5346
7. Yamazaki S., Numano R., Abe M., Hida A., Takahashi R., Ueda M., et al. Resetting central and peripheral circadian oscillators in transgenic rats. Science 288 (2000) 682-685
8. Kalsbeek A., and Buijs R.M. Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting. Cell Tissue Res 309 (2002) 109-118
9. Van Someren E.J.W. Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature. J Therm Biol 29 (2004) 437-444
10. *. Van Someren E.J.W. Mechanisms and functions of coupling between sleep and temperature rhythms. Prog Brain Res 153 (2006) 309-324
11. Desir D., Van Cauter E., Fang V.S., Martino E., Jadot C., Spire J.P., et al. Effects of "jet lag" on hormonal patterns. I. Procedures, variations in total plasma proteins, and disruption of adrenocorticotropin-cortisol periodicity. J Clin Endocrinol Metab 52 (1981) 628-641
12. Young M.E. The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function. Am J Physiol 290 (2006) H1-H16
13. Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., and Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 14 (2000) 2950-2961
14. Levi F., Misset J.L., Brienza S., Adam R., Metzger G., Itzakhi M., et al. A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer. Cancer 69 (1992) 893-900
15. Lim F.L., Currie R.A., Orphanides G., and Moggs J.G. Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review. Xenobiotica 36 (2006) 1140-1151
16. Ikeda M., Sagara M., and Inoue S. Continuous exposure to dim illumination uncouples temporal patterns of sleep, body temperature, locomotion and drinking behavior in the rat. Neurosci Lett 279 (2000) 185-189
17. Fukuhara C., Aguzzi J., Bullock N., and Tosini G. Effect of long-term exposure to constant dim light on the circadian system of rats. Neurosignals 14 (2005) 117-125
18. González M.M., and Aston-Jones G. Circadian regulation of arousal: role of the noradrenergic locus coeruleus system and light exposure. Sleep 29 (2006) 1327-1336
19. Lockley S.W., Skene D.J., Tabandeh H., Bird A.C., Defrance R., and Arendt J. Relationship between napping and melatonin in the blind. J Biol Rhythms 12 (1997) 16-25
20. Tabandeh H., Lockley S.W., Buttery R., Skene D.J., Defrance R., Arendt J., et al. Disturbance of sleep in blindness. Am J Ophthalmol 126 (1998) 707-712
21. *. Mishima K., Okawa M., Shimizu T., and Hishikawa Y. Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. J Clin Endocrinol Metab 86 (2001) 129-134
22. Hashimoto S., Kohsaka M., Nakamura K., Honma H., Honma S., and Honma K. Midday exposure to bright light changes the circadian organization of plasma melatonin rhythm in humans. Neurosci Lett 221 (1997) 89-92
23. Park S.J., and Tokura H. Bright light exposure during the daytime affects circadian rhythms of urinary melatonin and salivary immunoglobulin A. Chronobiol Int 16 (1999) 359-371
24. Kanikowska D., Hirata Y., Hyun K., and Tokura H. Acute phase proteins, body temperature and urinary melatonin under the influence of bright and dim light intensities during the daytime. J Physiol Anthropol Appl Hum Sci 20 (2001) 333-338
25. Lucassen P.J., Hofman M.A., and Swaab D.F. Increased light intensity prevents the age related loss of vasopressin-expressing neurons in the rat suprachiasmatic nucleus. Brain Res 693 (1995) 261-266
26. Witting W., Mirmiran M., Bos N.P., and Swaab D.F. Effect of light intensity on diurnal sleep-wake distribution in young and old rats. Brain Res Bull 30 (1993) 157-162
27. Weinert D., Weinert H., and Sturm J. Internal and external desynchronization in old mice; effect of zeitgeber strength. Biol Rhythm Res 30 (1999) 279
28. Honma K.I., and Hiroshige T. Endogenous ultradian rhythms in rats exposed to prolonged continuous light. Am J Physiol 235 (1978) R250-R256
29. Simon N., Vidal J., Mouchet J., and Bruguerolle B. Lack of daily rhythms major modifications despite continuous infusion of melatonin in the rat. J Vet Pharmacol Ther 25 (2002) 285-288
30. Haimov I., Laudon M., Zisapel N., Souroujon M., Nof D., Shlitner A., et al. Sleep disorders and melatonin rhythms in elderly people. Br Med J 309 (1994) 167
31. Hajak G., Rodenbeck A., Staedt J., Bandelow B., Huether G., and Rüther E. Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia. J Pineal Res 19 (1995) 116-122
32. Riemann D., Klein T., Rodenbeck A., Feige B., Horny A., Hummel R., et al. Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiat Res 113 (2002) 17-27
33. Shilo L., Dagan Y., Smorjik Y., Weinberg U., Dolev S., Komptel B., et al. Patients in the intensive care unit suffer from severe lack of sleep associated with loss of normal melatonin secretion pattern. Am J Med Sci 317 (1999) 278-281
34. Winget C.M., Vernikos-Danellis J., Cronin S.E., Leach C.S., Rambaut P.C., and Mack P.B. Circadian rhythm asynchrony in man during hypokinesis. J Appl Physiol 33 (1972) 640-643
35. Campbell S.S. Duration and placement of sleep in a "disentrained" environment. Psychophysiology 21 (1984) 106-113
36. Golja P., Eiken O., Rodman S., Sirok B., and Mekjavic I.B. Core temperature circadian rhythm during 35 days of horizontal bed rest. J Gravit Physiol 9 (2002) 187-188
37. Yeo S., and Scarbough M. Exercise-induced hyperthermia may prevent accurate core temperature measurement by tympanic membrane thermometer. J Nurs Meas 4 (1996) 143-151
38. Swaab D.F., Fliers E., and Partiman T.S. The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 342 (1985) 37-44
39. Liu R.Y., Zhou J.N., Hoogendijk W.J.G., Van Heerikhuize J., Kamphorst W., Unmehopa U.A., et al. Decreased vasopressin gene expression in the biological clock of Alzheimer's disease patients with and without depression. J Neuropathol Exp Neurol 59 (2000) 314-322
40. Van Someren E.J.W., Lazeron R.H.C., Vonk B.F.M., Mirmiran M., and Swaab D.F. Gravitational artefact in frequency spectra of movement acceleration: implications for actigraphy in young and elderly subjects. J Neurosci Methods 65 (1996) 55-62
41. *. Van Someren E.J.W. Improving actigraphic sleep estimates: how many nights?. J Sleep Res 16 (2007) 269-275
42. Van Someren E.J.W., Van Gool W.A., Vonk B.F.M., Mirmiran M., Speelman J.D., Bosch D.A., et al. Ambulatory monitoring of tremor and other movements before and after thalamotomy: a new quantitative technique. J Neurol Sci 117 (1993) 16-23
43. Van Someren E.J.W., Vonk B.F.M., Thijssen W., Speelman J.D., Schuurman P.R., Mirmiran M., et al. A new actigraph for long-term registration of the duration and intensity of tremor and movement. IEEE Trans Biomed Eng 45 (1998) 386-395
44. Van Someren E.J.W., Pticek M.D., Speelman J.D., Schuurman P.R., Esselink R., and Swaab D.F. A new actigraph for long-term tremor recording. Mov Disord 21 (2006) 1136-1143
45. Van Someren E.J.W., Hagebeuk E.E.O., Lijzenga C., Scheltens P., De Rooij S.E.J.A., Jonker C., et al. Circadian rest-activity rhythm disturbances in Alzheimer's disease. Biol Psychiat 40 (1996) 259-270
46. Sullivan S.C., and Richards K.C. Predictors of circadian sleep-wake rhythm maintenance in elders with dementia. Aging Ment Health 8 (2004) 143-152
47. Werth E., Savaskan E., Knoblauch V., Fontana Gasio P., Van Someren E.J.W., Hock C., et al. Decline in long-term circadian rest-activity cycle organization in a patient with dementia. J Geriat Psychiat Neurol 15 (2002) 55-59
48. *. Mormont M.C., Waterhouse J., Bleuzen P., Giacchetti S., Jami A., Bogdan A., et al. Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status. Clin Cancer Res 6 (2000) 3038-3045
49. Mormont M.C., and Waterhouse J. Contribution of the rest-activity circadian rhythm to quality of life in cancer patients. Chronobiol Int 19 (2002) 313-323
50. Morgan K., and Clarke D. Risk factors for late-life insomnia in a representative general practice sample. Br J Gen Pract 47 (1997) 166-169
51. Gehrman P., Marler M., Martin J.L., Shochat T., Corey-Bloom J., and Ancoli-Israel S. The timing of activity rhythms in patients with dementia is related to survival. J Gerontol Med Sci 59 (2004) 1050-1055
52. Brown S.A., Zumbrunn G., Fleury-Olela F., Preitner N., and Schibler U. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol 12 (2002) 1574-1583
53. Souêtre E., Salvati E., Belugou J.L., Pringuey D., Candito M., Krebs B., et al. Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality. Psychiat Res 28 (1989) 263-278
54. Pruessner J.C., Hellhammer D.H., and Kirschbaum C. Burnout, perceived stress, and cortisol responses to awakening. Psychosom Med 61 (1999) 197-204
55. Scheer F.A.J.L., Van Paassen B., Van Montfrans G.A., Fliers E., Van Someren E.J.W., Van Heerikhuize J.J., et al. Human basal cortisol levels are increased in hospital compared to home setting. Neurosci Lett 333 (2002) 79-82
56. Van Cauter E., Leproult R., and Kupfer D.J. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab 81 (1996) 2468-2473
57. Scherder E., Knol D., Van Someren E.J.W., Deijen J., Binnekade R., Tilders F., et al. Effects of cranial electrostimulation on the rest-activity rhythm and salivary cortisol in Alzheimer's disease. Neurorehab Neural Repair 17 (2003) 101-108
58. Hatfield C.F., Herbert J., Van Someren E.J.W., Hodges J.R., and Hastings M.H. Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia. Brain 127 (2004) 1061-1074
59. Cain S.W., Karatsoreos I., Gautam N., Konar Y., Funk D., McDonald R.J., et al. Blunted cortisol rhythm is associated with learning impairment in aged hamsters. Physiol Behav 82 (2004) 339-344
60. Sephton S.E., Sapolsky R.M., Kraemer H.C., and Spiegel D. Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst 92 (2000) 994-1000
61. Mendoza J. Circadian clocks: setting time by food. J Neuroendocrinol 19 (2007) 127-137
62. Gerkema M.P., Daan S., Wilbrink M., Hop M.W., and van der Leest F. Phase control of ultradian feeding rhythms in the common vole (Microtus arvalis): the roles of light and the circadian system. J Biol Rhythms 8 (1993) 151-171
63. Van Someren E.J.W., and Nagtegaal E. Improving melatonin circadian phase estimates. Sleep Med 8 (2007) 590-601
64. van der Veen D.R., Minh N.L., Gos P., Arneric M., Gerkema M.P., and Schibler U. Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. PNAS 103 (2006) 3393-3398
65. Huang Y.-L., Liu R.-Y., Wang Q.-S., Van Someren E.J.W., Xu H., and Zhou J.-N. Age-associated difference in circadian sleep-wake and rest-activity rhythms. Physiol Behav 76 (2002) 597-603
66. *. Cayetanot F., Van Someren E.J.W., Perret M., and Aujard F. Shortened seasonal photoperiodic cycles accelerate aging of the diurnal and circadian locomotor activity rhythms in a primate. J Biol Rhythms 20 (2005) 661-669
67. Van Someren E.J.W., Swaab D.F., Colenda C.C., Cohen W., McCall W.V., and Rosenquist P.B. Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods. Chronobiol Int 16 (1999) 505-518
68. Carvalho-Bos S., Riemersma-van der Lek R.F., Waterhouse J., Reilly T., and Van Someren E.J.W. Strong association of the rest-activity rhythm with well-being in demented elderly women. Am J Geriatr Psychiat 15 (2007) 92-100
69. Raymann R.J.E.M., Swaab D.F., and Van Someren E.J.W. Cutaneous warming promotes sleep onset. Am J Physiol 288 (2005) R1589-R1597
70. Raymann R.J.E.M., and Van Someren E.J.W. Time-on-task impairment of psychomotor vigilance is affected by mild skin warming and changes with aging and insomnia. Sleep 30 (2007) 96-103
71. Bao A.-M., Liu R.-Y., Van Someren E.J.W., Hofman M.A., Cao Y.-X., and Zhou J.-N. Diurnal rhythm of free estradiol during the menstrual cycle. Eur J Endocrinol 148 (2003) 227-232
72. Bao A.-M., Hestiantoro A., Van Someren E.J.W., Swaab D.F., and Zhou J.-N. Colocalization of corticotropin-releasing hormone and oestrogen receptor-α in the paraventricular nucleus of the hypothalamus in mood disorders. Brain 128 (2005) 1301-1313
73. Bao A.-M., Ji Y.-F., Van Someren E.J.W., Hofman M.A., Chu X.-H., Liu R.-Y., et al. Diurnal rhythms of free estradiol and cortisol during the normal menstrual cycle in women with major depression. Horm Behav 45 (2004) 93-102
74. Hartmann A., Veldhuis J.D., Deuschle M., Standhardt H., and Heuser I. Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol Aging 18 (1997) 285-289
75. Maywood E.S., O'Neill J., Wong G.K., Reddy A.B., and Hastings M.H. Circadian timing in health and disease. Prog Brain Res 153 (2006) 253-269
76. Li H., and Satinoff E. Changes in circadian rhythms of body temperature and sleep in old rats. Am J Physiol 269 (1995) R208-R214
77. Satinoff E. Patterns of circadian body temperature rhythms in aged rats. Clin Exp Pharmacol Physiol 25 (1998) 135-140
78. Froy O., Chapnik N., and Miskin R. Long-lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms. Am J Physiol 291 (2006) E1017-E1024
79. Conti B., Sanchez-Alavez M., Winsky-Sommerer R., Morale M.C., Lucero J., Brownell S., et al. Transgenic mice with a reduced core body temperature have an increased life span. Science 314 (2006) 825-828
80. Penev P.D., Kolker D.E., Zee P.C., and Turek F.W. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease. Am J Physiol 275 (1998) H2334-H2337
81. *. Davidson A.J., Sellix M.T., Daniel J., Yamazaki S., Menaker M., and Block G.D. Chronic jet-lag increases mortality in aged mice. Curr Biol 16 (2006) R914-R916
82. Akerstedt T. Altered sleep/wake patterns and mental performance. Physiol Behav 90 (2007) 209-218
83. Harma M. Individual differences in tolerance to shiftwork: a review. Ergonomics 36 (1993) 101-109
84. Cho K., Ennaceur A., Cole J.C., and Suh C.K. Chronic jet lag produces cognitive deficits. J Neurosci 20 (2000) RC66
85. *. Cho K. Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits. Nat Neurosci 4 (2001) 567-568
86. Fukuda K., Ishhara K., Takeuchi T., Yamamoto Y., and Inugami M. Core temperature pattern and self-rated lifestyle. Psychiat Clin Neurosci 52 (1998) 243-245
87. Minors D.S., and Waterhouse J.M. The role of naps in alleviating sleepiness during an irregular sleep-wake schedule. Ergonomics 30 (1987) 1261-1273
88. Aujard F., Dkhissi-Benyahya O., Fournier I., Claustrat B., Schilling A., Cooper H.M., et al. Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus. Neuroscience 105 (2001) 403-412
89. Hofman M.A., and Swaab D.F. Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res 651 (1994) 134-142
90. Wu Y.H., Fischer D.F., Kalsbeek A., Garidou-Boof M.L., van der Vliet J., van Heijningen C., et al. Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock". FASEB J 20 (2006) 1874-1876
91. Yamazaki S., Straume M., Tei H., Sakaki Y., Menaker M., and Block G.D. Effects of aging on central and peripheral mammalian clocks. PNAS 99 (2002) 10801-10806
92. Satlin A., Volicer L., Stopa E.G., and Harper D. Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease. Neurobiol Aging 16 (1995) 765-771
93. Riemersma R.F., Mattheij C.A.M., Swaab D.F., and Van Someren E.J.W. Melatonin rhythms, melatonin supplementation and sleep in old age. In: Straub R.H., and Mocchegiani E. (Eds). The neuroendocrine immune network in ageing (2004), Elsevier, Amsterdam 195-211
94. Van Someren E.J.W., Riemersma R.F., and Swaab D.F. Functional plasticity of the circadian timing system in old age: light exposure. Prog Brain Res 138 (2002) 205-231
95. Van Someren E.J.W., Raymann R.J.E.M., Scherder E.J.A., Daanen H.A.M., and Swaab D.F. Circadian and age-related modulation of thermoreception and temperature regulation: mechanisms and functional implications. Ageing Res Rev 1 (2002) 721-778
96. Minors D., Rabbitt P.M.A., Worthington H., and Waterhouse J. Variation in meals and sleep-activity patterns in aged subjects; its relevance to circadian rhythm studies. Chronobiol Int 6 (1989) 139-146
97. Minors D., Atkinson G., Bent N., Rabbitt P., and Waterhouse J. The effects of age upon some aspects of lifestyle and implications for studies on circadian rhythmicity. Age Ageing 27 (1998) 67-72
98. Monk T.H., Reynolds III C.F., Kupfer D.J., Hoch C.C., Carrier J., and Houck P.R. Differences over the life span in daily life-style regularity. Chronobiol Int 14 (1997) 295-306
99. Monk T.H., Buysse D.J., Hall M., Nofzinger E.A., Thompson W.K., Mazumdar S.A., et al. Age-related differences in the lifestyle regularity of seniors experiencing bereavement, care-giving, insomnia, and advancement into old-old age. Chronobiol Int 23 (2006) 831-841
100. Monk T.H., Reynolds III C.F., Buysee D.J., DeGrazia J.M., and Kupfer D.J. The relationship between lifestyle regularity and subjective sleep quality. Chronobiol Int 20 (2003) 97-107
101. Monk T.H., Petrie S.R., Hayes A.J., and Kupfer D.J. Regularity of daily life in relation to personality, age, gender, sleep quality and circadian rhythms. J Sleep Res 3 (1994) 196-205
102. Lieberman H.R., Wurtman J.J., and Teicher M.H. Circadian rhythms of activity in healthy young and elderly humans. Neurobiol Aging 10 (1989) 259-265
103. Monk T.H. Aging human circadian rhythms: conventional wisdom may not always be right. J Biol Rhythms 20 (2005) 366-374
104. Rosenthal N.E., Sack D.A., Gillin J.C., Lewy A.J., Goodwin F.K., Davenport Y., et al. Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 41 (1984) 72-80
105. Wirz-Justice A. Light therapy for depression: present status, problems, and perspectives. Psychopathology 19 Suppl. 2 (1986) 136-141
106. Wirz-Justice A. Beginning to see the light. Arch Gen Psychiatry 55 (1998) 861-862
107. Okawa M., Mishima K., Shimizu T., Iijima S., Hishikawa Y., Hozumi S., et al. Sleep-wake rhythm disorders and their phototherapy in elderly patients with dementia. Jpn J Psychiatry Neurol 43 (1989) 293-295
108. Okawa M., Hishikawa Y., Hozumi S., and Hori H. Sleep-wake disorder and phototherapy in elderly patients with dementia. In: Racagni G. (Ed). Biological psychiatry (1991), Elsevier, Amsterdam 837-840
109. Satlin A., Volicer L., Ross V., Herz L., and Campbell S. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease. Am J Psychiatry 149 (1992) 1028-1032
110. Van Someren E.J.W., Kessler A., Mirmiran M., and Swaab D.F. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol Psychiatry 41 (1997) 955-963
111. Mirmiran M., Van Someren E.J.W., and Swaab D.F. Is brain plasticity preserved during aging and in Alzheimer's disease?. Behav Brain Res 78 (1996) 43-48
112. Dowling G.A., Hubbard E.M., Mastick J., Luxenberg J.S., Burr R.L., and Van Someren E.J.W. Effect of morning bright light treatment for rest-activity disruption in institutionalized patients with severe Alzheimer's disease. Int Psychogeriatr 17 (2005) 221-236
113. Murphy P.J., and Campbell S.S. Enhanced performance in elderly subjects following bright light treatment of sleep maintenance insomnia. J Sleep Res 5 (1996) 165-172
114. Sörensen S., and Brunnström G. Quality of light and quality of life: an intervention study among older people. Light Res Technol 27 (1995) 113-118
115. Wirz-Justice A., Graw P., Krauchi K., Sarrafzadeh A., English J., Arendt J., et al. 'Natural' light treatment of seasonal affective disorder. J Affect Disord 37 (1996) 109-120
116. Rosenwasser A.M., Boulos Z., and Terman M. Circadian feeding and drinking rhythms in the rat under complete and skeleton photoperiods. Physiol Behav 30 (1983) 353-359
117. Comas M., Beersma D.G., Spoelstra K., and Daan S. Phase and period responses of the circadian system of mice (Mus musculus) to light stimuli of different duration. J Biol Rhythms 21 (2006) 362-372
118. Hebert M., Martin S.K., Lee C., and Eastman C.I. The effects of prior light history on the suppression of melatonin by light in humans. J Pineal Res 33 (2002) 198-203
119. *. Eastman C.I., Young M.A., Fogg L.F., Liu L., and Meaden P.M. Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry 55 (1998) 883-889
120. *. Terman M., Terman J.S., and Ross D.C. A controlled trial of timed bright light and negative air ionization for treatment of winter depression. Arch Gen Psychiatry 55 (1998) 875-882
121. Boulos Z., and Macchi M.M. Season- and latitude-dependent effects of simulated twilights on circadian entrainment. J Biol Rhythms 20 (2005) 132-144
122. *. Fontana Gasio P., Kräuchi K., Cajochen C., Van Someren E.J.W., Amrhein I., Pache M., et al. Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly. Exp Gerontol 38 (2003) 207-216
123. Van Der Heijden K.B., Smits M.G., Van Someren E.J.W., and Gunning W.B. Prediction of melatonin efficacy by pre-treatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia. J Sleep Res 14 (2005) 187-194
124. Van Der Heijden K.B., Smits M.G., Van Someren E.J.W., Ridderinkhof K.R., and Gunning W.B. Effect of melatonin on sleep, behavior and cognition in ADHD and chronic sleep onset insomnia. J Am Acad Child Adoles Psychiatry 46 (2007) 233-241
125. *. Chesworth M.J., Cassone V.M., and Armstrong S.M. Effects of daily melatonin injections on activity rhythms of rats in constant light. Am J Physiol 253 (1987) R101-R107
126. *. Kunz D. Chronobiotic protocol and circadian sleep propensity index: new tools for clinical routine and research on melatonin and sleep. Pharmacopsychiatry 37 (2004) 139-146
127. Kunz D., Mahlberg R., Muller C., Tilmann A., and Bes F. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol Metab 89 (2004) 128-134
128. Scheer F.A.J.L., Van Montfrans G.A., Van Someren E.J.W., Mairuhu G., and Buijs R.M. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 43 (2004) 192-197
129. Armstrong S.M., and Redman J.R. Melatonin: a chronobiotic with anti-aging properties?. Med Hypotheses 34 (1991) 300-309
130. Benloucif S., Guico M.J., Reid K.J., Wolfe L.F., L'Hermite-Baleriaux M., and Zee P.C. Stability of melatonin and temperature as circadian phase markers and their relation to sleep times in humans. J Biol Rhythms 20 (2005) 178-188
131. *. De Boer T., Detari L., and Meijer J.H. Long-term effects of sleep deprivation on the mammalian circadian pacemaker. Sleep 30 (2007) 27-262
132. Manber R., Bootzin R.R., Acebo C., and Carskadon M.A. The effects of regularizing sleep-wake schedules on daytime sleepiness. Sleep 19 (1996) 432-441
133. Bonnet M.H., and Alter J. Effects of irregular versus regular sleep schedules on performance, mood and body temperature. Biol Psychol 14 (1982) 287-296
134. *. Atkinson G., Edwards B., Reilly T., and Waterhouse J. Exercise as a synchroniser of human circadian rhythms: an update and discussion of the methodological problems. Eur J Appl Physiol 99 (2007) 331-341
135. Miyazaki T., Hashimoto S., Masubuchi S., Honma S., and Honma K.I. Phase-advance shifts of human circadian pacemaker are accelerated by daytime physical exercise. Am J Physiol 281 (2001) R197-R205
136. Yamanaka Y., Honma K.I., Hashimoto S., Takasu N., Miyazaki T., and Honma S. Effects of physical exercise on human circadian rhythms. Sleep Biol Rhythms 4 (2006) 199-206
137. Driver H.S., and Taylor S.R. Exercise and sleep. Sleep Med Rev 4 (2000) 387-402
138. Vuori I., Urponen H., Hasan J., and Partinen M. Epidemiology of exercise effects on sleep. Acta Paediatr Scand Suppl 574 (1988) 3-7
139. Sherrill D.L., Kotchou K., and Quan S.F. Association of physical activity and human sleep disorders. Arch Intern Med 158 (1998) 1894-1898
140. Kubitz K.A., Landers D.M., Petruzzello S.J., and Han M. The effects of acute and chronic exercise on sleep. A meta-analytic review. Sports Med 21 (1996) 277-291
141. Youngstedt S.D., O'Connor P.J., and Dishman R.K. The effects of acute exercise on sleep: a quantitative synthesis. Sleep 20 (1997) 203-214
142. Tworoger S.S., Yasui Y., Vitiello M.V., Schwartz R.S., Ulrich C.M., Aiello E.J., et al. Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women. Sleep 26 (2003) 830-836
143. Mistlberger R.E. Effects of daily schedules of forced activity on free-running rhythms in the rat. J Biol Rhythms 6 (1991) 71-80
144. Marchant E.G., and Mistlberger R.E. Entrainment and phase shifting of circadian rhythms in mice by forced treadmill running. Physiol Behav 60 (1996) 657-663
145. Van Someren E.J.W., Lijzenga C., Mirmiran M., and Swaab D.F. Long-term fitness training improves the circadian rest-activity rhythm in healthy elderly males. J Biol Rhythms 12 (1997) 146-156
146. King A.C., Oman R.F., Brassington G.S., Bliwise D.L., and Haskell W.L. Moderate-intensity exercise and self-rated quality of sleep in older adults. A randomized controlled trial [see comments]. JAMA 277 (1997) 32-37
147. Benloucif S., Orbeta L., Ortiz R., Janssen I., Finkel S.I., Bleiberg J., et al. Morning or evening activity improves neuropsychological performance and subjective sleep quality in older adults. Sleep 27 (2004) 1542-1551
148. Tsai L-L, Tsai Y-C. The effect of scheduled forced wheel activity on body weight in male F344 rats undergoing chronic circadian desynchronization. Int J Obes 2007 [advance online publication, 13 March 2007; doi:10.1038/sj.ijo.0803607].
149. Kramer A.F., Hahn S., Cohen N.J., Banich M.T., McAuley E., Harrison C.R., et al. Ageing, fitness and neurocognitive function. Nature 400 (1999) 418-419
150. Colcombe S.J., Kramer A.F., Erickson K.I., Scalf P., McAuley E., Cohen N.J., et al. Cardiovascular fitness, cortical plasticity, and aging. PNAS 101 (2004) 3316-3321
151. Mirmiran M., and Van Someren E. The importance of REM sleep for brain maturation. J Sleep Res 2 (1993) 188-192
152. Walker M.P., and Stickgold R. Sleep-dependent learning and memory consolidation. Neuron 44 (2004) 121-133
153. Rensing L., and Ruoff P. Temperature effect on entrainment, phase shifting, and amplitude of circadian clocks and its molecular bases. Chronobiol Int 19 (2002) 807-864
154. Van Marken Lichtenbelt W.D., Daanen H.A.M., Wouters L., Fronczek R., Raymann R.J.E.M., Severens N.M.W., et al. Evaluation of wireless determination of skin temperature using iButtons. Physiol Behav 88 (2006) 489-497
155. Raymann R.J.E.M., Swaab D.F., and Van Someren E.J.W. Skin temperature and sleep-onset latency: changes with age and insomnia. Physiol Behav 90 (2007) 257-266
156. Fronczek R., Overeem S., Lammers G.J., Van Dijk J.G., and Van Someren E.J.W. Altered skin temperature regulation in narcolepsy relates to sleep propensity. Sleep 29 (2006) 1444-1449
157. Pache M., Krauchi K., Cajochen C., Wirz-Justice A., Dubler B., Flammer J., et al. Cold feet and prolonged sleep-onset latency in vasospastic syndrome. Lancet 358 (2001) 125-126
158. Scheer F.A.J.L., van Heijningen C., Van Someren E.J.W., and Buijs R.M. Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature. Neuroscience 132 (2005) 465-477
159. *. Van der Helm-Van Mil A.H.M., Van Someren E.J.W., Van den Boom R., Van Buchem M.A., De Craen A.J.M., and Blauw G.J. No influence of melatonin on cerebral blood flow in humans. J Clin Endocrinol Metab 88 (2003) 5989-5994
160. Wust S., Wolf J., Hellhammer D.H., Federenko I., Schommer N., and Kirschbaum C. The cortisol awakening response-normal values and confounds. Noise Health 2 (2000) 79-88
161. Scheer F.A., and Buijs R.M. Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab 84 (1999) 3395-3398
162. Waterhouse J., Minors D., Atkinson G., and Benton D. Chronobiology and meal times: internal and external factors. Br J Nutr 77 Suppl. 1 (1997) S29-S38
163. Gibney M.J., and Wolever T.M. Periodicity of eating and human health: present perspective and future directions. Br J Nutr 77 Suppl. 1 (1997) S3-S5
164. Schlettwein G., and Barclay D. Longitudinal changes in dietary habits and attitudes of elderly Europeans. SENECA Investigators. Eur J Clin Nutr 50 Suppl. 2 (1996) S56-S66
165. Mistlberger R.E., and Skene D.J. Social influences on mammalian circadian rhythms: animal and human studies. Biol Rev Camb Philos Soc 79 (2004) 533-556
166. De Boer T., Vansteensel M.J., Detari L., and Meijer J.H. Sleep states alter activity of suprachiasmatic nucleus neurons. Nat Neurosci 6 (2003) 1086-1090
167. Van Someren E.J.W., Scherder E.J.A., and Swaab D.F. Transcutaneous electrical nerve stimulation (TENS) improves circadian rhythm disturbances in Alzheimer's disease. Alzheimer Dis Assoc Disord 12 (1998) 114-118
168. Scherder E.J.A., Van Someren E.J.W., and Swaab D.F. Transcutaneous Electrical Nerve Stimulation (TENS) improves the rest-activity rhythm in midstage Alzheimer's disease. Behav Brain Res 101 (1999) 105-107
169. Scherder E.J.A., Van Someren E.J., Bouma A., and Van Den Berg M. Effects of transcutaneous electrical nerve stimulation (TENS) on cognition and behaviour in aging. Behav Brain Res 111 (2000) 223-225
170. Holloway F.A., and Wansley R.A. Multiple retention deficits at periodic intervals after active and passive avoidance learning. Behav Biol 9 (1973) 1-14
171. Biemans B.A., Van der Zee E.A., and Daan S. Age-dependent effects of conditioning on cholinergic and vasopressin systems in the rat suprachiasmatic nucleus. Biol Chem 384 (2003) 729-736
172. Meijer J.H., and Schwartz W.J. In search of the pathways for light-induced pacemaker resetting in the suprachiasmatic nucleus. J Biol Rhythms 18 (2003) 235-249
173. Meijer J.H., Michel S., and Vansteensel M.J. Processing of daily and seasonal light information in the mammalian circadian clock. Gen Comp Endocrinol (2007)
174. To T.L., Henson M.A., Herzog E.D., and Doyle III F.J. A molecular model for intercellular synchronization in the mammalian circadian clock. Biophys J (2007)