A short and efficient synthesis of 3-[2,2,2-trifluoroethyl]hexahydro-2H-1, 4-diazepin-2-one

Synthesis

Volumn , Issue 18, 2007, Pages 2779-2781

  Balsells, Jaume ^a   Waters, Marjorie ^a   Hansen, Karl ^a   Kieczykowski, Gerard R ^a   Song, Zhiguo J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Alkylation; Fluorine; Hydrogenation; Lactam; Michael addition

Indexed keywords

MICHAEL ADDITION;

ADDITION REACTIONS; ALKYLATION; DRUG PRODUCTS; FLUORINE; HYDROGENATION; SYNTHESIS (CHEMICAL);

KETONES;

3 [2,2,2 TRIFLUOROETHYL]HEXAHYDRO 2H 1,4 DIAZEPIN 2 ONE; DIAZEPINE DERIVATIVE; FLUORINE; LACTAM; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CONJUGATION; CRYSTALLIZATION; FLUORINATION; HYDROGENATION; MICHAEL ADDITION; SUBSTITUTION REACTION; SYNTHESIS;

EID: 34948859428     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-983876     Document Type: Article

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