Sample size needed to detect gene-gene interactions using linkage analysis

Annals of Human Genetics

Volumn 71, Issue 6, 2007, Pages 828-842

  Wang, Shuang ^a   Zhao, Hongyu ^b  

^a Mailman School of Public Health   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; AUTOSOMAL RECESSIVE INHERITANCE; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; FAMILY STUDY; GENE FREQUENCY; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC EPISTASIS; GENETIC HETEROGENEITY; GENETIC RECOMBINATION; GENETIC SUSCEPTIBILITY; INTERMETHOD COMPARISON; LINKAGE ANALYSIS; LOGISTIC REGRESSION ANALYSIS; MATHEMATICAL COMPUTING; PENETRANCE; POPULATION GENETICS; PRIORITY JOURNAL; SAMPLE SIZE; SIBLING; STATISTICAL SIGNIFICANCE;

FEMALE; GENETIC LINKAGE; HUMANS; LIKELIHOOD FUNCTIONS; LOGISTIC MODELS; MALE; MODELS, GENETIC; PENETRANCE; PHENOTYPE; SAMPLE SIZE; SIBLINGS;

EID: 34948886691     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2007.00367.x     Document Type: Article

References (30)

1. Boehnke, M. & Langefeld C. D. (1998) Genetic association mapping based on discordant sib pairs: The discordant-alleles test. Am J Hum Genet 62, 950-961
2. Carlborg, O. & Andersson, L. (2002) Use of randomization testing to detect multiple epistatic QTLs. Genet Res 79, 175-184.
3. Chatterjee, N., Kalaylioglu, Z., Moslehi, R., Peters, U. & Wacholder, S. (2006) Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. Am J Hum Genet 79, 1002-1016.
4. Cordell, H. J. (2002) Epistasis: What it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11 (20), 2463-2468.
5. Cordell, H. J., Wedig, G. C., Jacobs, K. B. & Elston, R. C. (2000) Multilocus linkage tests based on affected relative pairds. Am J Hum Genet 66, 1273-1286.
6. Cordell, H. J., Todd, J. A., Bennett, S. T., Kawaguchi, Y & Farrall, M. (1995) Two-locus maximum lod score analysis of a multifactorial trait: Joint consideration of IDDM2 and IDDM4 with IDDM1 in type I diabetes. Am J Hum Genet 57, 920-934.
7. Corderll, H. J. (2003) Affected-sib-pair data can be used to distinguish two-locus heterogeneity from two-locus epistasis. Am J Hum Genet 73, 1468-1471.
8. Cox, N. J., Frigge, M., Nicolae, D. L., Concannon, P., Hanis, C. L., Bell, G. I. & Kong, A. (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nature Genet 21, 213-215.
9. Curtis, D. (1997) Use of siblings as controls in case-control association studies. Ann Hum Genet 61: 319-333.
10. Dong, C. H., Wang, S., Li, W. D., Li, D., Zhao, H. Y. & Price, A. R. (2003) Interacting genetic loci on chromosome 20 and 10 influence extreme human obesity. Am J Hum Genet 72, 115-124.
11. Elston, R. C., Song, D. H. & Iyengar, S. K. (2005) Mathematical assumptions versus biological reality: Myths in affected sib pair linkage analysis. Amer J Hum Genet 76, 152-156.
12. Farral, M. (2003) Reports of the death of the epistasis model are greatly exaggerated. Am J Hum Genet 73, 1467-1468.
13. Gauderman, W. J. (2002) Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 155, 478-484.
14. Gauderman, W. J. & Siegmund, K. D. (2000) Gene-environment interaction and affected sib pair linkage analysis. Hum Hered 52, 34-46.
15. Guo, S. W. (2000) Gene-environment interactions and the affected-sib-pair designs. Hum Hered 50, 271-285.
16. Hallgrimsdottir, I. B. (2004) Affected Sib-Pair Two-Locus Linkage Analysis. Presentation at Genetics of Complex Disease workshop, MSRI, Berkeley.
17. Haseman J. K. & Elston R. C. (1972) The investigation of linkage between a quantitative trait and a marker locus. Behavior Genet 2, 3-19.
18. Holmans, P. (2002) Detecting gene-gene interactions using affected sib pair analysis with covariates. Hum Hered 53, 92-102.
19. Kruglyak, L., Daly, M. J., Reeve-Daly, M. P. & Lander, E. S. (1996) Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58, 1347-1363.
20. Li, W. T. & Reich, J. (2000) A complete enumeration and classification of two-locus disease models. Hum Hered 50, 334-349.
21. MacLean, C. J., Sham, P. C. & Kendler, K. S. (1993) Joint linkage of multiple loci for a complex disorder. Am J Hum Genet 53, 353-366.
22. Neuman, R. J. & Rice, J. P. (1992) Two-locus models of disease. Genet Epidemiol 9, 347-365.
23. Risch, N. (1990) Linkage strategies for genetically complex traits. I. multilocus models. Am J Hum Genet 46, 222-228.
24. Risch, N. (1990) Linkage strategies for genetically complex traits. II. The power of affected sib pairs. Am J Hum Genet 46, 229-241.
25. Risch, N. & Merikangas, K. (1996) The future of genetic studies of complex diseases. Science 273, 1516-1517.
26. Schaid, D. J. (1999) Case-parents design for gene-environment interaction. Genet Epidemiol 6, 261-273.
27. Vieland, V. J. & Huang, J. (2003) Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data. Am J Hum Genet 73, 223-232.
28. Sha, Q. Y., Zhu, X. F., Zou, Y., Cooper, R., Zhang, S. L. (2006) A combinatorial searching method for detecting a set of interacting loci associated with complex traits. Ann Hum Genet 70, 677-692.
29. Wang, S. & Zhao, H.Y. (2003) Sample size needed to detect gene-gene interactions using association designs. Am J Epidemiol 158, 899-914.
30. Zhao, J. Y., Jin, L. & Xiong, M. M. (2006) Test for interaction between two unlinked loci. Am J Hum Genet 79, 831-845.