Anaesthetic neurotoxicity in rodents: Is the ketamine controversy real?

Acta Paediatrica, International Journal of Paediatrics

Volumn 96, Issue 11, 2007, Pages 1554-1556

  Bhutta, Adnan T ^a   Venkatesan, Ajay K ^b   Rovnaghi, Cynthia R ^b   Anand, K J S ^c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ALZHEIMER DISEASE; ANESTHESIA COMPLICATION; ANESTHESIA INDUCTION; APOPTOSIS; BRAIN CELL; CONTINUOUS INFUSION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG METABOLISM; DRUG OVERDOSE; EXCITOTOXICITY; INFLAMMATION; MULTIPLE DRUG DOSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REPEATED DRUG DOSE; RODENT; SHORT SURVEY;

ANESTHETICS, DISSOCIATIVE; ANIMALS; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; KETAMINE; NEUROTOXICITY SYNDROMES; RECEPTORS, N-METHYL-D-ASPARTATE; RODENTIA;

EID: 35348981248     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2007.00436.x     Document Type: Short Survey

References (27)

1. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999 283 : 70 4.
2. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003 23 : 876 82.
3. Anand KJS, Soriano SG. Anesthetic agents and the immature brain: are these toxic or therapeutic? Anesthesiology 2004 101 : 527 30.
4. Soriano SG, Loepke AW. Let's not throw the baby out with the bath water: potential neurotoxicity of anesthetic drugs in infants and children. J Neurosurg Anesthesiol 2005 17 : 207 9.
5. Hetman M, Kharebava G. Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem 2006 6 : 787 99.
6. Orser BA, Pennefather PS, MacDonald JF. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology 1997 86 : 903 17.
7. Chang Y, Chen TL, Sheu JR, Chen RM. Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol 2005 204 : 27 35.
8. Shibuta S, Varathan S, Mashimo T. Ketamine and thiopental sodium: individual and combined neuroprotective effects on cortical cultures exposed to NMDA or nitric oxide. Br J Anaesth 2006 97 : 517 24.
9. Church J, Zeman S, Lodge D. The neuroprotective action of ketamine and MK-801 after transient cerebral ischemia in rats. Anesthesiology 1988 69 : 702 9.
10. Marcoux FW, Goodrich JE, Dominick MA. Ketamine prevents ischemic neuronal injury. Brain Res 1988 452 : 329 35.
11. Proescholdt M, Heimann A, Kempski O. Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. Brain Res 2001 904 : 245 51.
12. Shapira Y, Artru AA, Lam AM. Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats. J Neurosurg Anesthesiol 1992 4 : 231 40.
13. Shapira Y, Lam AM, Eng CC, Laohaprasit V, Michel M. Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury. Stroke 1994 25 : 1637 43.
14. Spandou E, Karkavelas G, Soubasi V, AvgovstidesSavvopoulou P, Loizidis T, Guiba-Tziampiri O. Effect of ketamine on hypoxic-ischemic brain damage in newborn rats. Brain Res 1999 819 : 1 7.
15. Anand KJS, Garg S, Rovnaghi CR, Narsinghani U, Bhutta AT, Hall RW. Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res 2007 Epub ahead of print June 25.
16. Hayashi H, Dikkes P, Soriano SG. Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth 2002 12 : 770 4.
17. Scallet AC, Schmued LC, Slikker W Jr., Grunberg N, Faustino PJ, Davis H, et al. Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons. Toxicol Sci 2004 81 : 364 70.
18. Wang C, Sadovova N, Fu X, Schmued L, Scallet A, Hanig J, et al. The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture. Neuroscience 2005 132 : 967 77.
19. Wang C, Sadovova N, Hotchkiss C, Fu X, Scallet AC, Patterson TA, et al. Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture. Toxicol Sci 2006 91 : 192 201.
20. Slikker W Jr., Zou X, Hotchkiss CE, Divine RL, Sadovova N, Twaddle NC, et al. Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 2007 98 : 145 58.
21. Reisberg B, Doody R, Stoffler A, Schmitt F, Ferris S, Mobius HJ. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med 2003 348 : 1333 41.
22. Narendran R, Frankle WG, Keefe R, Gil R, Martinez D, Slifstein M, et al. Altered prefrontal dopaminergic function in chronic recreational ketamine users. Am J Psychiatry 2005 162 : 2352 9.
23. Malinovsky JM, Servin F, Cozian A, Lepage JY, Pinaud M. Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children. Br J Anaesth 1996 77 : 203 7.
24. Clancy B, Darlington RB, Finlay BL. Translating developmental time across mammalian species. Neuroscience 2001 105 : 7 17.
25. Clancy B, Finlay BL, Darlington RB, Anand KJS. Extrapolating brain development from experimental species to humans. Neurotoxicology 2007 : Epub ahead of print Feb 15.
26. Clancy B, Kersh B, Hyde J, Darlington RB, Anand KJS, Finlay BL. Web-based method for translating neurodevelopment from laboratory species to humans. Neuroinformatics 2007 5 : 79 94.
27. Anand KJS, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo WA, et al. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther 2005 27 : 814 43.