PET measures of pre- and post-synaptic cardiac beta adrenergic function

Nuclear Medicine and Biology

Volumn 30, Issue 8, 2003, Pages 795-803

  Link, Jeanne M ^a   Stratton, John R ^b   Levy, Wayne ^a   Poole, Jeanne E ^b   Shoner, Steven C ^a   Stuetzle, Werner ^b   Caldwell, James H ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Beta adrenergic; Cardiac; PET; Sympathetic function; 11C mHED; 11C CGP12177

Indexed keywords

3 HYDROXYEPHEDRINE C 11; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE C 11; CELL SURFACE RECEPTOR; NORADRENALIN TRANSPORTER; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; CELL SURFACE; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; FEMALE; HEART FUNCTION; HUMAN; MALE; MATHEMATICAL MODEL; MEASUREMENT; POSITRON EMISSION TOMOGRAPHY; PRESYNAPTIC NERVE; RECEPTOR DENSITY; SYMPATHETIC FUNCTION; SYNAPTIC EFFICACY;

EID: 0347224286     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2003.09.002     Document Type: Conference Paper

References (39)

1. Allman K.C., Stevens M.J., Wieland D.M., Hutchins G.D., Wolfe E.R., Greene D.A., Schwaiger M. Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography. J Am Coll Cardiol. 22:1993;1425-1432.
2. Bassingthwaighte J.B., Goresky C.A. Modeling in the analysis of solute and water exchange in the microvasculature. Renkin E.M., Michel C.C. Handbook of Physiology, The Cardiovascular System. 1984;549-626 American Physiology Society, New York.
3. Bengel F.M., Ueberfuhr P., Ziegler S.I., Nekolla S., Reichart B., Schwaiger M. Serial assessment of sympathetic reinnervation after orthotopic heart transplantation. A longitudinal study using PET and C-11 hydroxyephedrine. Circulation. 99:1999;1866-1871.
4. Bergmann S.R., Herrero P., Markham J., Weinheiner C.J., Walsh M.N. Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography. JACC. 14:1989;639-652.
5. 11C]CGP 12177) as a preferred radioligand for β-adrenergic receptors. Appl Radiat Isot. 42:1991;621-628.
6. Butterworth E.A., Link J.M., Caldwell J.H. Automated left ventricular region of interest definition on cardiac PET images reduces operator time . J Nucl Med. 40:1999;239P.
7. 11C-meta-hydroxyephedrine (MHED) validation of a blood-tissue exchange model . J Nucl Med. 39:1998;1327-1334.
8. Caldwell J.H., Link J.M., Li Z., Stratton J.R., Levy W.C., Poole J.E. Evaluation of pre- and post-synaptic sympathetic function in normals and subjects with CAD and LV dysfunction. J Nucl Med. 43:2002;141P.
9. Caldwell J.H., Stratton J.R., Link J.M., Li Z. Global and regional pre- and post-synaptic function in sudden cardiac death survivors. J Nucl Cardiol. 8:2001;S82.
10. Calkins H., Allman K., Bolling S., Kirsch M., Wieland D., Morady F., Schwaiger M. Correlation between scintigraphic evidence of regional sympathetic neuronal dysfunction and ventricular refractoriness in the human heart. Circulation. 88:1993;172-179.
11. Calkins H., Lehmann M.H., Allman K., Wieland D., Schwaiger M. Scintigraphic pattern of regional cardiac sympathetic innervation in patients with familial long QT syndrome using positron emission tomography. Circulation. 87:1993;1616-1621.
12. Delforge J., Syrota A., Lancon J.P., Nakajima K., Loc'h C., Janier M., Vallois J.M., Cayla J., Crouzel C. Cardiac beta-adrenergic receptor density measured in vivo using PET, CGP 12177, and a new graphical method. J Nucl Med. 32:1991;739-748.
13. Francis G.S. Neurohormones in congestive heart failure. Cardio Rev. 1:1993;278-289.
14. Francis G.S., Cohn J.N., Johnson G., Rector T.S., Goldman S., Simon A. Plasma norepinephrine, plasma renin activity and congestive heart failure. Circulation. 87:1993;40-48.
15. 11C]-CGP 12177 from optically active precursors. J Label Cmpd Radiopharm. XXIX:1991;681-690.
16. 11C]-S-4-(tert-butylamino-2-hydroxypropoxy)-benzimidazol-2- one in the dog . J Chromatography. 570:1991;361-370.
17. King R.B., Deussen A., Raymond G.R., Bassingthwaighte J.B. A vascular transport operator. Am J Physiol. 265:1993;H2196-2208.
18. Krohn K.A., Link J.M. Considerations in using a neutron therapy cyclotron for PET radioisotope production. Radiology. 161:1986;70.
19. Krohn K.A., Link J.M., Lewellen T.K., Risler R., Eenmaa J., Maier M. The use of 50 MeV protons to produce C-11 and O-15. J Label Cmpds Radiopharm. 23:1986;1190-1192.
20. Kroll K., Stepp D.W. Adenosine kinetics in the canine coronary circulation. Am J Physiol. 270:1996;H1469-1483.
21. Kuikka J., Levin M., Bassingthwaighte J.B. Multiple tracer dilution estimates of D- and 2-deoxy-D-glucose uptake by the heart. Am J Physiology. 250:1986;H29-42.
22. 11C-phosgene. J Nucl Med. 42:2001;20P.
23. Link JM, Krohn KA. An alternative approach to filling and emptying syringes, external pressure rather than a syringe pump or piston, Proceedings of the 8th workshop of targetry and target chemistry, St. Louis (1999).
24. 2. J Label Cmpd Radiopharm. 40:(Suppl I):1997;S306-308.
25. 2 in a single pass reaction. Nucl Med and Biol. 24:1997;93-97.
26. 11C]-meta-hydroxyephedrine and metabolites in plasma. J Chrom B. 693:1997;31-41.
27. Link J.M., Synovec R.E., Krohn K.A., Caldwell J.H. Measurement of metabolites of [C-11] meta-hydroxyephedrine [C-11]-MHED. J Nucl Med. 37:1996;205P.
28. Luthra S.K., Osman C.J., Steel M.P., Law M.P., Rhodes C.J., Vaja V., Ahier R., Brady F., Waters S.L., De Silva R., Hughes J.M.B., Camici P.G. Comparison of S-[C-11]CGP 12177 metabolism in rat, dog, and man using solid phase extraction and HPLC. J Labelled Cmpd Radiopharm. 32:1993;504-505.
29. Meredith I.T., Broughton A., Jennings G.L., Esler M.D. Evidence of selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med. 325:1991;618-624.
30. 11C CGP-12177 to assess β-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation. 87:1993;1169-1178.
31. Rosenspire K.C., Haka M.S., Van Dort M.E., Jewett D.M., Gildersleeve D.L., Schwaiger D.M., Wieland D.M. A synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine a false transmitter agent for heart neuronal imaging . J Nucl Med. 31:1990;1328-1334.
32. Schwaiger M., Kalff V., Rosenspire K., Haka M.S., Molina E., Hutchins G.D., Deeb M., Wolfe E., Wieland D.M. Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation. 82:1990;457-464.
33. Spooner P.M., Albert C., Benjamin E.J., Boineau R., Elston R.C., George A.I., Jouven X., Kuller L.H., MacCluer J.W., Marban E., Muller J.E., Schwartz P.J., Siscovick D.S., Tracy R.P., Zareba W., Zipes D.P. Sudden cardiac death, genes, and arrhythmogenesis consideration of new population and mechanistic approaches from a national Heart, Lung, and Blood Institute workshop, part I . Circulation. 103:2001;2361-2364.
34. Spooner P.M., Albert C., Benjamin E.J., Boineau R., Elston R.C., George A.L., Jouven X., Kuller L.H., MacCluer J.W., Marban E., Muller J.E., Schwartz P.J., Siscovick D.S., Tracy D.S., Zareba W., Zipes D.P. Sudden cardiac death, genes, and arrhythmogenesis consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part II . Circulation. 103:2001;2447-2452.
35. Stevens M.J., Raffel D.M., Allman K.C., Dayanikli F., Ficaro E., Sandford T., Wieland D.M., Pfeifer M.A., Schwaiger M. Cardiac sympathetic dysinnervation in diabetes implications for enhanced cardiovascular risk . Circulation. 98:1998;961-968.
36. Stevens M.J., Raffel D.M., Allman K.C., Schwaiger M., Wieland D.M. Regression and progression of cardiac sympathetic dysinnervation complicating diabetes an assessment by C-11 hydroxyephedrine and positron emission tomography . Metabolism. 48:1999;92-101.
37. Stevenson W.G., Epstein L.M. Predicting sudden death risk for heart failure patients in the implantable cardioverter-defibrillator age. Circulation. 107:2003;514-516.
38. 11C-meta-hydroxyephedrine. J Nucl Med. 41:2000;48P.
39. Ungerer M., Hartmann F., Karoglan M., Chlistalla A., Ziegler S., Richardt G., Overbeck M., Meisner H., Schomig A., Schwaiger M. Regional in vivo and in vitro characterization of autonomic innervation in cardiomyopathic human heart. Circulation. 97:1998;174-180.