Deregulation of lens epithelial cell proliferation and differentiation during the development of TGFβ-induced anterior subcapsular cataract

Developmental Neuroscience

Volumn 26, Issue 5-6, 2004, Pages 446-455

  Lovicu, F J ^a,b,c   Ang, S ^a   Chorazyczewska, M ^b   McAvoy, J W ^a,b,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Cataract; Fiber differentiation; Lens cell proliferation; p57 Kip2; TGF FGF

Indexed keywords

CONNEXIN 43; FIBROBLAST GROWTH FACTOR; PROTEIN P57; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; LENS EPITHELIUM; MOUSE; MYOFIBROBLAST; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; CADHERINS; CATARACT; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONNEXIN 43; CYCLIN-DEPENDENT KINASE INHIBITOR P57; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTORS; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LENS, CRYSTALLINE; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR BETA;

EID: 18644367690     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000082286     Document Type: Article

References (26)

1. Cerra A, Mansfield KJ, Chamberlain CG (2003): Exacerbation of TGF-beta-induced cataract by FGF-2 in cultured rat lenses. Mol Vis 9:689-700.
2. Font RL, Brownstein S (1974): A light and electron microscopic study of anterior subcapsular cataracts. Am J Ophthalmol 78:972-984.
3. Gao Y, Spray DC (1998): Structural changes in lenses of mice lacking the gap junction protein connexin 43. Invest Ophthalmol Vis Sci 39:1198-1209.
4. Griep AE, Zhang P (2004): Lens Cell Proliferation: The Cell Cycle; in Lovicu FJ, Robinson ML (eds): Development of the Ocular Lens. New York, Cambridge University Press, pp 191-213.
5. Hales AM, Schulz MW, Chamberlain CG, McAvoy JW (1994): TGF-β1 induces lens cells to accumulate α-smooth muscle actin, a marker for sub-capsular cataracts. Curr Eye Res 13:885-890.
6. Hales AM, Chamberlain CG, McAvoy JW (1995): Cataract induction in lenses cultured with transforming growth factor-β. Invest Ophthalmol Vis Sci 36:1709-1713.
7. Harper JW, Elledge SJ (1996): Cdk inhibitors in development and cancer. Curr Opin Genet Dev 6:56-64.
8. Kurosaka D, Nagamoto T (1994): Inhibitory effect of TGF-beta 2 in human aqueous humor on bovine lens epithelial cell proliferation. Invest Ophthalmol Vis Sci 35:3408-3412.
9. Lang RA, McAvoy JW (2004): Growth Factors In Lens Development; in Lovicu FJ, Robinson ML (eds): Development of the Ocular Lens. New York, Cambridge University Press, pp 261-289.
10. Liu J, Hales MH, Chamberlain CG, McAvoy JW (1994): Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor β. Invest Ophthalmol Vis Sci 35:388-401.
11. Lovicu FJ, Overbeek PA (1998): Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development 125:3365-3377.
12. KIP2 during murine lens development. Mech of Dev 86:165-169.
13. Lovicu FJ, McAvoy JW (2001): FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development 128:5075-5084.
14. Lovicu FJ, Schulz MW, Hales AM, Vincent LN, Overbeek PA, Chamberlain CG, McAvoy JW (2002): TGF beta induces morphological and molecular changes similar to human anterior subcapsular cataract. Br J Ophthalmol 86:220-226.
15. Lovicu FJ, Steven P, Saika S, McAvoy JW (2004): Aberrant lens fiber differentiation contributes to anterior subcapsular cataract formation in vivo: A process dependent on reduced levels of Pax6. Invest Ophthalmol Vis Sci 45:1946-1953.
16. CIP1 cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9:650-662.
17. Robinson ML, Overbeek PA, Verran DJ, Grizzle WE, Stockard CR, Friesel R, Maciag T, Thompson JA (1995): Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice. Development 121:505-514.
18. Saika S, Miyamoto T, Ishida I, Shirai K, Ohnishi Y, Ooshima A, McAvoy JW (2002): TGFbeta-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol 86:1428-1433.
19. Srinivasan Y, Lovicu FJ, Overbeek PA (1998): Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest 101:625-634.
20. Stump RJW, Ang S, Chen Y, von Bahr T, Lovicu FJ, Pinson K, de Iongh RU, Yamaguchi TP, Sasoon DA, McAvoy JW (2003): A role for Wnt/β-catenin signalling in lens epithelial differentiation. Dev Biol 259:48-61.
21. Van Aken E, Papeleu P, De Potter P, De Laey JJ, Mareel M (2000): Cadherin expression in the eye. Bull Soc Belge Ophtalmol 278:55-59.
22. Walther C, Gruss P (1991): Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113:1435-1449.
23. Wormstone IM, Tamiya S, Anderson I, Duncan G (2002): TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci 43:2301-2308.
24. Xu L, Overbeek PA, Reneker LW (2002): Systematic analysis of E-, N- and P-Cadherin expression in mouse eye development. Exp Eye Res 74:753-760.
25. Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev 11:973-983.
26. Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Bottinger EP (2001): Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA 98:6686-6691.