Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor α1 subunit: Critical residues for activation and modulation

Biochemistry

Volumn 43, Issue 31, 2004, Pages 10058-10063

  Schofield, Claude M ^a,c   Trudell, James R ^d   Harrison, Neil L ^b,c  

^a Graduate Program in Neuroscience   (United States)

^b Department of Anesthesiology ^*  (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETICS; ELECTRIC CURRENTS; HYDROPHOBICITY; IONS; MODULATION; SURFACE PROPERTIES; TRANSCEIVERS;

ALANINE-SCANNING MUTAGENESIS; DISULFIDE LOOPS; GLYCINE RECEPTORS; POSTSYNAPTIC CURRENTS;

MUTAGENESIS;

ALANINE; AMINO ACID; DISULFIDE; GLYCINE RECEPTOR; HALOTHANE; ISOFLURANE; NEUROTRANSMITTER; TAURINE;

ARTICLE; HUMAN; HUMAN CELL; MODULATION; MOLECULAR MODEL; MUTATION; PATCH CLAMP; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ALANINE; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ASPARTIC ACID; CELL LINE; CONSERVED SEQUENCE; CYSTEINE; DISULFIDES; HUMANS; LEUCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROLINE; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, GLYCINE; TRYPTOPHAN;

PROKARYOTA;

EID: 3543083927     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036159g     Document Type: Article

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