Leptin stimulates α1(I) collagen expression in human hepatic stellate cells via the phosphatidylinositol 3-kinase/Akt signalling pathway

Liver International

Volumn 27, Issue 9, 2007, Pages 1265-1272

  Niu, Liwen ^a,b   Wang, Xiaohong ^a   Li, Jun ^a   Huang, Yan ^a   Yang, Zhen ^a   Chen, Feihu ^a   Ni, Hongchang ^a   Jin, Yong ^a   Lu, Xiongwen ^a   Cao, Qi ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Akt; Hepatic fibrosis; Leptin; Phosphatidylinositol 3 kinase (PI3K)

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA; JANUS KINASE 1; LEPTIN; MESSENGER RNA; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN P85 ALPHA; UNCLASSIFIED DRUG; WORTMANNIN; ENZYME INHIBITOR;

ARTICLE; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; FIBROGENESIS; GENE EXPRESSION REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; LIVER CELL; LIVER FIBROSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STELLATE CELL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; CELLS, CULTURED; COLLAGEN TYPE I; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; LEPTIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 35148815710     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2007.01582.x     Document Type: Article

References (34)

1. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-70.
2. Honda H, Ikejima K, Hirose M, et al. Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology 2002; 36: 12-21.
3. Saxena N, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 2002; 35: 762-71.
4. Potter JJ, Rennie-Tankesley L, Mezey E. Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol 2003; 38: 281-8.
5. Ikejima K, Takei Y, Honda H, et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002; 122: 1399-410.
6. Saxena N, Saliba G, Floyd JJ, Anania FA. Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells. J Cell Biochem 2003; 89: 311-20.
7. Cao Q, Mak KM, Lieber CS. DLPC and SAMe prevent α1(I)collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione. Biochem Biophys Res Commun 2006; 350: 50-5.
8. 2-dependent MAPK pathways. J Cell Biochem 2006; 97: 188-97.
9. Valius M, Kazlauskas A. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 1993; 73: 321-34.
10. Kundra V, Escobedo JA, Kazlauskas A, et al. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature 1994; 367: 474-6.
11. Yao R, Cooper GM. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995; 267: 2003-6.
12. Parker PJ, Waterfield MD. Phosphatidylinositol 3-kinase: A novel effector. Cell Growth Differ 1992; 3: 747-52.
13. Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999; 68: 965-1014.
14. Madge LA, Pober JS. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFκB in human endothelial cells. J Biol Chem 2000; 275: 15458-63.
15. Kulik G, Klippel A, Weber MJ. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 1997; 17: 1595-606.
16. Lang T, Ikejima K, Yoshikawa M, et al. Leptin facilitates proliferation of hepatic stellate cells through up-regulation of platelet-derived growth factor receptor. Biochem Biophys Res Commun 2004; 323: 1091-5.
17. Lechuga CG, Hernández-Nazara ZH, Rosales J-AD, et al. TGF-β1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70 S6k. Am J Physiol Gastrointest Liver Physiol 2004; 287: G974-87.
18. Reif S, Lang A, Lindquist JN, et al. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 2003; 278: 8083-90.
19. Takahashi M, Matsui A, Inao M, Mochida S, Fujiwara K. ERK/MAPK-dependent PI3K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells. Hepatol Res 2003; 26: 232-6.
20. Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-8.
21. Sweeney G, Niu W, Kanani R, Klip A. Regulation of the Na,K-pump by leptin in 3T3-L1 fibroblasts. Endocrinology 2000; 141: 1277-80.
22. Martin-Romero C, Sanchez-Margalet V. Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: Possible role of Sam68. Cell Immunol 2001; 212: 83-91.
23. Zhao AZ, Shinohara MM, Huang D, et al. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 2000; 275: 11348-54.
24. Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes via Janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 1997; 40: 1358-62.
25. Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-95.
26. Burysek L, Syrovets T, Simmet T. The serine protease plasmin triggers expression of MCP-1 and CD-40 in human primary monocytes via activation of p38 MAPK and JAK/STAT signaling pathway. J Biol Chem 2002; 277: 33509-17.
27. Marra F, Pinzani M, DeFranco R, Laffi G, Gentilini P. Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells. FEBS Lett 1995; 376: 141-5.
28. Kobayashi S, Werneburg NW, Bronk SF, Kaufmann SH, Gores GJ. Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. Gastroenterology 2005; 128: 2054-65.
29. Cao Q, Mak KM, Lieber CS. Dilinoleoylphosphatidylcholine prevents transforming growth factor-β-1-mediated collagen accumulation in cultured rat hepatic stellate cells. J Lab Clin Med 2002; 139: 202-10.
30. Choudhury J, Mirshahi F, Murthy KS, Yager DR, Sanyal AJ. Physiologic concentrations of leptin increases collagen production by non-immortalized human hepatic cells. Metabolism 2006; 55: 1317-22.
31. Shegogue D, Trojanowska M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem 2004; 279: 23166-75.
32. Meyers R, Cantley LC. Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem 1997; 272: 4384-90.
33. Ricupero DA, Poliks CF, Rishikof DC, Cuttle KA, Kuang P-P, Goldstein RH. Phosphatidylinositol 3-kinase-dependent stabilization of α1(I) collagen mRNA in human lung fibroblasts. Am J Physiol Cell Physiol 2001; 281: C99-105.
34. Hartley KO, Gell D, Smith GC, et al. DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995; 82: 849-56.