The role of external signal regulated kinase and transforming growth factor β1 in asthma airway remodeling and regulation of glucocorticoids

National Medical Journal of China

Volumn 87, Issue 25, 2007, Pages 1767-1772

  Guan, Xiao Jun ^a   Zhang, Wei Xi ^a   Li, Chang Chong ^a   Zheng, Yang Ming ^a   Lin, Li ^a   Ye, Le Ping ^a   Chen, Xiao Fang ^a   Luo, Yun Chun ^a   Cai, Xiao Hong ^a   Dong, Lin ^a   Zhang, Hai Lin ^a   Zhou, Xiao Cong ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Airway remodeling; Asthma; Mitogen activated protein kinases; Platelet derived growth factor; Transforming growth factor 1

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BUDESONIDE; DEXAMETHASONE; GLUCOCORTICOID; MITOGEN ACTIVATED PROTEIN KINASE; OVALBUMIN; PLATELET DERIVED GROWTH FACTOR BB; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BLOOD SAMPLING; BRONCHUS; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMORAL ARTERY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; NONHUMAN; OPTICAL DENSITY; PATHOPHYSIOLOGY; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE; SUPERNATANT; WESTERN BLOTTING;

ANIMALS; ASTHMA; BRONCHI; BUTADIENES; DEXAMETHASONE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOCORTICOIDS; INJECTIONS, INTRAPERITONEAL; LUNG; NITRILES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 34948817789     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Palmans E, Kips JC, Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med, 2000, 161(2 Pt 1):627-635.
2. Chinese source.
3. Xiong W, Xu Y, Zhang Z, et al. Nuclear factor-kappa B in signal conduction of protein kinase C in T lymphocytes from an asthmatic guinea pig model. Chin Med J (Engl), 2002, 115:685-689.
4. Bai A, Eidelman DH, Hogg JC, et al. Proposed nomenclature for quantifying subdivisions of the bronchial wall. J Appl Physiol, 1994, 77:1011-1014.
5. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science, 2002, 298:1911-1912.
6. Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev, 2001, 22:153-183.
7. Masuda T, Tanaka H, Komai M, et al. Mast cells play a partial role in allergen-induced subepithelial fibrosis in a routine model of allergic asthma. Clin Exp Allergy, 2003, 33:705-713.
8. Corbel M, Caulet-Maugendre S, Germain N, et al. Enhancement of gelatinase activity during development of subepithelial fibrosis in a murine model of asthma. Clin Exp Allergy, 2003, 33:696-704.
9. Duan W, Chan JH, Wong CH, et al. Anti-inflammatory effects of mitogan-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol, 2004, 172:7053-7059.
10. Kips JC, Pauwels RA. Airway wall remodelling: does it occur and what does it mean? Clin Exp Allergy, 1999, 29:1457-1466.
11. Helgate ST, Lackie PM, Davies DE, et al. The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma. Clin Exp Allergy, 1999, 29(Suppl)2:90-95.
12. Holgate ST, Davies DE, Lackie PM, et al. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol, 2000, 105(2 Pt 1):193-204.
13. Kumar RK, Herbert C, Foster PS. Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis. Clin Exp Allergy, 2004, 34: 567-575.
14. Richter A, Puddicombe SM, Lordan JL, et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol, 2001, 25: 385-391.
15. Lee CG, Homer RJ, Zhu Z, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med, 2001, 194:809-821.
16. Pelaia G, Cuda G, Vatrella A, et al. Mitogen-activated protein kinases and asthma. J Cell Physiol, 2005, 202:642-653.