Aberrant lens fiber differentiation in anterior subcapsular cataract formation: A process dependent on reduced levels of Pax6

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 6, 2004, Pages 1946-1953

  Lovicu, Frank J ^a,b   Steven, Philipp ^a,b,d   Saika, Shizuya ^c   McAvoy, John W ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; BETA CRYSTALLIN; CONNEXIN 43; FIBRONECTIN; FILENSIN; MESSENGER RNA; TRANSCRIPTION FACTOR PAX6; TRANSFORMING GROWTH FACTOR BETA; ACTIN; BIOLOGICAL MARKER; CRYSTALLIN; EYE PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR SUBCAPSULAR CATARACT; ARTICLE; BIOPSY; CATARACT; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; IN VITRO STUDY; LENS EPITHELIUM; LENS FIBER; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; EPITHELIUM CELL; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENETICS; LENS; METABOLISM; MIDDLE AGED; MOUSE; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; WISTAR RAT;

ACTINS; ANIMALS; BIOLOGICAL MARKERS; CATARACT; CELL DIFFERENTIATION; CONNEXIN 43; CRYSTALLINS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; EYE PROTEINS; FIBROBLASTS; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION; LENS, CRYSTALLINE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; ORGAN CULTURE TECHNIQUES; PAIRED BOX TRANSCRIPTION FACTORS; RATS; RATS, WISTAR; REPRESSOR PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 3042616799     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-1206     Document Type: Article

References (34)

1. Trokel S. The physical basis for transparency of the crystalline lens. Invest Ophthalmol Vis Sci. 1962;1:493-501.
2. Lang RA, McAvoy JW. Growth factors in lens development. In: Lovicu FJ, Robinson ML, eds. Development of the Ocular Lens. New York: Cambridge University Press. In press.
3. de Iongh RU, Lovicu FJ, Overbeek PA, et al. Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development. 2001;128:3995-4010.
4. Faber SC, Robinson ML, Makarenkova HP, Lang RA. Bmp signaling is required for development of primary lens fiber cells. Development. 2002;129:3727-3737.
5. Belecky-Adams TL, Adler R, Beebe DC. Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation. Development. 2002;129:3795-3802.
6. Wormstone IM, Tamiya S, Anderson I, Duncan G. TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci. 2002;43:2301-2308.
7. Saika S, Miyamoto T, Ishida I, et al. TGFβ-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol. 2002; 86:1428-1433.
8. Lovicu FJ, Schulz MW, Hales AM, et al. TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract. Br J Ophthalmol. 2002;86:220-226.
9. Font RL, Brownstein S. A light and electron microscopic study of anterior capsular cataracts. Am J Ophthalmol. 1974;78:972-984.
10. Novotny GEK, Pau H. Myofibroblast-like cells in human anterior capsular cataracts. Virchows Arch. 1984;404:393-401.
11. Green WR, McDonnell PJ. Opacification of the posterior capsule. Trans Ophthalmol Soc UK. 1985;104:727-739.
12. Liu J, Hales AM, Chamberlain CG, McAvoy JW. Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Invest Ophthalmol Vis Sci. 1994;35:388-401.
13. Hales AM, Schulz MW, Chamberlain CG, McAvoy JW. TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts. Curr Eye Res. 1994;13:885-890.
14. Hales AM, Chamberlain CG, McAvoy JW. Cataract induction in lenses cultured with transforming growth factor-beta. Invest Ophthalmol Vis Sci. 1995;36:1709-1713.
15. Joo CK, Lee EH, Kim JC, et al. Degeneration and transdifferentiation of human lens epithelial cells in nuclear and anterior polar cataracts. J Cataract Refract Surg. 1999;25:652-658.
16. Saika S, Miyamoto T, Ohnishi Y. Histology of anterior capsule opacification with a polyHEMA/HOHEXMA hydrophilic hydrogel intraocular lens compared to poly (methyl methacrylate), silicone, and acrylic lenses. J Cataract Refract Surg. 2003;29:1198-1203.
17. Marcantonio JM, Syam PP, Liu CS, Duncan G. Epithelial transdifferentiation and cataract in the human lens. Exp Eye Res. 2003; 77:339-346.
18. Srinivasan Y, Lovicu FJ, Overbeek PA. Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest. 1998;101:625-634.
19. Hill RE, Favor J, Hogan BL, et al. Mouse small eye results from mutations in a paired-like homeobox-containing gene (published correction in Nature. 1992;20:355-750). Nature. 1991;354:522-525
20. Hill RE, Favor J, Hogan BL, et al. Mouse small eye results from mutations in a paired-like homeobox-containing gene (published correction in Nature. 1992;20:355-750). Nature. 1991;354:522-525
21. Theiler K, Vamum DS, Stevens LC. Development of Dickie's Small Eye, a mutation in the house mouse. Anat Embryol. 1978;155:81-86.
22. Hales AM, Chamberlain CG, McAvoy JW. Susceptibility to TGF-beta2-induced cataract increases with aging in the rat. Invest Ophthalmol Vis Sci. 2000;41:3544-3551.
23. Robinson ML, Overbeek PA, Verran DJ, et al. Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice. Development. 1995;121:505-514.
24. Walther C, Gruss P. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development. 1991;113:1435-1449.
25. Cvekl A, Piatigorsky J. Lens development and crystallin gene expression: many roles for Pax-6. Bioessays. 1996;18:621-630.
26. Duncan MK, Haynes JI, Cvekl A, Piatigorsky J. Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes. Mol Cell Biol. 1998;18:5579-5586.
27. Collinson JM, Quinn JC, Buchanan MA, et al. Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye. Proc Natl Acad Sci USA. 2001;98:9688-9693.
28. Schmitt-Graff A, Pau H, Spahr R, Piper HM, Skalli O, Gabbiani G. Appearance of alpha-smooth muscle actin in human eye lens cells of anterior capsular cataract and in cultured bovine lens-forming cells. Differentiation. 1990;43:115-122.
29. Wormstone IM, Del Rio-Tsonis K, McMahon G, et al. FGF: an autocrine regulator of human lens cell growth independent of added stimuli (published correction in Invest Ophthalmol Vis Sci. 2001;42:1690). Invest Ophthalmol Vis Sci 2001;42:1305-1311
30. Wormstone IM, Del Rio-Tsonis K, McMahon G, et al. FGF: an autocrine regulator of human lens cell growth independent of added stimuli (published correction in Invest Ophthalmol Vis Sci. 2001;42:1690). Invest Ophthalmol Vis Sci 2001;42:1305-1311
31. Schedl A, Ross A, Lee M, et al. Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell. 1996;86:71-82.
32. Pituello F, Yamada G, Gruss P. Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro. Proc Natl Acad Sci USA. 1995;18;92:6952-6956.
33. Davis J, Duncan MK, Robison WG, Piatigorsky J. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J Cell Sci. 2003;116:2157-2167.
34. Grindley JC, Davidson DR, Hill RE. The role of Pax-6 in eye and nasal development. Development. 1995;121:1433-1442.