Anterior capsular plaque in congenital cataract: Occurrence, morphology, immunofluorescence, and ultrastructure

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 9, 2007, Pages 4209-4214

  Johar, Kaid ^a,c   Vasavada, Abhay R ^a   Tatsumi, Kouko ^b   Dholakia, Sheena ^a   Nihalani, Bharti ^a   Lakshmana Rao, Sarraju S ^a  

^a Raghudeep Eye Clinic   (India)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c ILADEVI CATARACT AND IOL RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; EOSIN; HEMATOXYLIN; ACTIN;

ADULT; ARTICLE; CATARACT EXTRACTION; CONGENITAL CATARACT; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; IMMUNOFLUORESCENCE; LENS CAPSULE; LENS EPITHELIUM; MAJOR CLINICAL STUDY; MALE; MITOCHONDRION; MORPHOLOGY; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; ROUGH ENDOPLASMIC RETICULUM; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; ADOLESCENT; ANTERIOR EYE SEGMENT; CATARACT; CELL DIFFERENTIATION; CHILD; EPITHELIUM; FLUORESCENT ANTIBODY TECHNIQUE; MESODERM; METABOLISM; PATHOLOGY; PRESCHOOL CHILD;

ACTINS; ADOLESCENT; ALPHA-CRYSTALLIN A CHAIN; ANTERIOR EYE SEGMENT; CATARACT; CATARACT EXTRACTION; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; COLLAGEN TYPE I; COLLAGEN TYPE IV; EPITHELIUM; EXTRACELLULAR MATRIX; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; LENS CAPSULE, CRYSTALLINE; MALE; MESODERM; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 35148897660     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0312     Document Type: Article

References (34)

1. Ramaekers CS, Bloemendal H. Cytoskeletal and contractile structures in lens cell differentiation. In: Bloemendal H, ed. Mol Cell Biol Eye Lens. New York: John Wiley & Sons; 1981:85-136.
2. Zandy AJ, Lakhani S, Zheng T, Flavell RA, Bassnett S. Role of the executioner caspases during lens development. J Biol Chem. 2005;280:30263-30272.
3. Bassnett S, Beebe DC. Coincident loss of mitochondria and nuclei during lens fiber cell differentiation. Dev Dyn. 1992;194:85-93.
4. Lovicu FJ, Ang S, Chorazyczewska M, McAvoy JW. Deregulation of lens epithelial cell proliferation and differentiation during the development of TGFbeta-induced anterior subcapsular cataract. Dev Neurosci. 2004;26:446-455.
5. Saika S, Kono-Saika S, Ohnishi Y, et al. Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol. 2004;164:651-663.
6. Shirai K, Saika S, Tanaka T, et al. A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling. Mol Vis. 2006;12:681-691.
7. Peng Q, Hennig A, Vasavada AR, Apple DJ. Posterior capsular plaque: a common feature of cataract surgery in the developing world. Am J Ophthalmol. 1998;125:621-626.
8. Vasavada AR, Thampi P, Bhatt DS. Degeneration and transdifferentiation of human lens epithelial cells. J Cataract Refract Surg. 1999;25:1312-1313.
9. Marcantonio JM, Syam PP, Liu CS, Duncan G. Epithelial transdifferentiation and cataract in the human lens. Exp Eye Res. 2003;77:339-346.
10. Deane JS, Hall AB, Thompson JR, Rosenthal AR. Prevalence of lenticular abnormalities in a population-based study: Oxford Clinical Cataract Grading in the Melton Eye Study. Ophthalmic Epidemiol. 1997;4:195-206.
11. Frost NA, Sparrow JM, Moore L. Associations of human crystalline lens retrodots and waterclefts with visual impairment: an observational study. Invest Ophthalmol Vis Sci. 2002;43:2105-2109.
12. Joo CK, Lee EH, Kim JC, et al. Degeneration and transdifferentiation of human lens epithelial cells in nuclear and anterior polar cataracts. J Cataract Refract Surg. 1999;25:652-658.
13. Lee EH, Wan XH, Song J, et al. Lens epithelial cell death and reduction of anti-apoptotic protein Bcl-2 in human anterior polar cataracts. Mol Vis. 2002;8:235-240.
14. Rungger-Brandle E, Conti A, Leuenberger PM, Rungger D. Expression of alphasmooth muscle actin in lens epithelia from human donors and cataract patients. Exp Eye Res. 2005;81:539-550.
15. Lovicu FJ, Steven P, Saika S, McAvoy JW. Aberrant lens fiber differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6. Invest Ophthalmol Vis Sci. 2004;45:1946-1953.
16. Pau H, Novotny GE. Ultrastructural investigations on anterior capsular cataract: cellular elements and their relationship to basement membrane and collagen synthesis. Graefes Arch Clin Exp Ophthalmol. 1985;223:41-46.
17. Wunderlich K, Pech M, Eberle AN, Mihatsch M, Flammer J, Meyer P. Expression of connective tissue growth factor (CTGF) mRNA in plaques of human anterior subcapsular cataracts and membranes of posterior capsule opacification. Curr Eye Res. 2000;21:627-636.
18. Ezaki T. Antigen retrieval on formaldehyde-fixed paraffin sections: its potential drawbacks and optimization for double immunostaining. Micron. 2000;31:639-649.
19. Dandona L, Dandona R, Srinivas M, et al. Blindness in the Indian state of Andhra Pradesh. Invest Ophthalmol Vis Sci. 2001;42:908-916.
20. Rahi JS, Sripathi S, Gilbert CE, Foster A. Childhood blindness in India: causes in 1318 blind school students in nine states. Eye. 1995;9:545-550.
21. Wilson ME, Pandey SK, Thakur J. Paediatric cataract blindness in the developing world: surgical techniques and intraocular lenses in the new millennium. Br J Ophthalmol. 2003;87:14-19.
22. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003;112:1776-1784.
23. Nagamoto T, Eguchi G, Beebe DC. Alpha-smooth muscle actin expression in cultured lens epithelial cells. Invest Ophthalmol Vis Sci. 2000;41:1122-1129.
24. Schmitt-Graff A, Pau H, Spahr R, Piper HM, Skalli O, Gabbiani G. Appearance of alpha-smooth muscle actin in human eye lens cells of anterior capsular cataract and in cultured bovine lens-forming cells. Differentiation. 1990;43:115-122.
25. Novotny GE, Pau H. Myofibroblast-like cells in human anterior capsular cataract. Virchows Arch A Pathol Anat Histopathol. 1984;404:393-401.
26. Font RL, Brownstein S. A light and electron microscopic study of anterior subcapsular cataracts. Am J Ophthalmol. 1974;78:972-984.
27. Johar SR, Rawal UM, Jain NK, Vasavada AR. Sequential effects of ultraviolet radiation on the histomorphology, cell density and antioxidative status of the lens epithelium: an in vivo study. Photochem Photobiol. 2003;78:306-311.
28. Vasavada AR, Cherian M, Yadav S, Rawal UM. Lens epithelial cell density and histomorphological study in cataractous lenses. J Cataract Refract Surg. 1991;17:798-804.
29. Colitz CM, Malarkey D, Dykstra MJ, McGahan MC, Davidson MG. Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts. Am J Vet Res. 2000;61:139-143.
30. Wormstone IM. Posterior capsule opacification: a cell biological perspective. Exp Eye Res. 2002;74:337-347.
31. Saika S, Miyamoto T, Tanaka S, et al. Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition. Invest Ophthalmol Vis Sci. 2003;44:2094-2102.
32. Gao D, Hui Y, Ji Q, Bai J, Liu H. Cell density and expression of proliferating cell nuclear antigen (PCNA) in the lens epithelium of children and aging patients with cataract (in Chinese). Zhonghua Yan Ke Za Zhi. 1998;34:355-357.
33. Pandey SK, Ram J, Werner L, et al. Visual results and postoperative complications of capsular bag and ciliary sulcus fixation of posterior chamber intraocular lenses in children with traumatic cataracts. J Cataract Refract Surg. 1999;25:1576-1584.
34. Apple DJ, Solomon KD, Tetz MR, et al. Posterior capsule opacification. Surv Ophthalmol. 1992;37:73-116.