Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: A mechanism for ischemia selectivity

Basic Research in Cardiology

Volumn 102, Issue 6, 2007, Pages 553-564

  Pignier, Christophe ^a   Revenaz, C ^a   Rauly Lestienne, I ^a   Cussac, D ^a   Delhon, A ^a   Gardette, J ^b   Grand, B ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b Centre d'Immunologie Pierre Fabre   (France)

Author keywords

Fatty acids; Ischemia; Long QT syndrome; Na+ channels; Persistent sodium current

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; POLYUNSATURATED FATTY ACID; SODIUM CHANNEL; SODIUM CHANNEL SCN5A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSFECTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; HUMAN CELL; IC 50; MALE; METABOLIC REGULATION; NONHUMAN; PATCH CLAMP; RAT; SODIUM CURRENT; SODIUM TRANSPORT; STEADY STATE; WILD TYPE;

ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIOTONIC AGENTS; CELL LINE; DISEASE MODELS, ANIMAL; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HUMANS; MALE; MUSCLE PROTEINS; MYOCARDIAL ISCHEMIA; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TRANSFECTION; VERATRIDINE;

EID: 35348865551     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-007-0676-x     Document Type: Article

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