Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-β compared with IFN-α

Journal of Interferon and Cytokine Research

Volumn 19, Issue 7, 1999, Pages 797-801

  Grumbach, Isabella M ^a   Fish, Eleanor N ^b   Uddin, Shahab ^a   Majchrzak, Beata ^a   Colamonici, Oscar R ^c   Figulla, Hans R ^d   Heim, Albert ^e   Platanias, Leonidas C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; PROTEIN KINASE; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; COMPLEX FORMATION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FIBROBLAST CULTURE; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANTIVIRAL AGENTS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; JANUS KINASE 3; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0032787607     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099313659     Document Type: Article

References (24)

1. PESTKA, S., LANGER, J.A., ZOOM, K.C., and SAMUEL, C.E. (1987). Interferons and their actions. Annu. Rev. Biochem. 56, 727-777.
2. PLATANIAS, L.C. (1995). Interferons. Laboratory to clinic investigations. Curr. Opin. Oncol. 7, 560-565.
3. COLAMONICI, O.R., PFEFFER. L.M., D'ALESSANDRO, F., PLATANIAS, L.C., GREGORY, S.A., ROSOLEN, A., NORDAN, R., CRUCIANI, R.A., and DIAZ, M.O. (1992). Multichain structure of the IFN-alpha receptor on hematopoietic cells. J. Immunol. 148, 2126-2132.
4. COLAMONICI, O.R., and DOMANSKI, P. (1993). Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J. Biol. Chem. 268, 10895-10899.
5. PLATANIAS, L.C., PFEFFER, L.M., CRUCIANI, R., and COLAMONICI, O.R. (1993). Characterization of the α-subunit of the interferon α receptor. Evidence for N- and O-glycosylation and association with other proteins. J. Immunol. 150, 3382-3388.
6. UZÉ, G., LUTFALLA, G., and GRESSER, I. (199). Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 60, 225-234.
7. DOMANSKI, P., WITTE, M., KELLUM, M., RUBINSTEIN, M., HACKETT, R., PITHA, P., and COLAMONICI, O.R. (1995). Cloning and expression of a long form of the beta subunit of the interferon alpha/beta receptor that is required for signaling. J. Biol. Chem. 270, 21606-21611.
8. LUTFALLA, G., HOLLAND, S.J., CINATO, E., MONNERON, D., REBOUL, J., ROGERS. N.C., SMITH, J.M., STARK, G.R., GARDINER, K., MOGENSEN, K.E., KERR, I.M., and UZE, G. (1995). Mutant U5A cells are complemented by an interferon-alpha/beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14, 5100-5108.
9. NOVICK, D., COHEN, B., and RUBINSTEIN, M. (1994). The human interferon α/β receptor: characterization and molecular cloning. Cell. 77, 391-400.
10. STARK, G.R., KERR, I.M., WILLIAMS, B.R., SILVERMAN, R.H., and SCHREIBER, R.D. (1998). How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264.
11. UDDIN, S., YENUSH, L., SUN, X.-J., SWEET, M.E., WHITE, M.F., and PLATANIAS, L.C. (1995). Interferon a engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3′-kinase. J. Biol. Chem. 270, 15938-15941.
12. PLATANIAS, L.C., UDDIN, S., YETTER, A., SUN, X.-J., and WHITE, M.F. (1996). The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate-2. J. Biol. Chem. 271, 278-282.
13. PLATANIAS, L.C., and SWEET, M.E. (1994). Interferon α induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells. J. Biol. Chem. 269, 3143-3146.
14. AHMAD, S., ALSAYED, Y., DRUKER, B.J., and PLATANIAS, L.C. (1997). The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. J. Biol. Chem. 272, 29991-29994.
15. L subunits of the type I interferon receptor. J. Biol. Chem. 271, 23630-23633.
16. CROZE, R., RUSSEL-HARDE, D., WAGNER, T.C., PU, H., PFEFFER, L.M., and PEREZ, H.D. (1996). The type I interferon receptor. Identification of the interferon β-specific receptor-associated phosphoprotein. J. Biol. Chem. 271, 33165-33168.
17. VELAZQUEZ, L., FELLOUS, M., STARK, G.R., and PELLEGRINI, S. (1992). A protein tyrosine kinase in the interferon α/β signaling pathway. Cell 70, 313-322.
18. RAM, M.R.S., LEAMAN, D., LEUNG, S., STARK, G.R., and RANSOHOFF, M. (1996). Characterization of β-R1, a gene that is selectively induced by interferon-β (IFN-β) compared with IFN-α. J. Biol. Chem. 13, 22878-22884.
19. HEIM, A., STILLE-SIEGENER, M., PRING-AKERBLOM, P., GRUMBACH, I., BREHM, C., KREUZER, H., and FIGULLA, H.-R. (1996). Recombinant interferons βand γ have a higher antiviral activity than interferon-α in coxsackievirus B3-infected carrier state cultures of human myocardial fibroblasts. J. Interferon Cytokine Res. 16, 283-287.
20. HEIM, A., BREHM, C., STEILLE-SIEGNER, M., MULLER, G., HAKE, S., KANDOLF, R., and FIGULLA, H.-R. (1995). Cultured human myocardial fibroblasts of pediatric origin: natural human interferon-α is more effective than recombinant interferon-α2a in carrier-state coxsackievirus B3 replication. J. Mol. Cell. Cardiol. 27, 2199-2208.
21. WONG, M., and FISH, E.N. (1998). RANTES and MIP-1 alpha activate Stats in T-cells. J. Biol. Chem. 273, 309-314.
22. UDDIN, S., FISH, E.N., SHER, D., GARDZIOLA, C., COLAMONICI, O.R., KELLUM, M., PITHA, P.M., WHITE, M.F., and PLATANIAS, L.C. (1997). The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-a receptors. Blood 90, 2574-2582.
23. BROMBERG, J.F., HORVATH, C.M., WEN, Z., SCHREIBER, R.D, and DARNELL, I.E., JR. (1996). Transcriptionally active Statl is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc. Natl. Acad. Sci. USA 93, 7673-7678.
24. DOMANSKI, P., NADEAU, O.W., PLATANIAS, L.C., FISH, E., KELLUM, M., PITHA, P., and COLAMONICI, O.R. (1998). Differential use of the betaL subunit of the type I interferon (IFN) receptor determines signaling specificity for IFN alpha2 and IFN beta. J. Biol. Chem. 273, 3144-3147.