IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance

Biochemical and Biophysical Research Communications

Volumn 364, Issue 2, 2007, Pages 301-307

  Murata, Yusuke ^a   Tsuruzoe, Kaku ^a   Kawashima, Junji ^a   Furukawa, Noboru ^a   Kondo, Tatsuya ^a   Motoshima, Hiroyuki ^a   Igata, Motoyuki ^a   Taketa, Kayo ^a   Sasaki, Kazunari ^a   Kishikawa, Hideki ^a   Kahn, C Ronald ^b   Toyonaga, Tetsushi ^a   Araki, Eiichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Insulin resistance; IRS 1; TNF

Indexed keywords

COMPLEMENTARY DNA; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS FAT; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ADIPOSE TISSUE; ANIMALS; EPIDIDYMIS; GLUCOSE; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

MUS; MUS MUSCULUS;

EID: 35448958852     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.007     Document Type: Article

References (19)

1. Taniguchi C.M., Emanuelli B., and Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat. Rev. Mol. Cell Biol. 7 (2006) 85-96
2. Saltiel A.R., and Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414 (2001) 799-806
3. Sun X.J., Rothenberg P., Kahn C.R., Backer J.M., Araki E., Wilden P.A., Cahill D.A., Goldstein B.J., and White M.F. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352 (1991) 73-77
4. Araki E., Lipes M.A., Patti M.E., Bruning J.C., Haag III B., Johnson R.S., and Kahn C.R. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372 (1994) 186-190
5. Tamemoto H., Kadowaki T., Tobe K., Yagi T., Sakura H., Hayakawa T., Terauchi Y., Ueki K., Kaburagi Y., Satoh S., et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372 (1994) 182-186
6. Shirakami A., Toyonaga T., Tsuruzoe K., Shirotani T., Matsumoto K., Yoshizato K., Kawashima J., Hirashima Y., Miyamura N., Kahn C.R., and Araki E. Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes. J. Endocrinol. 174 (2002) 309-319
7. Rondinone C.M., Wang L.M., Lonnroth P., Wesslau C., Pierce J.H., and Smith U. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA 94 (1997) 4171-4175
8. Anai M., Funaki M., Ogihara T., Terasaki J., Inukai K., Katagiri H., Fukushima Y., Yazaki Y., Kikuchi M., Oka Y., and Asano T. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 47 (1998) 13-23
9. Kerouz N.J., Horsch D., Pons S., and Kahn C.R. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J. Clin. Invest. 100 (1997) 3164-3172
10. Yoshimura R., Araki E., Ura S., Todaka M., Tsuruzoe K., Furukawa N., Motoshima H., Yoshizato K., Kaneko K., Matsuda K., Kishikawa H., and Shichiri M. Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling. Diabetes 46 (1997) 929-936
11. Araki E., Kahn C.R., and Shichiri M. Characterization of the IRS-1 (insulin receptor substrate-1) gene and its promoter. Nippon Rinsho 52 (1994) 2659-2664
12. Matsuda K., Araki E., Yoshimura R., Tsuruzoe K., Furukawa N., Kaneko K., Motoshima H., Yoshizato K., Kishikawa H., and Shichiri M. Cell-specific regulation of IRS-1 gene expression: role of E box and C/EBP binding site in HepG2 cells and CHO cells. Diabetes 46 (1997) 354-362
13. Cho H., Mu J., Kim J.K., Thorvaldsen J.L., Chu Q., Crenshaw III E.B., Kaestner K.H., Bartolomei M.S., Shulman G.I., and Birnbaum M.J. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292 (2001) 1728-1731
14. Ross J. mRNA stability in mammalian cells. Microbiol. Rev. 59 (1995) 423-450
15. Pete G., Fuller C.R., Oldham J.M., Smith D.R., D'Ercole A.J., Kahn C.R., and Lund P.K. Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice. Endocrinology 140 (1999) 5478-5487
16. Miki H., Yamauchi T., Suzuki R., Komeda K., Tsuchida A., Kubota N., Terauchi Y., Kamon J., Kaburagi Y., Matsui J., Akanuma Y., Nagai R., Kimura S., Tobe K., and Kadowaki T. Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. Mol. Cell Biol. 21 (2001) 2521-2532
17. Tseng Y.H., Kriauciunas K.M., Kokkotou E., and Kahn C.R. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol. Cell Biol. 24 (2004) 1918-1929
18. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
19. Hotamisligil G.S., Murray D.L., Choy L.N., and Spiegelman B.M. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. USA 91 (1994) 4854-4858