Characterization of two novel LPS-binding sites in leukocyte integrin βA domain

FASEB Journal

Volumn 21, Issue 12, 2007, Pages 3231-3239

  Wong, Kwong Fai ^a   Luk, John M ^a,c   Cheng, R Holland ^b   Klickstein, Lloyd B ^c   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Endotoxin neutralizing peptide; Lipopolysaccharide; NF B; Prophylaxis; Sepsis; TNF

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA INTEGRIN; CD11B ANTIGEN; CD14 ANTIGEN; CD18 ANTIGEN; ENDOTOXIN; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEPTIDE; TOLL LIKE RECEPTOR 4; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL ACTIVATION; CONTROLLED STUDY; ENDOTOXEMIA; EPITOPE MAPPING; GRAM NEGATIVE INFECTION; INHIBITION KINETICS; LEUKEMIA CELL LINE; LEUKOCYTE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD18; BINDING SITES; HUMANS; JURKAT CELLS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PEPTIDES; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 35248867073     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7579com     Document Type: Article

References (39)

1. Osborn, M. J., Rosen, S. M., Rothfield, L., Zeleznick, L. D., and Horecker, B. L. (1964) Lipopolysaccharide of the Gram-negative cell wall. Science 145, 783-789
2. Rice, T. W., and Bernard, G. R. (2005) Therapeutic intervention and targets for sepsis. Annu. Rev. Med. 56, 225-248
3. Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., and Mathison, J. C. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433
4. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088
5. Hailman, E., Lichenstein, H. S., Wurfel, M. M., Miller, D. S., Johnson, D. A., Kelley, M., Busse, L. A., Zukowski, M. M., and Wright, S. D. (1994) Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J. Exp. Med. 179, 269-277
6. Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Kuwata, H., Takeuchi, O., Takeshige, K., Saitoh, T., Yamaoka, S., Yamamoto, N., Yamamoto, S., Muta, T., Takeda, K., and Akira, S. (2004) Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430, 218-222
7. Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L., and Aderem, A. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. U. S. A. 97, 13766-13771
8. Reinhart, K., Gluck, T., Ligtenberg, J., Tschaikowsky, K., Bruining, A., Bakker, J., Opal, S., Moldawer, L. L., Axtelle, T., Turner, T., Souza, S., and Pribble, J. (2004) CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit. Care Med. 32, 1100-1108
9. Lynn, W. A., Liu, Y., and Golenbock, D. T. (1993) Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide. Infect. Immun. 61, 4452-4461
10. Gessani, S., Testa, U., Varano, B., Di Marzio, P., Borghi, P., Conti, L., Barberi, T., Tritarelli, E., Martucci, R., Seripa, D., and et al. (1993) Enhanced production of LPS-induced cytokines during differentiation of human monocytes to macrophages. Role of LPS receptors. J. Immunol. 151, 3758-3766
11. Flaherty, S. F., Golenbock, D. T., Milham, F. H., and Ingalls, R. R. (1997) CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin. J. Surg. Res. 73, 85-89
12. Ingalls, R. R., and Golenbock, D. T. (1995) CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J. Exp. Med. 181, 1473-1479
13. Perera, P. Y., Mayadas, T. N., Takeuchi, O., Akira, S., Zaks-Zilberman, M., Goyert, S. M., and Vogel, S. N. (2001) CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J. Immunol. 166, 574-581
14. Wright, S. D., and Jong, M. T. (1986) Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. J. Exp. Med. 164, 1876-1888
15. Gopinath, R. S., Ambagala, T. C., Deshpande, M. S., Donis, R. O., and Srikumaran, S. (2005) Mannheimia (Pasteurella) haemolytica leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18. Infect. Immun. 73, 6179-6182
16. Zhang, L., and Plow, E. F. (1996) Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrin. J. Biol. Chem. 271, 18211-18216
17. Luk, J. M., Kumar, A., Tsang, R., and Staunton, D. (1995) Biotinylated lipopolysaccharide binds to endotoxin receptor in endothelial and monocytic cells. Anal. Biochem. 232, 217-224
18. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59
19. Lee, N. P., Tsang, S., Cheng, R. H., and Luk, J. M. (2006) Increased solubility of integrin betaA domain using maltose-binding protein as a fusion tag. Protein Pept. Lett. 13, 431-435
20. Luk, J. M., Lind, S. M., Tsang, R. S., and Lindberg, A. A. (1991) Epitope mapping of four monoclonal antibodies recognizing the hexose core domain of Salmonella lipopolysaccharide. J. Biol. Chem. 266, 23215-23225
21. Lo, C. Y., Lam, K. Y., Leung, P. P., and Luk, J. M. (2005) High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. Eur. J. Endocrinol. 152, 545-550
22. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489
23. Little, R. G., Kelner, D. N., Lim, E., Burke, D. J., and Conlon, P. J. (1994) Functional domains of recombinant bactericidal/permeability increasing protein (rBPI23). J. Biol. Chem. 269, 1865-1872
24. Battafaraono, R. J., Dahlberg, P. S., Ratz, C. A., Johnston, J. W., Gray, B. H., Haseman, J. R., Mayo, K. H., and Dunn, D. L. (1995) Peptide derivatives of three distinct lipopolysaccharide binding proteins inhibit lipopolysaccharide-induced tumor necrosis factor-alpha secretion in vitro. Surgery 118, 318-324
25. Hoess, A., Watson, S., Siber, G. R., and Liddington, R. (1993) Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 A resolution. EMBO J. 12, 3351-3356
26. Nagaoka, I., Hirota, S., Niyonsaba, F., Hirata, M., Adachi, Y., Tamura, H., and Heumann, D. (2001) Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells. J. Immunol. 167, 3329-3338
27. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680
28. Cuff, J. A., Clamp, M. E., Siddiqui, A. S., Finlay, M., and Barton, G. J. (1998) JPred: a consensus secondary structure prediction server. Bioinformatics 14, 892-893
29. Hall, T. A. (1999) BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl. Acids. Symp. Ser. 41, 95-98
30. Schwede, T., Kopp, J., Guex, N., and Peitsch, M. C. (2003) SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res. 31, 3381-3385
31. Heumann, D., and Roger, T. (2002) Initial responses to endotoxins and Gram-negative bacteria. Clin. Chim. Acta 323, 59-72
32. Moore, K. J., Andersson, L. P., Ingalls, R. R., Monks, B. G., Li, R., Arnaout, M. A., Golenbock, D. T., and Freeman, M. W. (2000) Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J. Immunol. 165, 4272-4280
33. Brandenburg, K., Mayer, H., Koch, M. H., Weckesser, J., Rietschel, E. T., and Seydel, U. (1993) Influence of the supramolecular structure of free lipid A on its biological activity. Eur. J. Biochem. 218, 555-563
34. Ferguson, A. D., Hofmann, E., Coulton, J. W., Diederichs, K., and Welte, W. (1998) Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide. Science 282, 2215-2220
35. Andra, J., Gutsmann, T., Garidel, P., and Brandenburg, K. (2006) Mechanisms of endotoxin neutralization by synthetic cationic compounds. J. Endotoxin. Res. 12, 261-277
36. Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., Ulmer, A. J., Zahringer, U., Seydel, U., Di Padova, F., and et al. (1994) Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8, 217-225
37. Hack, C. E., Aarden, L. A., and Thijs, L. G. (1997) Role of cytokines in sepsis. Adv. Immunol. 66, 101-195
38. Bone, R. C., Balk, R. A., Fein, A. M., Perl, T. M., Wenzel, R. P., Reines, H. D., Quenzer, R. W., Iberti, T. J., Macintyre, N., and Schein, R. M. (1995) A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Crit. Care Med. 23, 994-1006
39. Warren, H. S., Amato, S. F., Fitting, C., Black, K. M., Loiselle, P. M., Pasternack, M. S., and Cavaillon, J. M. (1993) Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide. J. Exp. Med. 177, 89-97