Structure and function of a minimal receptor activation domain of parathyroid hormone

Yonsei Medical Journal

Volumn 45, Issue 3, 2004, Pages 419-427

  Lee, Eun Jin ^a   Kim, Hai Young ^b   Cho, Min Kyu ^b   Lee, Weontae ^b   Lim, Sung Kil ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Cyclic AMP generating activity; Nuclear magnetic resonance; Parathyroid hormone; Parathyroid hormone receptor; helix

Indexed keywords

ALANINE; ARGININE; CYCLIC AMP; LEUCINE; LYSINE; OLIGOPEPTIDE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE[1-11]; PEPTIDE DERIVATIVE; PHENYLALANINE; RECOMBINANT HORMONE; RECOMBINANT PARATHYROID HORMONE; SERINE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; HUMAN; MOLECULAR SIZE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 3543010193     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2004.45.3.419     Document Type: Article

References (30)

1. Potts JT Jr, Bringhurst FR, Gardella T, Nussbaum S, Serge G, Kronenberg H. Williams' Textbook of Endocrinology. In: Williams RH, Wilson JD, Forster DW, editors. Philadelphia: W.B. Saunders Co.; 1995. p.920-66.
2. Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science 2000;289:1508-14.
3. Bisello A, Adams AE, Mierke DF, Pellegrini M, Rosenblatt M, Suva LJ, et al. Parathyroid hormone-receptor interactions identified directly by photocrosslinking and molecular modeling studies. J Biol Chem 1998;273:22498-505.
4. Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, et al. Crystal Structure of human parathyroid hormone 1-34 at 0.9-Å resolution. J Biol Chem 2000;275:27238-44.
5. Pellegrini M, Royo M, Rosenblatt M, Chorev M, Mierke DF. Addressing the tertiary structure of human parathyroid hormone-(1-34). J Biol Chem 1998;273:10420-7.
6. Mannstadt M, Juppner H, Gardella TJ. Receptors for PTH and PTHrp: their biological importance and functional properties. Am Physiol Soc (Invited Review) 1999. p.F665-75.
7. Hoare SR Jr, Clark JA, Usdin TB. Molecular determinants of tuberoinfundibular peptide of 39 residue (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor (N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity). J Biol Chem 2000;275:27274-83.
8. Usdin TB, Wang T, Hoare SR Jr, Mezey E, Palkovits M. New members of the parathyroid hormone/parathyroid, hormone receptor family: The parathyroid hormone 2 receptor and tuberoinfundibular peptide of 39 residues. Front Neuroendocrinol 2000;21:349-83.
9. Piserchio A, Usdin TB, Mierke DF. Structure of Tuberoinfundibular peptide of 39 residues. J Biol Chem 2000; 275:27284-90.
10. Takasu H, Gardella TJ, Luck MD, Potts JT Jr, Bringhurst FR. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: Implications for design of signal-specific PTH ligands. Biochemistry 1999;38:13453-60.
11. Juppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts JT Jr, et al. The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH (1-34). Endocrinology 1994;134:879-84.
12. Shimizu M, Potts JT Jr, Gardella TJ. Minimization of parathyroid hormone (Novel amino-terminal parathyroid hormone fragments with enhanced potent in activating the type-1 parathyroid hormone receptor). J Biol Chem 2000;275:21836-43.
13. Piserchio A, Bisello A, Rosenblatt M, Chorev M, Mierke DF. Characterization of parathyroid hormone/receptor interactions: Structure of the first extracellular loop. Biochemistry 2000;39:8153-60.
14. Pellegrini M, Bisello A, Chorev M, Mierke DF. Binding domain of human parathyroid hormone receptor: From conformation to function. Biochemistry 1998;37:12737-43.
15. Luck MD, Carter PH, Gardella TJ. The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors. Mol Endocrinol 1999;13:670-80.
16. Shimizu N, Guo J, Gardella TJ. Parathyroid hormone (PTH)-(1-14) and -(1-11) analogs conformationally constrained by α-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor. J Biol Chem 2001;276:49003-12.
17. Shimizu M, Carter PH, Khatri A, Potts JT Jr, Gardella TJ. Enhanced activity in parathyroid hormone-(1-14) and -(1-11): Novel peptides for probing ligand-receptor interactions. Endocrinology 2001;142:3068-74.
18. Horiuchi N, Holick MF, Potts JT Jr, Rosenblatt M. A parathyroid hormone inhibitor in vivo: design and biologic evaluation of a hormone analogue. Science 1983;220:1053-5.
19. 2 by substitution of PTH amino acids at positions 10 and 11. Endocrinology 1990;127:491-3.
20. Takasu H, Guo J, Bringhurst FR. Dual signaling and ligand selectivity of human PTH/PTHrp receptor. J Bone Miner Res 1999;14:11-20.
21. Davis DG, Bax A. Assignment of complex 1H NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy. J Am Chem Soc 1985;107:2820-1.
22. Jeener J, Meier BH, Bachman P, Ernst RR. Investigation of exchange processes by two-dimensional NMR spectroscopy. J Chem Phys 1979;71:4546-53.
23. 1H-NMR spectra of proteins via double quantum filtering. Biochem Biophys Res Commun 1983;117: 479-85.
24. 1H spin-spin coupling constants in proteins. Biochem Biophys Res Commun 1983;113:967-74.
25. Driscoll PC, Gronenborn AM, Beress L, Clore GM. Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-1 from the sea anemone Anemonia sulcata: A study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing. Biochemistry 1989;28:2188-98.
26. Nilges M, Clore GM, Gronenborn AM. Determination of three-dimensional structures of proteins from interproton distance data by hybrid distance geometry-dynamical simulated annealing calculations. FEBS Lett 1988;229:317-24.
27. Nilges M, Clore GM, Gronenborn AM. Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms. Circumventing problems associated with folding. FEBS Lett 1988;239:129-36.
28. Nilges M, Gronenborn AM, Brunger AT, Clore GM. Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2. Protein Eng 1988;2:27-38.
29. Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, et al. Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination. Acta Cryst 1998;D54:905-21.
30. Wuthrich K. NMR of Proteins and Nucleic Acids. New York: Wiley; 1986.