메뉴 건너뛰기




Volumn 17, Issue 1, 2007, Pages 153-159

Cyclophosphamide augments the anti-tumor efficacy of uracil and tegafur by inhibiting dihydropyrimidine dehydrogenase

Author keywords

Breast cancer; Cyclophosphamide; Dihydropyrimidine dehydrogenase; Thymidylate synthase; Uracil and tegafur (UFT)

Indexed keywords

1 UFT PROTOCOL; 1-UFT PROTOCOL; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DIHYDROPYRIMIDINE DEHYDROGENASE; TEGAFUR; THYMIDYLATE SYNTHASE; URACIL;

EID: 35348838676     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.1.153     Document Type: Article
Times cited : (10)

References (45)
  • 1
    • 0023726563 scopus 로고
    • Report on nationwide pooled data and cohort investigation in UFT phase II study
    • Ohta K, Taguchi T and Kimura K: Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother Pharmacol 22: 323-328, 1988.
    • (1988) Cancer Chemother Pharmacol , vol.22 , pp. 323-328
    • Ohta, K.1    Taguchi, T.2    Kimura, K.3
  • 2
    • 0031727480 scopus 로고    scopus 로고
    • Uracil-ftorafur: An oral fluoropyrimidine active in colorectal cancer
    • Sulkes A, Benner S and Canetta R: Uracil-tegafur: An oral fluoropyrimidine active in colorectal cancer. J Clin Oncol 16: 3461-3475, 1998. (Pubitemid 28481645)
    • (1998) Journal of Clinical Oncology , vol.16 , Issue.10 , pp. 3461-3475
    • Sulkes, A.1    Benner, S.E.2    Canetta, R.M.3
  • 3
    • 0033790705 scopus 로고    scopus 로고
    • Oral fluoropyrimidines in colorectal cancer
    • Van Cutsem E and Peeters M: Oral fluoropyrimidines in colorectal cancer. Semin Oncol 27 (suppl 10): 91-95, 2000.
    • (2000) Semin Oncol , vol.27 , Issue.SUPPL. 10 , pp. 91-95
    • Van Cutsem, E.1    Peeters, M.2
  • 5
    • 0034305703 scopus 로고    scopus 로고
    • UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer
    • Gregory RK, Johnston SR, Smith IE and Miles D: UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer. Oncology 14: 47-49, 2000.
    • (2000) Oncology , vol.14 , pp. 47-49
    • Gregory, R.K.1    Johnston, S.R.2    Smith, I.E.3    Miles, D.4
  • 7
    • 68549134185 scopus 로고    scopus 로고
    • Chemotherapy of pancreatic cancer - Adjuvant chemotherapy
    • Nio Y: Chemotherapy of pancreatic cancer - Adjuvant chemotherapy. Consensus Cancer Ther (in Japanese) 2: 28-31, 2003.
    • (2003) Consensus Cancer Ther (In Japanese) , vol.2 , pp. 28-31
    • Nio, Y.1
  • 8
    • 0033208949 scopus 로고    scopus 로고
    • A case of recurrent ampullary carcinoma of the papilla of Vater in which a complete response was induced by combination therapy using radiotherapy and oral chemotherapy employing UFT and cyclophosphamide
    • Iguchi C, Nio Y, Sato Y, et al: A case of recurrent ampullary carcinoma of the papilla of Vater in which a complete response was induced by combination therapy using radiotherapy and oral chemotherapy employing UFT and cyclophosphamide. Gan To Kagaku Ryoho (in Japanese) 26: 1641-1645, 1999.
    • (1999) Gan to Kagaku Ryoho (In Japanese) , vol.26 , pp. 1641-1645
    • Iguchi, C.1    Nio, Y.2    Sato, Y.3
  • 9
    • 0033632054 scopus 로고    scopus 로고
    • A case of recurrent pancreatic cancer brought into a complete response by a multimodal treatment with intraarterial chemotherapy and radiotherapy
    • Minari Y, Nio Y, Endo S, et al: A case of recurrent pancreatic cancer brought into a complete response by a multimodal treatment with intraarterial chemotherapy and radiotherapy. Gan To Kagaku Ryoho (in Japanese) 27: 121-125, 2000.
    • (2000) Gan to Kagaku Ryoho (In Japanese) , vol.27 , pp. 121-125
    • Minari, Y.1    Nio, Y.2    Endo, S.3
  • 10
    • 0032806661 scopus 로고    scopus 로고
    • Antitumor efficacy of combination chemotherapy with UFT and cyclophosphamide against human breast cancer xenografts in nude mice
    • Haga S, Shimizu T, Imamura H, et al: Antitumor efficacy of combination chemotherapy with UFT and cyclophosphamide against human breast cancer xenografts in nude mice. Anticancer Res 19: 1791-1796, 1999. (Pubitemid 29392739)
    • (1999) Anticancer Research , vol.19 , Issue.3 A , pp. 1791-1796
    • Haga, S.1    Shimizu, T.2    Imamura, H.3    Watanabe, O.4    Kinoshita, J.5    Fukushima, M.6    Kajiwara, T.7
  • 11
    • 0032856558 scopus 로고    scopus 로고
    • Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models
    • DOI 10.1002/(SICI)1097-0215(19990924)83:1<127::AID
    • Endo M, Sinbori N, Sawada N, et al: Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5- fluorouridine by cyclophosphamide in mammary tumor models. Int J Cancer 83: 127-134, 1999. (Pubitemid 29409488)
    • (1999) International Journal of Cancer , vol.83 , Issue.1 , pp. 127-134
    • Endo, M.1    Shinbori, N.2    Fukase, Y.3    Sawada, N.4    Ishikawa, T.5    Ishitsuka, H.6    Tanaka, Y.7
  • 12
    • 0032868050 scopus 로고    scopus 로고
    • Thymidylate synthase: A target for combination therapy and determinant of chemotherapeutic response in colorectal cancer
    • DOI 10.1159/000012030
    • Van Triest B and Peters GJ: Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer. Oncology 57: 179-194, 1999. (Pubitemid 29481691)
    • (1999) Oncology , vol.57 , Issue.3 , pp. 179-194
    • Van Triest, B.1    Peters, G.J.2
  • 15
    • 33744726186 scopus 로고    scopus 로고
    • International Union Against Cancer 6th edition. John Wiley & Sons, Inc.
    • International Union Against Cancer. TNM classification of malignant tumours. 6th edition. John Wiley & Sons, Inc., 2002.
    • (2002) TNM Classification of Malignant Tumours
  • 17
    • 0038417130 scopus 로고    scopus 로고
    • Radiological measurement of breast cancer metastases to lung and liver: Comparison between WHO (bidimensional) and RECIST (unidimensional) guidelines
    • DOI 10.1097/00004728-200305000-00014
    • Prasad SR, Saini S, Sumner JE, et al: Radiological measurement of breast cancer metastases to lung and liver: comparison between WHO (bidimensional) and RECIST (unidimensional) guidelines. J Comput Assist Tomogr 27: 380-384, 2003. (Pubitemid 36793188)
    • (2003) Journal of Computer Assisted Tomography , vol.27 , Issue.3 , pp. 380-384
    • Prasad, S.R.1    Saini, S.2    Sumner, J.E.3    Hahn, P.F.4    Sahani, D.5    Boland, G.W.6
  • 18
    • 0035221334 scopus 로고    scopus 로고
    • Histopathological criteria for assessment of therapeutic response in breast cancer
    • Commitee for Production of Histopathological Criteria, Japanese Breast Cancer Society
    • Kurosumi M, Akiyama F, Iwase T, et al: Commitee for Production of Histopathological Criteria, Japanese Breast Cancer Society. Histopathological criteria for assessment of therapeutic response in breast cancer. Breast Cancer 8: 1-2, 2001.
    • (2001) Breast Cancer , vol.8 , pp. 1-2
    • Kurosumi, M.1    Akiyama, F.2    Iwase, T.3
  • 19
    • 0021219342 scopus 로고
    • Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil
    • Spears SP, Gustavsson BG, Mitchell MS, et al: Thymidylate synthase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil. Cancer Res 44: 4144-4150, 1984. (Pubitemid 14041649)
    • (1984) Cancer Research , vol.44 , Issue.9 , pp. 4144-4150
    • Spears, C.P.1    Gustavsson, B.G.2    Mitchell, M.S.3
  • 20
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib FNM, El-Kouni MH and Cha S: Enzyme of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45: 5405-5412, 1985. (Pubitemid 16200794)
    • (1985) Cancer Research , vol.45 , Issue.11 I , pp. 5405-5412
    • Naguib, F.N.M.1    El, K.M.H.2    Cha, S.3
  • 21
    • 0030853620 scopus 로고    scopus 로고
    • Enhancing 5-fluorouracil cytotoxicity by inhibiting dihydropyrimidine dehydrogenase activity with uracil in human tumor cells
    • Takechi T, Uchida J, Fujioka A and Fukushima M: Enhancing 5-fluorouracil cytotoxicity by inhibiting dihydropyrimidine dehydrogenase activity with uracil in human tumor cells. Int J Oncol 11: 1041-1044, 1997. (Pubitemid 27439412)
    • (1997) International Journal of Oncology , vol.11 , Issue.5 , pp. 1041-1044
    • Takechi, T.1    Uchida, J.2    Fujioka, A.3    Fukushima, M.4
  • 22
    • 0031899554 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy of gastric cancer with oral UFT (a mixture of uracil and fturafur) during the waiting period for surgery
    • Nio Y, Sato Y, Nagami H, et al: Neoadjuvant chemotherapy of gastric cancer with oral UFT (a mixture of uracil and futrafur) during the waiting period for surgery. Anticancer Res 18: 523-530, 1998. (Pubitemid 28174867)
    • (1998) Anticancer Research , vol.18 , Issue.1 B , pp. 523-530
    • Nio, Y.1    Sato, Y.2    Nagami, H.3    Teramoto, M.4    Inoue, Y.5    Yano, S.6    Sumi, S.7    Tamura, K.8    Fukumoto, M.9
  • 23
    • 0034223246 scopus 로고    scopus 로고
    • Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy
    • Huang CL, Yokomise H, Kobayashi S, et al: Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy. Int J Oncol 17: 47-54, 2000.
    • (2000) Int J Oncol , vol.17 , pp. 47-54
    • Huang, C.L.1    Yokomise, H.2    Kobayashi, S.3
  • 25
    • 0037312517 scopus 로고    scopus 로고
    • Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    • Ichikawa W, Uetake H, Shirota Y, et al: Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expression in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res 9: 786-791, 2003. (Pubitemid 36182616)
    • (2003) Clinical Cancer Research , vol.9 , Issue.2 , pp. 786-791
    • Ichikawa, W.1    Uetake, H.2    Shirota, Y.3    Yamada, H.4    Nishi, N.5    Nihei, Z.6    Sugihara, K.7    Hirayama, R.8
  • 26
    • 21044458415 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test
    • DOI 10.1016/j.canlet.2004.09.020, PII S0304383504007281
    • Kakimoto M, Uetake H, Osanai T, et al: Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test. Cancer Lett 223: 103-111, 2005. (Pubitemid 40693714)
    • (2005) Cancer Letters , vol.223 , Issue.1 , pp. 103-111
    • Kakimoto, M.1    Uetake, H.2    Osanai, T.3    Shirota, Y.4    Takagi, Y.5    Takeshita, E.6    Toriya, Y.7    Danenberg, K.8    Danenberg, P.V.9    Sugihara, K.10
  • 28
    • 0033995850 scopus 로고    scopus 로고
    • Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method
    • Takenoue T, Nagawa H, Matsuda K, et al: Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method. Ann Surg Oncol 7: 193-198, 2000. (Pubitemid 30215157)
    • (2000) Annals of Surgical Oncology , vol.7 , Issue.3 , pp. 193-198
    • Takenoue, T.1    Nagawa, H.2    Matsuda, K.3    Fujii, S.4    Nita, M.E.5    Hatano, K.6    Kitayama, J.7    Tsuruo, T.8    Muto, T.9
  • 29
    • 0033824440 scopus 로고    scopus 로고
    • Thymidylate synthase expression in epithelial ovarian cancer: Relationship with thymidine phosphorylase expression and prognosis
    • Fujiwaki R, Hata K, Nakayama K, et al: Thymidylate synthase expression in epithelial ovarian cancer: relationship with thymidine phosphorylase expression and prognosis. Oncology 59: 152-157, 2000.
    • (2000) Oncology , vol.59 , pp. 152-157
    • Fujiwaki, R.1    Hata, K.2    Nakayama, K.3
  • 31
    • 0032189399 scopus 로고    scopus 로고
    • Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: The clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness
    • DOI 10.1002/(SICI)1097-0142(19981001)83:7<1300::AI
    • Kuniyasu T, Nakamura T, Tabuchi Y and Kuroda Y: Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: the clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness. Cancer 83: 1300-1306, 1998. (Pubitemid 28460079)
    • (1998) Cancer , vol.83 , Issue.7 , pp. 1300-1306
    • Kuniyasu, T.1    Nakamura, T.2    Tabuchi, Y.3    Kuroda, Y.4
  • 32
    • 0032950876 scopus 로고    scopus 로고
    • Immunohistochemical detection of thymidylate synthase in advanced gastric cancer: A prognostic indicator in patients undergoing gastrectomy followed by adjuvant chemotherapy with 5-fluoropyrimidines
    • Suda Y, Kuwashima Y, Tanaka Y, et al: Immunohistochemical detection of thymidylate synthase in advanced gastric cancer: a prognostic indicator in patients undergoing gastrectomy followed by adjuvant chemotherapy with 5-fluoropyrimidines. Anticancer Res 19: 805-810, 1999. (Pubitemid 29168335)
    • (1999) Anticancer Research , vol.19 , Issue.1 B , pp. 805-810
    • Suda, Y.1    Kuwashima, Y.2    Tanaka, Y.3    Uchida, K.4    Akazawa, S.5
  • 34
    • 0008529185 scopus 로고    scopus 로고
    • The correlation between the intratumoral thymidylate synthase levels and clinicopathological factors in colorectal cancer patients
    • Umehara A, Yoshimatsu K, Endo S, et al: The correlation between the intratumoral thymidylate synthase levels and clinicopathological factors in colorectal cancer patients. J Tokyo Wom Med Uni 70: 621-629, 2000.
    • (2000) J Tokyo Wom Med Uni , vol.70 , pp. 621-629
    • Umehara, A.1    Yoshimatsu, K.2    Endo, S.3
  • 35
    • 0035866373 scopus 로고    scopus 로고
    • Thymidine kinase and thymidylate synthase in advanced breast cancer: Response to tamoxifen and chemotherapy
    • Foekens JA, Romain S, Look MP, et al: Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy. Cancer Res 61: 1421-1425, 2001. (Pubitemid 34292567)
    • (2001) Cancer Research , vol.61 , Issue.4 , pp. 1421-1425
    • Foekens, J.A.1    Romain, S.2    Look, M.P.3    Martin, P.-M.4    Klijn, J.G.M.5
  • 37
    • 0029088368 scopus 로고
    • Clinicopathological stages and piromidine nucleotide synthesis in human mammary carcinomas
    • Ebuchi M, Sakamoto S, Kudo H, et al: Clinicopathological stages and piromidine nucleotide synthesis in human mammary carcinomas. Anticancer Res 15: 1481-1484, 1995.
    • (1995) Anticancer Res , vol.15 , pp. 1481-1484
    • Ebuchi, M.1    Sakamoto, S.2    Kudo, H.3
  • 39
    • 0029047241 scopus 로고
    • Differences in thymidylate synthetase acitivity in involved nodes compared with primary tumor in breast cancer patients
    • Komaki K, Kamamura Y, Ohmine Y, et al: Differences in thymidylate synthetase acitivity in involved nodes compared with primary tumor in breast cancer patients. Breast Cancer Res Treat 35: 157-162, 1995.
    • (1995) Breast Cancer Res Treat , vol.35 , pp. 157-162
    • Komaki, K.1    Kamamura, Y.2    Ohmine, Y.3
  • 42
    • 0028019880 scopus 로고
    • Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: Implications for treatment with fluorouracil
    • Peters GJ, van der Wilt CL, van Groeningen CJ, et al: Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. J Clin Oncol 12: 2035-2042, 1994. (Pubitemid 24356018)
    • (1994) Journal of Clinical Oncology , vol.12 , Issue.10 , pp. 2035-2042
    • Peters, G.J.1    Van Der, W.C.L.2    Van Groeningen, C.J.3    Smid, K.4    Meijer, S.5    Pinedo, H.M.6
  • 43
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, et al: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55: 1407-1412, 1995.
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3
  • 45
    • 0034486207 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil
    • Aschele C, Debernardis D, Tunesi G, et al: Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil. Clin Cancer Res 6: 4797-4802, 2000. (Pubitemid 32110422)
    • (2000) Clinical Cancer Research , vol.6 , Issue.12 , pp. 4797-4802
    • Aschele, C.1    Debernardis, D.2    Tunesi, G.3    Maley, F.4    Sobrero, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.