Modeling of DNA fragmentation induced in human fibroblasts by 56 Fe ions

Advances in Space Research

Volumn 40, Issue 9, 2007, Pages 1401-1407

  Alloni, D ^a   Ballarini, F ^a   Belli, M ^b   Campa, A ^b   Esposito, G ^b   Friedland, W ^c   Liotta, M ^d,e   Ottolenghi, A ^a   Paretzke, H G ^c  

^a UNIVERSITY OF PAVIA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF MILAN   (Italy)

^e INFN SEZIONE DI PAVIA   (Italy)

Author keywords

DNA fragmentation; Iron ions; Monte Carlo simulations; Nonrandom DSB distributions; RBE for DSB yield

Indexed keywords

FIBROBLASTS; IONS; IRON; MAMMALS; MATHEMATICAL MODELS; MONTE CARLO METHODS;

DNA FRAGMENTATION; IRON IONS; NONRANDOM DSB DISTRIBUTIONS;

DNA SEQUENCES;

EID: 34948818285     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2007.05.078     Document Type: Article

References (26)

1. Antonelli F., Belli M., Campa A., et al. DNA fragmentation induced by Fe ions in human cells: shielding influence on spatially correlated damage. Adv. Space Res. 34 (2004) 1353-1357
2. 56 Fe ions of differing energies. Radiat. Res. 78 (2006) 713-720
3. Belli M., Cherubini R., Dalla Vecchia M., et al. DNA fragmentation in V79 cells irradiated with light ions as measured by PFGE I. Experimental results. Int. J. Radiat. Biol. 78 (2002) 475-482
4. Campa A., Ballarini F., Belli M., et al. DNA DSB induced in human cells by charged particles and gamma rays: experimental results and theoretical approaches. Int. J. Radiat. Biol. 81 (2005) 841-854
5. Campa A., Esposito G., Belli M., et al. DNA fragmentation in V79 cells irradiated with light ions as measured by pulsed-field gel electrophoresis. II. Simulation with a generalized broken stick model. Int. J. Radiat. Biol. 80 (2004) 229-238
6. -1 . Radiat. Res. 151 (1999) 540-549
7. Friedland W., Jacob P., Paretzke H.G., et al. Simulation of light ion induced DNA damage patterns. Radiat. Prot. Dosim. 122 (2006) 116-120
8. Friedland W., Jacob P., Bernhardt P., et al. Simulation of DNA damage after proton irradiation. Radiat. Res. 159 (2003) 401-410
9. Friedland W., Jacob P., Paretzke H.G., and Stork T. Monte Carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higher-order DNA models. Radiat. Res. 150 (1998) 170-182
10. Goodhead D.T. Initial events in the cellular effects of ionising radiation: clustered damage in DNA. Int. J. Radiat. Biol. 65 (1994) 7-17
11. Höglund E., Blomquist E., Carlsson J., and Stenerlöw B. DNA damage induced by radiation of different linear energy transfer: initial fragmentation. Int. J. Radiat. Biol. 76 (2000) 539-547
12. Holley W.R., and Chatterjee A. Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling. Radiat. Res. 145 (1996) 188-199
13. Löbrich M., Cooper P.K., and Rydberg B. Non-random distribution of DNA double-strand breaks induced by particle irradiation. Int. J. Radiat. Biol. 70 (1996) 493-503
14. Newman H.C., Prise K.M., Folkard M., and Michael B.D. DNA double-strand break distributions in X-ray and α-particle irradiated V79 cells: evidence for non-random breakage. Int. J. Radiat. Biol. 71 (1997) 347-363
15. Pinto M., Prise K.M., and Michael B.D. A Monte Carlo model of DNA double-strand break clustering and rejoining kinetics for the analysis of pulsed-field gel electrophoresis data. Radiat. Res. 162 (2004) 453-463
16. Ponomarev A.L., Brenner D., Hlatky L.R., and Sachs R.K. A polymer, random-walk model for the size distribution of large DNA fragments after high linear energy transfer radiation. Radiat. Environ. Biophys. 39 (2000) 111-120
17. Ponomarev A.L., Belli M., Hahnfeldt P.J., Hlatky L., Sachs R.K., and Cucinotta F.A. A robust procedure for removing background damage in assays of radiation-induced DNA fragment distributions. Radiat. Res. 166 (2006) 908-916
18. Ponomarev A.L., and Cucinotta F.A. Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes. Int. J. Radiat. Biol. 82 (2006) 293-305
19. Ponomarev A.L., and Sachs R.K. Polymer chromosome models and Monte Carlo simulations of radiation breaking DNA. Bioinformatics 15 (1999) 957-964
20. Ponomarev A.L., and Sachs R.K. Radiation breakage of DNA: a model based on random-walk chromatin structure. J. Math. Biol. 43 (2001) 356-376
21. Rydberg B. Radiation-induced heat-labile sites that convert into DNA double-strand breaks. Radiat. Res. 153 (2000) 805-812
22. Rydberg B. Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. II. Experimental detection. Radiat. Res. 145 (1996) 200-209
23. Rydberg B., Holley W.R., Mian I.S., and Chatterjee A. Chromatin conformation in living cells: support for a zig-zag model of the 30 nanometer chromatin fiber. J. Mol. Biol. 284 (1998) 71-84
24. Sachs R.K., Brenner D.J., Hahnfeldt P.J., and Hlatky L.R. A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes. Int. J. Radiat. Biol. 74 (1998) 185-206
25. Sachs R.K., Ponomarev A.L., Hahnfeldt P.J., and Hlatky L.R. Locations of radiation-produced DNA double strand breaks along chromosomes: a stochastic cluster process formalism. Math. Biosc. 159 (1999) 165-187
26. Stenerlöw B., Karlsson K.H., Cooper B., and Rydberg B. Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: results for cells deficient in nonhomologous end joining. Radiat. Res. 159 (2003) 502-510