Disrupted in schizophrenia 1 and phosphodiesterase 4B: Towards an understanding of psychiatric illness

Journal of Physiology

Volumn 584, Issue 2, 2007, Pages 401-405

  Millar, Kirsty J ^a   Mackie, Shaun ^a   Clapcote, Steven J ^b   Murdoch, Hannah ^c   Pickard, Ben S ^a   Christie, Sheila ^a   Muir, Walter J ^a   Blackwood, Douglas H ^a   Roder, John C ^b   Houslay, Miles D ^c   Porteous, David J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYCLIC AMP; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; MITOCHONDRIAL PROTEIN; NEUROLEPTIC AGENT; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV BETA; ROLIPRAM; UNCLASSIFIED DRUG; PHOSPHODIESTERASE; PHOSPHODIESTERASE 4B;

BINDING AFFINITY; BINDING SITE; BRAIN DEVELOPMENT; BRAIN FUNCTION; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; DEPRESSION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEREDITY; HUMAN; MENTAL DISEASE; MISSENSE MUTATION; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RISK FACTOR; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; ARTICLE; BIPOLAR DISORDER; COMPLEX FORMATION; DISC GENE; GENE DELETION; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC ASSOCIATION; GENETIC RISK; HAPLOINSUFFICIENCY; MAJOR DEPRESSION; PDE4 GENE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ANIMALS; BINDING SITES; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DEPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDROLYSIS; MENTAL DISORDERS; MICE; MUTATION; NERVE TISSUE PROTEINS; PHENOTYPE; PROTEIN ISOFORMS; RISK FACTORS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 35348919486     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.140210     Document Type: Conference Paper

References (24)

1. Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ & Muir WJ (2001). Schizophrenia and affective disorders - Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family. Am J Hum Genet 69, 428-433.
2. Blackwood DH, Pickard BJ, Thomson PA, Evans KL, Porteous DJ & Muir WJ (2007). Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1. Neurotox Res 11, 73-83.
3. Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ & Brandon NJ (2007). Disrupted in Schizophrenia 1 interactome: Evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry 12, 74-86.
4. Cheung YF, Kan Z, Garrett-Engele P, Gall I, Murdoch H, Baillie GS, Camargo LM, Johnson JM, Houslay MD & Castle JC (2007). PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). J Pharmacol Exp Ther 322, 600-609.
5. Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, Ogawa F, Lerch JP, Trimble K, Uchiyama M, Sakuraba Y, Kaneda H, Shiroishi T, Houslay MD, Henkelman RM, Sled JG, Gondo Y, Porteous DJ & Roder JC (2007). Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 54, 387-402.
6. Clapcote SJ & Roder JC (2006). Deletion polymorphism of Disc1 is common to all 129 mouse substrains: Implications for gene-targeting studies of brain function. Genetics 173, 2407-2410.
7. Davis RL (1996). Physiology and biochemistry of Drosophila learning mutants. Physiol Rev 76, 299-317.
8. Houslay MD & Adams DR (2003). PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J 370, 1-18.
9. Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y et al. (2007). Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Mol Psychiatry (in press)
10. James R, Adams RR, Christie S, Buchanan SR, Porteous DJ & Millar JK (2004). Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci 26, 112-122.
11. Kanes SJ, Tokarczyk J, Siegel SJ, Bilker W, Abel T & Kelly MP (2007). Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience 144, 239-246.
12. Kirkpatrick B, Xu L, Cascella N, Ozeki Y, Sawa A & Roberts RC (2006). DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J Comp Neurol 497, 436-450.
13. Koike H, Arguello PA, Kvajo M, Karayiorgou M & Gogos JA (2006). Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103, 3693-3697.
14. Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, Mitkus S, Weickert CS, Matsumoto M, Sawa A, Straub RE, Vakkalanka R, Herman MM, Weinberger DR & Kleinman JE (2006). Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet 15, 1245-1258.
15. Lynch MJ, Hill EV & Houslay MD (2006). Intracellular targeting of phosphodiesterase-4 underpins compartmenta-lized cAMP signaling. Curr Topics Dev Biol 75, 225-259.
16. Mackie S, Millar JK & Porteous DJ (2007). Role of DISC1 in neural development and schizophrenia. Curr Opin Neurobiol 17, 95-102.
17. Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis MG & Sawa A (2006). Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biol Psychiatry 60, 929-935.
18. Maier W, Zobel A & Wagner M (2006). Schizophrenia and bipolar disorder: Differences and overlaps. Curr Opin Psychiatry 19, 165-170.
19. Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ & Porteous DJ (2005). DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310, 1187-1191.
20. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, Clair DM, Muir WJ, Blackwood DH & Porteous DJ (2000). Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 9, 1415-1423.
21. Murdoch H, Mackie S, Collins D, Hill E, Bolger G, Klussmann E, Porteous D, Millar K, Houslay M (2007). Isoform selective susceptibility of DISC1/ phosphodiesterase-4 (PDE4) complexes to dissociation by elevated intracellular cAMP, levels. J Neurosci (in press).
22. O'Donnell JM & Zhang HT (2004). Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4). Trends Pharmacol Sci 25, 158-163.
23. Pickard BS, Thomson PA, Christoforou A, Evans KL, Morris SW, Porteous DJ, Blackwood DH & Muir WJ (2007). The PDE4B gene confers sex-specific protection against schizophrenia. Psychiatr Genet 17, 129-133.
24. Porteous DJ, Thomson P, Brandon NJ & Millar JK (2006). The genetics and biology of DISC1 - an emerging role in psychosis and cognition. Biol Psychiatry 60, 123-131.