Uptake-1 carrier downregulates in parallel with the β-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: Implications for cardiac neuroimaging in human cardiomyopathies

Journal of Nuclear Medicine

Volumn 44, Issue 9, 2003, Pages 1459-1466

  Mardon, Karine ^a   Montagne, Olivier ^a,b   Elbaz, Nathalie ^b   Malek, Zoulikha ^c   Syrota, André ^a   Dubois Randé, Jean Luc ^b,c   Meignan, Michel ^c   Merlet, Pascal ^b,c  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b Université de Médecine   (France)

^c HENRI MONDOR HOSPITAL   (France)

Author keywords

adrenergic receptor; Hydroxyephedrine; MIBG; Norepinephrine; PET; Radiolabeled norepinephrine analogs; Single photon imaging; Uptake 1

Indexed keywords

(3 IODOBENZYL)GUANIDINE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; IODINE 123; MAZINDOL; NORADRENALIN; SODIUM CHLORIDE; TRITIUM; ADRENERGIC RECEPTOR AFFECTING AGENT; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CARDIOMYOPATHY; CIRCULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENSITY; DOWN REGULATION; ENZYME ACTIVITY; EXCISION; EXPOSURE; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART STIMULATION; HEART SURGERY; IMPLANTATION; IN VITRO STUDY; INFUSION; ISOTOPE LABELING; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RADIOCARDIOGRAPHY; RAT; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; HEART VENTRICLE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; REFERENCE VALUE; SCINTISCANNING; STATISTICS; WISTAR RAT;

3-IODOBENZYLGUANIDINE; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; CARDIOMYOPATHIES; HEART VENTRICLES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; NOREPINEPHRINE; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; REFERENCE VALUES; STATISTICS;

EID: 0142243370     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Carrio I. Cardiac neurotransmission imaging. J Nucl Med. 2001;42:1062-1076
2. Glowniak JV, Turner FE, Gray LL, Palac RT, Lagunas-Solar MC, Woodward WR. Iodine-123 metaiodobenzyiguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants. J Nucl Med 1989;30:1182-1191.
3. Dae MW, De Marco T, Botvinick EH, et al Scintigraphic assessment of MIBG uptake is globally denervated human and canine hearts: implications for clinical studies. J Nucl Med. 1992;33:1444-1450.
4. Merlet P, Benvenuti C, Moyse D, et al. Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy. J Nucl Med. 1999;40:917-923.
5. Stanton MS, Tuli MM, Radtke NL, et al. Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123-metaiodobenzylguanidine. J Am Coll Cardiol 1989;14:1519-1526.
6. 123I-meta-iodobenzylguanidme (MIBG) uptake in hypertrophic cardiomyopalhy. Am Heart J. 1990;119:1329-1337.
7. Scherrer-Crosbie M, Mardon K, Cayla J, Syrota A, Merlet P. Alterations of myocardial sympathetic innervation in response to hypoxia. J Natl Med. 1997;38:954-957.
8. Ungerer M, Hartmann F, Karoglan M, et al. Regional in vivo and in vitro characterization of autonomic innervation in cardiomyopathic human heart Circulation. 1998;97:174-180
9. Schafers M, Dutka D, Rhodes CG, et al. Myocardial presynaptic and postsynaptic autonomie dysfunction in hypertrophic cardiomyopathy. Circ Res, 1998;82:57-62.
10. Yoshioka K, Gao DW, Chin M, et al. Heterogeneous sympathetic innervation influences local myocardial repolanzation in normally perfused rabbit hearts Circulation 2000;101:1060-1066.
11. Schwaiger M, Hutchins GD, Kalff V, et al. Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography. J Clin Invest. 1991;87:1681-1690.
12. Minardo JD, Tuh MM, Mock BH, et al. Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application. Circulation. 1988;78: 1008-1019.
13. Liang CS, Fan TH, Sullebarger JT, Sakamoto S. Decreased adrenergic neuronal uptake activity in experimental right heart failure: a chamber-specific contributor to beta-adrenoceptor downregulation J Clin Invest. 1989;84:1267-1275.
14. Himura Y, Feiten SY, Kashiki M, Lewandowski TJ, Delehanty JM, Liang CS. Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation. 1993;88:1299-1309.
15. Qin F, Raju S, Vulapalli RS, Stevens SY, Liang CS. Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF Am J Physiol Heart Circ Physiol. 2002;282:H363-H371.
16. Iversen LL. The uptake of catecholamines at high perfusion concentrations in the rat isolated heart: a novel catecholamine uptake process. Br J Pharmacol. 1965;25:18-33.
17. Nakajo M, Shimabukuro K, Yoshimura H. Iodine-131 metaiodobenzylguanidine intra- and extravesicular accumulation in the rat heart. J Nucl Med. 1986;27: 84-89.
18. Hartree EF. Modification of the Lowry method that gives a linear photometric response Anal Biochem. 1972;48:422-427.
19. 3H]Mazindol binding associated with neuronal dopamine and NE uptake sites. Mol Pharmacol. 1984;26:35-44.
20. Salomon Y. Adenylate cyclase assay. Adv Cyclic Nucleotide Res. 1979;10:35-55.
21. Russ H, Gliese M, Sonna J, Schomig E The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4- phenylpyridinium (MPP+) Naunyn Schmiedebergs Arch Pharmacol 1992;346:158-165.
22. Levy MN, Blattberg B. The influence of cocaine and desipramine on the cardiac responses to exogenous and endogenous norepinephnne. Eur J Pharmacol. 1978;48:37-49.
23. Masuda Y, Levy MN. The effects of neuronal uptake blockade on the cardiac responses to sympathetic nerve stimulation and norepinephnne infusion in anesthetized dogs. J Auton Nerv Syst. 1984;10:1-17.
24. Wieland DM, Brown LE, Rogers WL, et al Myocardial imaging with a radioiodinated norepincphrine storage analog. J Nucl Med. 1981;22:22-31.
25. Tobes MC, Jaques S Jr, Wieland DM, Sisson JC Effect of uptake-one inhibitors on the uptake of norepinephnne and metaiodobenzylguanidine. J Nucl Med 1985;26:897-907.
26. Glowniak JV, Kilty JE, Amara SG, Hoffman BJ, Turner FE. Evaluation of metaiodobenzylguanidine uptake by the norepinephnne, dopamine and serotonin transporters. J Nucl Med. 1993;34:1140-1146.
27. 76Br]MBBG). Nucl Med Biol. 1994;21:49-55.
28. Eisenhofer G, Friberg P, Rundqvist B, et al. Cardiac sympathetic nerve function in congestive heart failure. Circulation 1996;93:1667-1676.
29. Bohm M, La Rosce K, Schwinger RH, Erdmann E Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol. 1995;25:146-153.
30. Bristow MR, Minobe W, Rasmussen R, et al. Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest. 1992;89:803-815.
31. Merlet P, Dubois-Rande JL, Adnot S, et al. Myocardial beta-adrenergic desensitization and neuronal norepmephrine uptake function in idiopathic dilated cardiomyopaihy. J Cardiovasc Pharmacol. 1992;19:10-16.
32. Beau SL, Saffitz JE. Transmural heterogeneity of norepinephrine uptake in failing human hearts. J Am Coll Cardiol 1994;23:579-585.
33. Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure: U.S. Carvedilol Heart Failure Study Group. JV Engl J Med. 1996;334:1349-1355.
34. Merit-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet. 1999;353:2001-2007
35. Cibis-II Investigators and Committee. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet. 1999;353:9-13
36. de Milliano PAR, de Oroot AC, Tijssen JOP, van Eck-Smit BLF, van Zwieten PA, Lie KI. Beneficial effects of metoprolol on myocardial sympathetic function: evidence from a randomized, placebo-controlled study in patients with congestive heart failure Am Heart J 2002;144:E3.
37. Wichter T, Schafers M, Rhodes CG, et al. Abnormalities of cardiac sympathetic innervation in arrhythmogenic right ventricular cardiomyopathy: quantitative assessment of presynaptic norepinephrine reuptake and postsynaptic beta-adrenergic receptor density with positron emission tomography. Circulation. 2000; 101:1552-1558.
38. Zerkowski HR, Khamssi M, Brodde OE. Development of beta-adrenoceptor number and subtype distribution in the transplanted human heart. Eur Heart J. 1991;12(suppl F):124-126.
39. Sato N, Vatner SF,. Shen YT, et al. Effects of cardiac denervation on development of heart failure and catecholamine desensitization. Circulation. 1997;95:2130-2140.
40. Giowniak JV, Wilson RA, Joyce ME, Turner FE. Evaluation of metaiodobenzylguanidine heart and lung extraction fraction by first-pass analysis in pigs. J Nucl Med. 1992;33:716-723