The Aging Gut: Physiology

Clinics in Geriatric Medicine

Volumn 23, Issue 4, 2007, Pages 757-767

  Morley, John E ^a,b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GASTROINTESTINAL HORMONE; GASTROINTESTINAL POLYPEPTIDE;

AGING; ANOREXIA; DYSPHAGIA; ESOPHAGUS FUNCTION; GALLBLADDER; GASTROINTESTINAL MOTILITY; HUMAN; HYPOTENSION; INTESTINE; INTESTINE ABSORPTION; INTESTINE FLORA; LIVER; PANCREAS; REVIEW; STOMACH ACID; STOMACH MUCOSA;

AGING; ANOREXIA; BLOOD PRESSURE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HUMANS; INTESTINAL ABSORPTION; POSTPRANDIAL PERIOD;

EID: 34948886752     PISSN: 07490690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cger.2007.06.002     Document Type: Review

References (101)

1. Morley J.E., Thomas D.R., and Wilson M.M. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr 83 (2006) 735-743
2. Morley J.E., and Silver A.J. Anorexia in the elderly. Neurobiol Aging 9 (1988) 9-16
3. Morley J.E. Anorexia of aging: physiologic and pathologic. Am J Clin Nutr 66 (1997) 760-773
4. Boyce J.M., and Shone G.R. Effects of ageing on smell and taste. Postgrad Med J 82 (2006) 239-241
5. Weiffenbach J.M., Cowart B.J., and Baum B.J. Taste intensity perception in aging. J Gerontol 41 (1986) 460-468
6. Matsuda T., and Doty R.L. Regional taste sensitivity to NaCl: relationship to subject age, tongue locus and area of stimulation. Chem Senses 20 (1995) 283-290
7. Schiffman S.S. Taste and smell losses with age. Bol Asoc Med P R 83 (1991) 411-414
8. Jones K.L., Doran S.M., Hveem K., et al. Relation between postprandial satiation and antral area in normal subject. Am J Clin Nutr 66 (1997) 127-132
9. Morley J.E., Kumar V.B., Mattammal M.B., et al. Inhibition of feeding by a nitric oxide synthase inhibitor: effects of aging. Eur J Pharmacol 31 (1996) 15-59
10. Sun W.M., Doran S., Lingenfelser T., et al. Effects of glyceryl trinitrate on the pyloric motor response to intraduodenal triglyceride infusion in humans. Eur J Clin Invest 26 (1996) 657-664
11. Sun W.M., Doran S., Jones K.L., et al. Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility. Am J Physiol 275 5 Pt I (1998) G1173-G1178
12. Rolland Y., Kim M.J., Gammack J.K., et al. Office management of weight loss in older persons. Am J Med 119 (2006) 1019-1026
13. Morley J.E. Minireview. The ascent of cholecystokinin (CCK)-from gut to brain. Life Sci 30 (1982) 479-493
14. Silver A.J., Flood J.F., Song A.M., et al. Evidence for a physiological role for CCK in the regulation of food intake in mice. Am J Physiol 256 3 Pt 2 (1989) R646-R652
15. McIntosh C.G., Horowitz M., Verhagen M.A., et al. Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men. Am J Gastroenterol 96 (2001) 997-1007
16. MacIntosh C.G., Andrews J.M., Jones K.L., et al. Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility. Am J Clin Nutr 69 (1999) 999-1006
17. McIntosh C.G., Morley J.E., Wishart J., et al. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 86 (2001) 5830-5837
18. Silver A.J., Flood J.F., and Morley J.E. Effect of gastrointestinal peptides on ingestion in old and young mice. Peptide 9 (1988) 221-225
19. Morley J.E., Perry III H.M., Baumgartner R.P., et al. Leptin, adipose tissue and aging-is there a role for testosterone?. J Gerontol A Biol Sci Med Sci 54 (1999) B99-B107
20. Perry III H.M., Morley J.E., Horowitz M., et al. Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels. Metabolism 46 (1997) 1399-1405
21. Sih R., Morley J.E., Kaiser F.E., et al. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 82 (1997) 1661-1667
22. Wilson M.M., and Morley J.E. Aging and energy balance (review). J Appl Physiol 95 (2003) 1728-1736
23. Morley J.E., and Flood J.F. Evidence that nitric oxide modulates food intake in mice. Life Sci 49 (1991) 707-711
24. Farr S.A., Banks W.A., Kumar V.B., et al. Orexin-A-induced feeding is dependent on nitric oxide. Peptides 26 (2005) 759-765
25. Morimoto S., Okaishi K., Onishi M., et al. Deletion allele of the angiotensin-converting enzyme gene as a risk factor for pneumonia in elderly patients. Am J Med 112 (2002) 89-94
26. Gaskin F.S., Farr S.A., Banks W.A., et al. Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24 (2003) 913-918
27. Morley J.E., Alshaher M.M., Farr S.A., et al. Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides 20 (1999) 595-600
28. Morley J.E. Is weight loss harmful to older men?. Aging Male 9 (2006) 135-137
29. Thomas D.R., Zdrowski C.D., Wilson M.M., et al. Malnutrition in subacute care. Am J Clin Nutr 75 (2002) 308-313
30. Chapman I.M., MacIntosh C.G., Morley J.E., et al. The anorexia of aging. Biogerontology 3 (2002) 67-71
31. Morley J.E., Perry III H.M., and Miller D. Editorial: something about frailty. J Gerontol A Biol Sci Med Sci 57 (2002) M698-M704
32. Morley J.E. Anorexia, sarcopenia and aging. Nutrition 17 (2001) 660-663
33. Morley J.E., and Baumgartner R.N. Cytokine-related aging process. J Gerontol A Biol Sci Med Sci 59 (2004) M924-M929
34. Morley J.E., Kim M.J., Haren M.T., et al. Frailty and the aging male. Aging Male 8 (2005) 135-140
35. Morley J.E., Haren M.T., Rolland Y., et al. Frailty. Med Clin North Am 90 (2006) 837-847
36. Roubenoff R. Catabolism of aging: is it an inflammatory process?. Curr Opin Clin Nutr Metab Care 6 (2003) 295-299
37. Morley J.E. Postprandial hypotension-the ultimate Big Mac attack. [editorial]. J Gerontol A Biol Sci Med Sci 56 (2001) M741-M743
38. Jansen R.W., Kelly-Gagnon M.M., and Lipsitz L.A. Intraindividual reproducibility of postprandial and orthostatic blood pressure changes in older nursing-home patients: relationship with chronic use of cardiovascular medications. J Am Geriatr Soc 44 (1996) 383-389
39. Jones K.L., Tonkin A., Horowitz M., et al. Rate of gastric emptying is a determinant of postprandial hypotension in non-insulin-dependent diabetes mellitus. Clin Sci 94 (1998) 65-70
40. Gentilcore D., Jones K.L., O'Donovan D.G., et al. Postprandial hypotension-novel insights into pathophysiology and therapeutic implications. Curr Vasc Pharmacol 4 (2006) 161-171
41. Jones K.L., O'Donovan D., Russo A., et al. Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects. Am J Physiol Gastrointest Liver Physiol 289 (2005) G240-G248
42. Jansen R.W., and Lipsitz L.A. Postprandial hypotension: epidemiology, pathophysiology, and clinical management. Ann Intern Med 122 (1995) 286-295
43. Edwards B.J., Perry III H.M., Kaiser F.E., et al. Relationship of age and calcitonin gene-related peptide to postprandial hypotension. Mech Ageing Dev 87 (1996) 61-73
44. Gentilcore D., Visvanathan R., Russo A., et al. Role of nitric oxide mechanisms in gastric emptying of, and the blood pressure and glycemic responses to, oral glucose in healthy older subjects. Am J Physiol Gastrointest Liver Physiol 288 (2005) G1227-G1232
45. Kim M.J., Rolland Y., Cepeda O., et al. Diabetes mellitus in older men. Aging Male 9 (2006) 139-147
46. Gentilcore D., Bryant B., Wishart J.M., et al. Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly. Am J Med 118 (2005) 1289
47. Shaker R., Ren J., Bardan E., et al. Pharyngoglottal closure reflex: characterization in healthy young, elderly and dysphagic patients with predeglutitive aspiration. Gerontology 49 (2003) 12-20
48. Stephen J.R., Taves D.H., Smith R.C., et al. Bolus location at the initiation of the pharyngeal stage of swallowing in healthy older adults. Dysphagia 20 (2005) 266-272
49. Ren J., Shaker R., Zamir Z., et al. Effect of age and bolus variables on the coordination of the glottis and upper esophageal sphincter during swallowing. Am J Gastroenterol 88 (1993) 665-669
50. Bardan E., Kern M., Arndorfer R.C., et al. Effect of aging on bolus kinematics during the pharyngeal phase of swallowing. Am J Physiol Gastrointest Liver Physiol 290 (2006) G458-G465
51. Cook I.J., Weltman M.D., Wallace K., et al. Influence of aging on oral-pharyngeal bolus transit and clearance during swallowing: scintigraphic study. Am J Physiol 266 6 Pt 1 (1994) G972-G977
52. Katsumata U., Sekizawa K., and Ebihara T. Aging effects on the cough reflex. Chest 107 (1995) 290-291
53. Ebihara S., Saito H., Kanda A., et al. Impaired efficacy of cough in patients with Parkinson disease. Chest 124 (2003) 1009-1015
54. Ebihara T., Takahashi H., Ebihara S., et al. Capsaicin troche for swallowing dysfunction in older people. J Am Geriatr Soc 53 (2005) 824-828
55. Skidgel R.A., and Erdos E.G. Cleavage of peptide bonds by angiotensin I converting enzymes. Agents Actions Suppl 22 (1987) 289-307
56. Okaishi K., Morimoto S., Fukuo K., et al. Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients. Am J Hypertens 12 8 Pt 1 (1999) 778-783
57. Nakayama K., Sekizawa K., and Sasaki H. ACE inhibitor and swallowing reflex. Chest 113 (1998) 1425-1427
58. Yoneyama T., Yoshida M., Ohrui T., et al. Oral care reduces pneumonia in older patients in nursing homes. J Am Geriatr Soc 50 (2002) 430-433
59. Soergel K.H., Zboralske F.F., and Amberg J.E. Presbyesophagus: esophageal motility in nonagenarians. Clin Invest 43 (1964) 1472-1479
60. Orr W.L., and Chen L.L. Aging and neural control of the GI tract: IV clinical and physiological aspects of gastrointestinal motility and aging. J Physiol 540 (2002) 673-679
61. Shaw D.W., Cook I.J., and Gabb M. Influence of normal aging on oral pharyngeal and upper esophageal sphincter function during swallowing. Am J Physiol 268 (1995) G238-G296
62. Smout A.J., Breedig K.M., van der Zouw L., et al. Physiological gastroesophageal reflux and esophageal motor activity studied with a new system for 24 hour recording and automated analysis. Dig Dis Sci 34 (1981) 372-378
63. Clarkston W.K., Pantano M.M., Morley J.E., et al. Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Physiol 272 1 Pt 2 (1997) R243-R248
64. Madsen J.L., and Graff J. Effects of ageing on gastrointestinal motor function. Age and Ageing 33 (2004) 154-159
65. Husebye E., and Engedal K. The patterns of motility are maintained in the human small intestine throughout the process of aging. Scand J Gastroenterol 27 (1992) 347-406
66. Vagra F. Transit time changes with age in the gastrointestinal tract of the rat. Digestion 14 (1976) 319-324
67. McDougal J.N., Miller M.S., Banks T.F., et al. Age related changes in colonic function in rats. Am J Physiol 274 (1984) 9542-9546
68. Wade P.R., and Cowen T. Neurodegeneration: a key factor in the ageing gut. Neurogastroenterol Motil 16 Suppl 1 (2004) 19-23
69. Knowles C.H., Nickols C.D., Scott S.M., et al. Smooth muscle inclusion bodies in slow transit constipation. J Pathol 193 (2001) 390-397
70. Knowles C.H., Nickols C.D., Feakins R., et al. A systematic analysis of polyglucosan bodies in the human gastrointestinal tract in health and disease. Acta Neuropathol (Berl) 105 (2003) 410-413
71. Tariq S.H., Morley J.E., and Prather C.M. Fecal incontinence in the elderly patient. Am J Med 115 (2003) 217-227
72. Fox J.C., Fletcher J.G., Zinsmeister A.R., et al. Effect of aging on anorectal and pelvic floor functions in females. Dis Colon Rectum 49 (2006) 1726-1735
73. Goldschmiedt M., Barnet C.C., Schwarz B.E., et al. Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology 102 (1992) 2181-2182
74. Kekki M., Samloff I.M., Sipponen P., et al. Increase of serum pepsinogen I with age in females with normal gastric mucosa but not in males, possibly due to increase in acid-pepsin secreting area. Scan J Gastroenterol Suppl 186 (1991) 62-64
75. Goto H., Sugiyama S., Ohara A., et al. Age-associated decreases in prostaglandin contents in human gastric mucosa. Biochem Biophys Res Commun 186 (1992) 1443-1448
76. Pirlich M., Norman K., Lochs H., et al. Role of intestinal function in cachexia. Curr Opin Clin Nutr Metab Care 9 (2006) 603-606
77. Hopkins M.J., Sharp R., and MacFarlane G.T. Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 48 (2001) 198-205
78. Hopkins M.J., and MacFarlane G.T. Evaluation of 16s rRNA and cellular fatty acid profiles as markers of human intestinal bacterial growth in the chemostat. J Appl Microbiol 89 (2000) 668-677
79. Gorbach S.L., Nahas L., Lerner P.I., et al. Studies of intestinal microflora. I. Effects of diet, age, and periodic sampling on numbers of fecal microorganisms in man. Gastroenterology 53 (1967) 845-855
80. Morley J.E. An overview of diabetes mellitus in older persons. Clin Geriatr Med 15 (1999) 211-224
81. Edwards B.J., Perry H.M., Kaiser F.E., et al. Age-related changes in amylin secretion. Mech Ageing Dev 86 (1996) 39-51
82. Edwards B.J., and Morley J.E. Amylin. Life Sci 51 (1992) 1899-1912
83. Morley J.E., Flood J.F., Farr S.A., et al. Effects of amylin on appetite regulation and memory. Can J Physiol Pharmacol 73 (1995) 1042-1046
84. Diano S., Farr S.A., Benoit S.C., et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9 (2006) 381-388
85. Flood J.F., and Morley J.E. Cholecystokinin receptors mediate enhanced memory retention produced by feeding and gastrointestinal peptides. Peptides 10 (1989) 809-813
86. Flood J.F., and Morley J.E. Effects of bombesin and gastrin-releasing peptide on memory processing. Brain Res 460 (1988) 314-322
87. Morley J.E. Food for thought. Am J Clin Nutr 74 (2001) 567-568
88. Laugier R., Bernard J.P., Berthezene P., et al. Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion 50 (1991) 202-211
89. Matsumoto S., Harada H., Tanaka J., et al. Aging and exocrine pancreatic function. Nippon Ronen Igakkai Zasshi 26 (1989) 146-152
90. Ishibashi T., Matsumoto S., Harada H., et al. Aging and exocrine pancreatic function evaluated by the recently standardized secretin test. Nippon Ronen Igakkai Zasshi 28 (1991) 599-605
91. Detlefsen S., Sipos B., Feyerabend B., et al. Pancreatic fibrosis associated with age and ductal papillary hyperplasia. Virchows Arch 447 (2005) 800-805
92. Glaser J., and Stienecker K. Pancreas and aging: a study using ultrasonography. Gerontology 46 (2000) 93-96
93. Schmucker D.L. Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Aging 18 (2001) 837-851
94. Wakabayashi H., Nishiyama Y., Ushiyama T., et al. Evaluation of the effect of age on functioning hepatocyte mass and liver blood flow using liver scintigraphy in preoperative estimations for surgical patients: comparison with CT volumetry. J Surg Res 106 (2002) 246-253
95. Regev A., and Schiff E.R. Liver disease in the elderly. Gastroenterol Clin North Am 30 (2001) 547-563
96. Leclercq I., Horsmans Y., De Bruyere M., et al. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors. Acta Gastroenterol Belg 62 (1999) 16-20
97. Elinav E., Ben-Dov I.Z., Ackerman E., et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol 100 (2005) 2201-2204
98. Woodhouse K. Drugs and the liver. Part III: ageing of the liver and the metabolism of drugs. Biopharm Drug Dispos 13 (1992) 311-320
99. Ishizawa Y., Yasui-Furukori N., Takahata T., et al. The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clin Pharmacokinet 44 (2005) 1179-1189
100. Zapletal C.H., Faust D., Sullstein C., et al. Does the liver ever age? Results of liver transplantation with donors above 80 years of age. Transplant Proc 37 (2005) 1182-1185
101. Bachar G.N., Cohen M., Belenky A., et al. Effect of aging on the adult extrahepatic bile duct: a sonographic study. J Ultrasound Med 22 (2003) 879-882