An enantioselective formal total synthesis of (-)-TAN1251A

Synlett

Volumn , Issue 8, 2004, Pages 1443-1445

  Auty, James M A ^a   Churcher, Ian ^b   Hayes, Christopher J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Alkaloid; Asymmetric synthesis; Carbene insertion; Spiro compounds; Total synthesis

Indexed keywords

MUSCARINIC RECEPTOR BLOCKING AGENT; TAN 1251A; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; OXIDATION; POLYMERIZATION; STANDARDIZATION;

EID: 3142733592     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-829092     Document Type: Article

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21. We found that the final reduction of 15 was capricious and that (-)-TAN1251A(1) was quite difficult to isolate in pure form. These difficulties have not previously been reported for this compound, but significant losses of material were incurred upon repeated chromatography.