Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: Implication of base excision repair pathways

Carcinogenesis

Volumn 28, Issue 10, 2007, Pages 2089-2095

  Kundu, Chanakya N ^a   Balusu, Ramesh ^a   Jaiswal, Aruna S ^a   Narayan, Satya ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; APC PROTEIN; DEOXYRIBONUCLEASE I; DNA DIRECTED DNA POLYMERASE BETA; SMALL INTERFERING RNA; SULFONIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EMBRYO; APOPTOSIS; ARTICLE; CELL ADHESION; CELL CYCLE REGULATION; CELL FUNCTION; CELL MIGRATION; CHEMOSENSITIVITY; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DNA ALKYLATION; DNA DAMAGE; DRUG EFFICACY; EXCISION REPAIR; FIBROBLAST CULTURE; HYPOTHESIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; DNA REPAIR; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE SILENCING; GENES, APC; METHYL METHANESULFONATE; MICE; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS);

EID: 35148859739     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm125     Document Type: Article

References (46)

1. Peto,R. et al. (1984) Nitrosamine carcinogenesis in 5120 rodents: chronic administration of sixteen different concentrations of NDEA, NDMA, NPYR and NPIP in the water of 4440 inbred rats, with parallel studies on NDEA alone of the effect of age of starting (3, 6 or 20 weeks) and of species (rats, mice or hamsters). IARC Sci. Publ., 57, 627-665.
2. Blasiak,J. et al. (2004) Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. Mutat Res., 554, 139-148.
3. Spiro,T.P. et al. (1999) O(6)-benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. Cancer Res., 59, 2402-2410.
4. Ochs,K. et al. (1999) Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Cancer Res., 59, 1544-1551.
5. Engelward,B.P. et al. (1996) Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. EMBO J., 15, 945-952.
6. Kaina,B. et al. (1993) Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen, 22, 283-292.
7. Beranek,D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res., 231, 11-30.
8. Friedberg,E.C. et al. (1995) DNA Repair and Mutagenesis. ASM Press, Washington, DC, 191-232.
9. Beard,W.A. et al. (2006) Structure and mechanism of DNA polymerase beta. Chem. Rev., 106, 361-382.
10. Frosina,G. et al. (1996) Two pathways for base excision repair in mammalian cells. J. Biol. Chem., 271, 9573-9578.
11. Fromme,J.C. et al. (2004) DNA glycosylase recognition and catalysis. Curr Opin. Struct. Biol., 4, 43-49.
12. Christmann,M. et al. (2003) Mechanisms of human DNA repair: An update. Toxicology, 193, 3-34.
13. Stucki,M. et al. (1998) Mammalian base excision repair by DNA polymerases delta and epsilon. Oncogene, 17, 835-843.
14. Bentley,D. et al. (1996) DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Nat. Genet., 13, 489-491.
15. Gu,H. et al. (1994) Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science, 265, 103-106.
16. Sobol,R.W. et al. (1996) Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature, 379, 183-186.
17. Powell,S.M. et al. (1992) APC mutations occur early during colorectal tumorigenesis. Nature, 359, 235-237.
18. Fearnhead,N.S.et al. (2001) The ABC of APC. Hum. Mol. Genet. 10, 721-733.
19. Jaiswal,A.S. et al. (2004) Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. J. Cancer Res. Clin. Oncol., 130, 695-703.
20. Hall,P.A. et al. (1994) Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis. J. Cell Sci., 107, 3569-3577.
21. Kaplan,K.B. et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol., 3, 429-432.
22. Jaiswal,A.S. et al. (2006) Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair. Biochemistry, 45, 15903-15914.
23. Jaiswal,A.S. et al. (2005) Involvement of adenomatous; polyposis coli in colorectal tumorigenesis. Front. Biosci., 10, 1118-1134.
24. Kundu,C.N. et al. (2007) Cigarette smoke condensate-induced level of adenomatous polyposis coli blocks long-patch base excision repair in breast epithelial cells. Oncogene, 26, 1428-1438.
25. Narayan,S. et al. (2005) Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. J. Biol. Chem., 280, 6942-6949.
26. Jaiswal,A.S. et al. (2001) p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents. J. Biol. Chem., 276, 18193-18199.
27. Jaiswal,A.S. et al. (2006) 12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APQ gene expresion in normal breast epithelial cells is mediated by GC-box binding protein Sp3. Carcinogenesis, 27, 252-261.
28. Narayan,S. et al. (1997) Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine requires p53. J. Biol. Chem., 272, 30619-30622.
29. Sobol,R.W. et al. (2000) The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity. Nature, 405, 807-810.
30. Shapiro,D.J. et al. (1988) A high-efficiency HeLa cell nuclear transcription extract. DNA, 7, 47-55.
31. Shortle,D. et al. (1983) Directed mutagenesis with sodium bisulfite. Methods Enzymol., 100, 457-468.
32. Jaiswal,A.S. et al. (2002) Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines. treated with plumbagin: Involvement of cyclin-dependent kinase inhibitor p21Waf-I/Cip-1. Oncogene, 21 5912-5922.
33. Vindelov,L. et al. (1990) A review of techniques and results obtained in one laboratory by an integrated system of methods designed for routine clinical flow cytometric DNA analysis. Cytometry, 11, 753-770.
34. Narayan,S. et al. (2001) DNA damage-induced cell cycle checkpoints involve both p53-dcpendent and independent pathways: Role of telomere repeat binding factor 2. Br J. Cancer, 85, 898-901.
35. Horton,J.K. et al. (2000) Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. J. Biol. Chem., 275, 2211-2218.
36. Fornace,AJ. et al. (1989) Induction of β-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells. Mol. Cell. Biol. 9, 851-853.
37. Fortini,P. et al. (1998) Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Biochemistry, 37, 3575-3580.
38. Biade,S. et al. (1998) Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. J. Biol. Chem., 273, 898-902.
39. Sobol,R.W. et al. (2002) Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc. Natl. Acad Sci. USA, 99, 6860-6865.
40. Sobol,R.W. et al. (2003) Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. DNA Repair (Amst.), 2, 609-622.
41. Bebenek,K. et al. (2001) 5′,-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Science, 291 2156-2159.
42. Garcia-Diaz,M. et al. (2001) Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: A possible role in base excision repair. J. Biol. Chem., 276, 34659-34663.
43. Prasad,R. et al., (2003) Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. J. Biol. Chem., 278, 29649-29654.
44. Trivedi,R.N. et al. (2005) The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res., 65, 6394-6400.
45. Jeggo,P.A. et al. (2006) Contribution of DNA repair and cell cycle check-point arrest to the maintenance of genomic stability. DNA Repair (Amst.), 8, 1192-1198.
46. Sanchez-Perez,I. (2006) DNA repair inhibitors in cancer treatment. Clin. Transl. Oncol., 8, 642-646.