Effects of a common human gene variant of extracellular superoxide dismutase on endothelial function after endotoxin in mice

Journal of Physiology

Volumn 584, Issue 2, 2007, Pages 583-590

  Lund, Donald D ^a,b   Chu, Yi ^a   Brooks, Robert M ^a   Faraci, Frank M ^a   Heistad, Donald D ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOVIRUS VECTOR; BETA GALACTOSIDASE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HEPARIN BINDING PROTEIN; HYDROETHIDINE; LUCIGENIN; NITROPRUSSIDE SODIUM; SUPEROXIDE DISMUTASE; ENDOTOXIN; EXTRACELLULAR SUPEROXIDE DISMUTASE; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ENDOTHELIAL DYSFUNCTION; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME BINDING; GENE EXPRESSION; GENE TRANSFER; GENETIC VARIABILITY; IN VITRO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; VASOCONSTRICTION; VASODILATATION; ADULT; ANTIOXIDANT ACTIVITY; IN VIVO STUDY;

ACETYLCHOLINE; ADENOVIRIDAE; ANIMALS; AORTA; BETA-GALACTOSIDASE; DINOPROST; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GENES, REPORTER; GENETIC VECTORS; HUMANS; INFLAMMATION; LAC OPERON; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITROPRUSSIDE; POLYMORPHISM, GENETIC; SUPEROXIDE DISMUTASE; SUPEROXIDES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 35348852003     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.140830     Document Type: Article

References (33)

1. Adachi T, Yamada H, Yamada Y, Morihara N, Yamazaki N, Murakami T, Futenma A, Kato K & Hirano K (1996). Substitution of glycine for arginine-213 in extracellularsuperoxide dismutase impairs affinity for heparin and endothelial cell surface. Biochem J 313, 235-239.
2. Biguad M, Julou-Schaeffer G, Parratt JR & Stoclet JC (1990). Endotoxin-induced impairment of vascular smooth muscle contractions elicited by different mechanisms. Eur J Pharmacol 190, 185-192.
3. Boyle WA 3rd, Parvathaneni LS, Bourlier V, Sauter C, Laubach VE & Cobb JP (2000). iNOS gene expression modulates microvascular responsiveness in endotoxin-challenged mice. Circ Res 87, E18-E24.
4. Brovkovych V, Patton S, Brovkovych S, Kiechle F, Huk I & Malinski T (1997). In situ measurement of nitric oxide, superoxide and peroxynitrite during endotoxemia. J Physiol Pharmacol 48, 633-644.
5. Chu Y, Alwahdani A, Iida S, Lund DD, Faraci FM & Heistad DD (2005). Effects of gene variant of extracellular superoxide dismutase in spontaneously hypertensive rats. Circulation 112, 1047-1053.
6. Chu Y & Heistad DD (2002). Gene transfer to blood vessels using adenoviral vectors. Methods Enzymol 346, 263-276.
7. Chu Y, Iida S, Lund DD, Weiss RM, DiBona GF, Watanabe Y, Faraci FM & Heistad DD (2003). Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: Role of heparin-binding domain. Circ Res 92, 461-468.
8. Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL & Szabo C (1998). Effect of 1-buthionine-(S,R) -sulphoximine, an inhibitor of γ-glutamylcysteine synthase on peroxynitrite- and endotoxic shock-induced vascular failure. Br J Pharmacol 123, 525-537.
9. Didion SP, Kinzenbaw DA, Fegan PE, Didion LA & Faraci FM (2004). Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction. Stroke 36, 1963-1967.
10. Folz RJ, Peno-Green L & Crapo JD (1994). Identification of a homozygous missense mutation (Arg to Gly) in the critical binding region of human EC-SOD gene (SOD3) and its association with dramatically increased serum enzyme levels. Hum Mol Genet 3, 2251-2254.
11. Fukai T, Folz RJ, Landmesser U & Harrison DG (2002). Extracellular superoxide dismutase and cardiovascular disease. Cardiovasc Res 55, 239-249.
12. Gunnett CA, Berg DJ & Faraci FM & Feuerstein G (1999). Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice. Stroke 30, 2191-2196.
13. Gunnett CA, Chu Y, Heistad DD, Loihl A & Faraci FM (1998). Vascular effects of LPS in mice deficient in expression of the gene for inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol 275, H416-H421.
14. Gunnett CA, Heistad DD, Berg DJ & Faraci FM (2000). IL-10 deficiency increases superoxide and endotheli1al dysfunction during inflammation. Am J Physiol Heart Circ Physiol 279, H1555-H1562.
15. Gunnett CA, Lund DD, Faraci FM & Heistad DD (2005). Vascular interleukin-10 protects against LPS-induced vasomotor dysfunction. Am J Physiol Heart Circ Physiol 289, H624-H630.
16. Iida S, Chu Y, Weiss RM, Kang YM, Faraci FM & Heistad DD (2006). Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Am J Physiol Heart Circ Physiol 291, H914-H920.
17. 2in superoxide-dismutase-induced enhancement of endothelium-dependent relaxation in rabbit mesenteric resistance artery. Br J Pharmacol 139, 444-456.
18. Janiszewski M, Souza HP, Liu X, Pedro MA, Sweier JL & Laurindo FR (2002). Overestimation of NADP-driven vascular oxidase activity due to lucigenin artifacts. Free Radic Biol Med 31, 446-453.
19. Javesghani D, Hussain SN, Scheidel J, Quinn MT & Magder SA (2003). Superoxide production in the vasculature of lipopolysaccharide-treated rats and pigs. Shock 19, 486-493.
20. Jung O, Markland SL, Geiger H, Pedrazzini T, Busse R & Brandes RP (2003). Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability. In vivo and ex vivo evidence from ecSOD-deficient mice. Circ Res 93, 622-629.
21. Juul K, Tybjaerg-Hansen A, Marklund S, Heegaard NH, Steffensen R, Sillesen H, Jensen G & Nordestgaard BG (2004). Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. Circulation 109, 59-65.
22. Lund DD, Gunnett CA, Chu Y, Brooks RM, Faraci FM & Heistad DD (2004). Gene transfer of extracellular superoxide dismutase improves relaxation of aorta after treatment with endotoxin. Am J Physiol Heart Circ Physiol 287, H805-H811.
23. Marklund S (1982). Human copper-containing superoxide dismutase of high molecular weight. Proc Natl Acad Sci U S A 79, 7634-7638.
24. Marklund SL, Holme E & Hellner L (1982). Superoxide dismutase in extracellular fluids. Clin Chim Acta 126, 41-51.
25. Marklund SL, Nilsson P, Israelsson K, Schampi I, Peltonen M & Asplund K (1997). Two variants of extracellular-superoxide dismutase: relationship to cardiovascular risk factors in an unselected middle-aged population. J Intern Med 242, 5-14.
26. Miller WH, Brosnan MJ, Graham D, Nicol CG, Morecroft I, Channon KM, Danilov SM, Reynolds PN, Baker AH & Dominiczak AF (2005). Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Mol Ther 12, 321-327.
27. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD & Davidson BL (1998). Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 82, 1298-1305.
28. Nakane H, Miller FJ Jr, Faraci FM, Toyoda K & Heistad DD (2000). Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction. Hypertension 35, 595-601.
29. Nicol CG, Graham D, Miller WH, White SJ, Smith TA, Nicklin SA, Stevenson SC & Baker AH (2004). Effects of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats. Mol Ther 10, 344-354.
30. Rey FE, Li XC, Carretero OA, Garvin JL & Pagano PJ (2002). Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: Role of gp91 (phox). Circulation 106, 2497-2502.
31. Ulker S, Cinar MG, Can C, Evinc A & Kosay S (2001). Endotoxin-induced vascular hyporesponsiveness in rat aorta: In vitro effect of aminoguanidine. Pharmacol Res 44, 22-27.
32. Watanabe Y, Chu Y, Andresen JJ, Nakane H, Faraci FM & Heistad DD (2003). Gene transfer of extracellular superoxide dismutase reduces cerebral vasospasm after subarachnoid hemorrhage. Stroke 34, 434-440.
33. Yamada H, Yamada Y, Adachi T, Fukatsu A, Sakuma M, Futenma A & Kakumu S (2000). Protective role of extracellular superoxide dismutase in hemodialysis patients. Nephron 84, 218-223.