Inferring somatic mutation rates using the stop-enhanced green fluorescent protein mouse

Genetics

Volumn 177, Issue 1, 2007, Pages 9-16

  Ro, Simon ^a   Rannala, Bruce ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA; GREEN FLUORESCENT PROTEIN; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOOTSTRAPPING; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; MUTAGENICITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SIMULATION; SOMATIC MUTATION; STOCHASTIC MODEL;

ANIMALS; CODON, TERMINATOR; ETHYLNITROSOUREA; GREEN FLUORESCENT PROTEINS; LIVER; MICE; MODELS, BIOLOGICAL; MUTAGENICITY TESTS; MUTAGENS; MUTATION; STEM CELLS;

MUS; MUS MUSCULUS;

EID: 35048848528     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.106.069310     Document Type: Article

References (33)

1. BALLING, R., 2001 ENU mutagenesis: analyzing gene function in mice. Annu. Rev. Genomics Hum. Genet. 2: 463-492.
2. BECKMAN, R., and L. A. LOEB, 2006 Efficiency of carcinogenesis with and without a mutator mutation. Proc. Natl. Acad. Sci. USA 103: 14140-14145.
3. BUETTNER, V. L., K. A. HILL, H. NISHINO, D. J. SCHAID, C. S. FRISK et al., 1996 Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice. Oncogene 13: 2407-2413.
4. TM mouse: results of the collaborative study on the transgenic mutation assay by JEMS/MMS. Environ. Mol. Mutagen. 28: 363-375.
5. DEAN, S. W., T. M. BROOKS, B. BURLINSON, J. MIRSALIS, B. MYHR et al., 1999 Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens. Mutagenesis 14: 141-151.
6. DOUGLAS, G. R., J. JIAO, J. D. GINGERICH, L. M. SOPER and J. A. GOSSEN, 1996 Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ. Mol. Mutagen. 28: 317-324.
7. DRAKE, J., 1970 The Molecular Basis of Mutation. Holden-Day, San Francisco.
8. GORBUNOVA, V., and A. SELUANOV, 2005 Making ends meet in old age: dsb repair and aging. Mech. Ageing Dev. 126: 621-628.
9. GOSSEN, J. A., W. J. DE LEEUW, C. H. TAN, E. C. ZWARTHOFF, F. BERENDS et al., 1989 Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86: 7971-7975.
10. HANAHAN, D., and R. A. WEINBERG, 2000 The hallmarks of cancer. Cell 100: 57-70.
11. HEDDLE, J. A., 1999a Mutant manifestation: the time factor in somatic mutagenesis. Mutagenesis 14: 257-260.
12. HEDDLE, J. A., 1999b Mutant manifestation: the time factor in somatic mutagenesis. Mutagenesis 14: 1-3.
13. JAKUBCZAK, J. L., G. MERLINO, J. E. FRENCH, W. J. MULLER, B. PAUL et al., 1996 Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. Proc. Natl. Acad. Sci. USA 93: 9073-9078.
14. JUSTICE, M. J., D. A. CARPENTER, J. FAVOR, A. NEUHAUSER-KLAUS, M. HRABE DE ANGELIS et al., 2000 Effects of ENU dosage on mouse strains. Mamm. Genome 11: 484-488.
15. KOHLER, S. W., G. S. PROVOST, A. FIECK, P. L. KRETZ, W. O. BULLOCK et al., 1991 Spectra of spontaneous and mutagen-induced mutations in the laci gene in transgenic mice. Proc. Natl. Acad. Sci. USA 88: 7958-7962.
16. NOWELL, P. C., 1976 The clonal evolution of tumor cell populations. Science 194: 23-28.
17. PONDER, B. A., 2001 Cancer genetics. Nature 411: 336-341.
18. RO, S., 2004 Magnifying stem cell lineages: the stop-EGFP mouse. Cell Cycle 3: 1246-1249.
19. RO, S., and B. RANNALA, 2004 A stop-EGFP transgenic mouse to detect clonal cell lineages generated by mutation. EMBO Rep. 5: 914-920.
20. RO, S., and B. RANNALA, 2005 Evidence from the stop-EGFP mouse supports a niche-sharing model of epidermal proliferative units. Exp. Dermatol. 14: 838-843.
21. SEDELNIKOVA, O. A., I. HORIKAWA, D. B. ZIMONJIC, N. C. POPESCU, W. M. BONNER et al., 2004 Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6: 168-170.
22. SKOPEK, T. R., 1998 Transgenic mutation models: research, testing, and reality checks. Environ. Mol. Mutagen. 32: 104-105.
23. SNUSTAD, D., and M. SIMMONS, 2006 Principles of Genetics. John Wiley & Sons, Hoboken, NJ.
24. SUN, B., and J. A. HEDDLE, 1999 The relationship between mutant frequency and time in vivo: simple predictions for any tissue, cell type, or mutagen. Mutat. Res. 425: 179-183.
25. SUZUKI, T., S. ITOH, M. NAKAJIMA, N. HACHIYA and T. HARA, 1999 Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS. Mutat. Res. 444: 259-268.
26. THOMPSON, J. N. J., R. C. WOODRUFF and H. HUAI, 1998 Mutation rate: a simple concept has become complex. Environ. Mol. Mutagen. 32: 292-300.
27. THYBAUD, V., S. DEAN, T. NOHMI, J. DE BOER, G. R. DOUGLAS et al., 2003 In vivo transgenic mutation assays. Mutat. Res. 540: 141-151.
28. WANG, J., X. LIU, R. H. HEFLICH and T. CHEN, 2004 Time course of cII gene mutant manifestation in the liver, spleen, and bone marrow of N-ethyl-N-nitrosourea-treated Big Blue transgenic mice. Toxicol. Sci. 82: 124-128.
29. WIJNHOVEN, S. W. P., and H. VAN STEEG, 2003 Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesis. Toxicology 193: 171-187.
30. WINTER, D. B., and P. J. GEARHART, 2001 Altered spectra of hypermutation in DNA repair-deficient mice. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356: 5-11.
31. YAMADA, T. R., R. YAMAMOTO, H. KANEKO and A. YOSHITAKE, 1999 Ethylnitrosourea-induced mutation and molecular analysis of transgenic mice containing the gpt shuttle vector. Mutat. Res. 441: 59-72.
32. YANG, T. T., L. CHENG and S. R. KAIN, 1996 Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein. Nucleic Acids Res. 24: 4592-4593.
33. YANG, Z., S. RO and B. RANNALA, 2003 Likelihood models of somatic mutation and codon substitution in cancer genes. Genetics 165: 695-705.