T cell allorecognition and MHC restriction-A case of Jekyll and Hyde?

Molecular Immunology

Volumn 45, Issue 3, 2008, Pages 583-598

  Archbold, Julia K ^a   Ely, Lauren K ^a   Kjer Nielsen, Lars ^b   Burrows, Scott R ^c   Rossjohn, Jamie ^a   McCluskey, James ^b   Macdonald, Whitney A ^a  

^a Department of Physiology School of Biomedical Sciences   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Major histocompatibility complex; T cell allorecognition; T cell receptor

Indexed keywords

ALLOIMMUNITY; ANTIBODY AFFINITY; CELLULAR IMMUNITY; CRYSTAL STRUCTURE; CYTOTOXIC T LYMPHOCYTE; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; LYMPHOID CELL; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THYMOCYTE; TISSUE TRANSPLANTATION;

ANIMALS; ANTIGEN PRESENTATION; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS; HUMANS; ISOANTIGENS; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC; TISSUE TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY;

EID: 34848926194     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.05.018     Document Type: Review

References (156)

1. Ajitkumar P., Geier S.S., Kesari K.V., Borriello F., Nakagawa M., Bluestone J.A., Saper M.A., Wiley D.C., and Nathenson S.G. Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell 54 (1988) 47-56
2. Aldrich C.J., DeCloux A., Woods A.S., Cotter R.J., Soloski M.J., and Forman J. Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Cell 79 (1994) 649-658
3. Ashton-Rickardt P.G., Bandeira A., Delaney J.R., Van Kaer L., Pircher H.P., Zinkernagel R.M., and Tonegawa S. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76 (1994) 651-663
4. Auchincloss H., and Sachs D.H. Transplantation and graft rejection. In: Paul W.E. (Ed). Fundamental Immunology (1993), Raven Press Ltd, New York 1099-1141
5. Barnes D.W., Corp M.J., Loutit J.F., and Neal F.E. Treatment of murine leukaemia with X rays and homologous bone marrow; preliminary communication. Br. Med. J. 32 (1956) 626-627
6. Barouch D., Friede T., Stevanovic S., Tussey L., Smith K., Rowland-Jones S., Braud V., McMichael A., and Rammensee H.G. HLA-A2 subtypes are functionally distinct in peptide binding and presentation. J. Exp. Med. 182 (1995) 1847-1856
7. Beatty P.G., Clift R.A., Mickelson E.M., Nisperos B.B., Flournoy N., Martin P.J., Sanders J.E., Stewart P., Buckner C.D., Storb R., et al. Marrow transplantation from related donors other than HLA-identical siblings. N. Engl. J. Med. 313 (1985) 765-771
8. Bevan M.J. Hi determinants density may explain the phenomenon of alloreactivity. Immunol. Today 5 (1984) 128-130
9. Bevan M.J. In thymic selection. peptide diversity gives and takes away. Immunity 7 (1997) 175-178
10. Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., and Wiley D.C. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329 (1987) 512-518
11. Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., and Wiley D.C. Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329 (1987) 506-512
12. Bluestone J.A., Kaliyaperumal A., Jameson S., Miller S., and Dick II R. Peptide-induced changes in class I heavy chains alter allorecognition. J. Immunol. 151 (1993) 3943-3953
13. Brown J.H., Jardetzky T.S., Gorga J.C., Stern L.J., Urban R.G., Strominger J.L., and Wiley D.C. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364 (1993) 33-39
14. Burrows S.R., Burrows J.M., and Moss D.J. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. J. Exp. Med. 179 (1994) 1155-1161
15. Burrows S.R., Silins S.L., Moss D.J., Khanna R., Misko I.S., and Argaet V.P. T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J. Exp. Med. 182 (1995) 1703-1715
16. Burrows S.R., Silins S.L., Cross S.M., Peh C.A., Rischmueller M., Burrows J.M., Elliott S.L., and McCluskey J. Human leukocyte antigen phenotype imposes complex constraints on the antigen-specific cytotoxic T lymphocyte repertoire. Eur. J. Immunol. 27 (1997) 178-182
17. Burrows S.R., Silins S.L., Khanna R., Burrows J.M., Rischmueller M., McCluskey J., and Moss D.J. Cross-reactive memory T cells for Epstein-Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex-bound peptide by T cells and its role in alloreactivity. Eur. J. Immunol. 27 (1997) 1726-1736
18. Chattopadhyay S., Theobald M., Biggs J., and Sherman L.A. Conformational differences in major histocompatibility complex-peptide complexes can result in alloreactivity. J. Exp. Med. 179 (1994) 213-219
19. Clift R.A., Hansen J.A., Thomas E.D., Buckner C.D., Sanders J.E., Mickelson E.M., Storb R., Johnson F.L., Singer J.W., and Goodell B.W. Marrow transplantation from donors other than HLA-identical siblings. Transplantation 28 (1979) 235-242
20. Cook J.R., Wormstall E.M., Hornell T., Russell J., Connolly J.M., and Hansen T.H. Quantitation of the cell surface level of Ld resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo. Immunity 7 (1997) 233-241
21. Crawford F., Huseby E., White J., Marrack P., and Kappler J.W. Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol. 2 (2004) E90
22. Davis M.M., and Bjorkman P.J. T-cell antigen receptor genes and T-cell recognition. Nature 334 (1988) 395-402
23. Degano M., Garcia K.C., Apostolopoulos V., Rudolph M.G., Teyton L., and Wilson I.A. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity 12 (2000) 251-261
24. Delaney J.R., Sykulev Y., Eisen H.N., and Tonegawa S. Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 5235-5240
25. den Haan J.M., Meadows L.M., Wang W., Pool J., Blokland E., Bishop T.L., Reinhardus C., Shabanowitz J., Offringa R., Hunt D.F., Engelhard V.H., and Goulmy E. The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science 279 (1998) 1054-1057
26. Ding Y.H., Baker B.M., Garboczi D.N., Biddison W.E., and Wiley D.C. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity 11 (1999) 45-56
27. Dolstra H., Fredrix H., Maas F., Coulie P.G., Brasseur F., Mensink E., Adema G.J., de Witte T.M., Figdor C.G., and van de Wiel-van Kemenade E. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia. J. Exp. Med. 189 (1999) 301-308
28. Elliott T.J., and Eisen H.N. Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 5213-5217
29. Ely L.K., Green K.J., Beddoe T., Clements C.S., Miles J.J., Bottomley S.P., Zernich D., Kjer-Nielsen L., Purcell A.W., McCluskey J., Rossjohn J., and Burrows S.R. Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection. J. Immunol. 174 (2005) 5593-5601
30. Engelhard V.H. Structure of peptides associated with class I and class II MHC molecules. Annu. Rev. Immunol. 12 (1994) 181-207
31. Fangmann J., Dalchau R., and Fabre J.W. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J. Exp. Med. 175 (1992) 1521-1529
32. Fangmann J., Dalchau R., Sawyer G.J., Priestley C.A., and Fabre J.W. T cell recognition of donor major histocompatibility complex class I peptides during allograft rejection. Eur. J. Immunol. 22 (1992) 1525-1530
33. Felix N.J., Suri A., Walters J.J., Horvath S., Gross M.L., and Allen P.M. I-Ep-bound self-peptides: identification, characterization, and role in alloreactivity. J. Immunol. 176 (2006) 1062-1071
34. Fink P.J., and Bevan M.J. H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med. 148 (1978) 766-775
35. Fleischhauer K., Kernan N.A., O'Reilly R.J., Dupont B., and Yang S.Y. Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44. N. Engl. J. Med. 323 (1990) 1818-1822
36. Fleischhauer K., Kernan N.A., Dupont B., and Yang S.Y. The two major subtypes of HLA-B44 differ for a single amino acid in codon 156. Tissue Antigens 37 (1991) 133-137
37. Fleischhauer K., Avila D., Vilbois F., Traversari C., Bordignon C., and Wallny H.J. Characterization of natural peptide ligands for HLA-B*4402 and -B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA-B44 heavy chain. Tissue Antigens 44 (1994) 311-317
38. Garboczi D.N., Ghosh P., Utz U., Fan Q.R., Biddison W.E., and Wiley D.C. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384 (1996) 134-141
39. Garcia K.C., Degano M., Stanfield R.L., Brunmark A., Jackson M.R., Peterson P.A., Teyton L., and Wilson I.A. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274 (1996) 209-219
40. Garcia K.C., Degano M., Speir J.A., and Wilson I.A. Emerging principles for T cell receptor recognition of antigen in cellular immunity. Rev. Immunogenet. 1 (1999) 75-90
41. Garcia K.C., Teyton L., and Wilson I.A. Structural basis of T cell recognition. Annu. Rev. Immunol. 17 (1999) 369-397
42. Gould D.S., and Auchincloss Jr. H. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol. Today 20 (1999) 77-82
43. Goulmy E. Human minor histocompatibility antigens. Curr. Opin. Immunol. 8 (1996) 75-81
44. Goulmy E., Termijtelen A., Bradley B.A., and van Rood J.J. Alloimmunity to human H-Y. Lancet 2 (1976) 1206
45. Goulmy E., Termijtelen A., Bradley B.A., and van Rood J.J. Y-antigen killing by T cells of women is restricted by HLA. Nature 266 (1977) 544-545
46. Goulmy E., Gratama J.W., Blokland E., Zwaan F.E., and van Rood J.J. A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease. Nature 302 (1983) 159-161
47. Goulmy E., Schipper R., Pool J., Blokland E., Falkenburg J.H., Vossen J., Gratwohl A., Vogelsang G.B., van Houwelingen H.C., and van Rood J.J. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N. Engl. J. Med. 334 (1996) 281-285
48. Guo H.C., Jardetzky T.S., Garrett T.P., Lane W.S., Strominger J.L., and Wiley D.C. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature 360 (1992) 364-366
49. Hammer G.E., Gonzalez F., Champsaur M., Cado D., and Shastri N. The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat. Immunol. 7 (2006) 103-112
50. Harrison J.H., Merrill J.P., and Murray J.E. Renal homotransplantation in identical twins. Surg. Forum. 6 (1956) 432-436
51. Heath W.R., Kane K.P., Mescher M.F., and Sherman L.A. Alloreactive T cells discriminate among a diverse set of endogenous peptides. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 5101-5105
52. Henderson R.A., Michel H., Sakaguchi K., Shabanowitz J., Appella E., Hunt D.F., and Engelhard V.H. HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science 255 (1992) 1264-1266
53. Herman J., Jongeneel V., Kuznetsov D., and Coulie P.G. Differences in the recognition by CTL of peptides presented by the HLA- B*4402 and the HLA-B*4403 molecules which differ by a single amino acid. Tissue Antigens 53 (1999) 111-121
54. Housset D., and Malissen B. What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?. Trends Immunol. 24 (2003) 429-437
55. Hunt D.F., Henderson R.A., Shabanowitz J., Sakaguchi K., Michel H., Sevilir N., Cox A.L., Appella E., and Engelhard V.H. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255 (1992) 1261-1263
56. Jameson S.C., Hogquist K.A., and Bevan M.J. Positive selection of thymocytes. Annu. Rev. Immunol. 13 (1995) 93-126
57. Janeway Jr. C.A. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16 (1995) 223-225
58. Janeway Jr. C.A., Dianzani U., Portoles P., Rath S., Reich E.P., Rojo J., Yagi J., and Murphy D.B. Cross-linking and conformational change in T-cell receptors: role in activation and in repertoire selection. Cold Spring Harb. Symp. Quant. Biol. 54 Pt 2 (1989) 657-666
59. Karttunen J., and Shastri N. Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 3972-3976
60. Karttunen J., Sanderson S., and Shastri N. Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 6020-6024
61. Keever C.A., Leong N., Cunningham I., Copelan E.A., Avalos B.R., Klein J., Kapoor N., Adams P.W., Orosz C.G., Tutschka P.J., et al. HLA-B44-directed cytotoxic T cells associated with acute graft-versus- host disease following unrelated bone marrow transplantation. Bone Marrow Transplant. 14 (1994) 137-145
62. Kjer-Nielsen L., Clements C.S., Purcell A.W., Brooks A.G., Whisstock J.C., Burrows S.R., McCluskey J., and Rossjohn J. A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity 18 (2003) 53-64
63. Koelle D.M., Chen H.B., Gavin M.A., Wald A., Kwok W.W., and Corey L. CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells. J. Immunol. 166 (2001) 4049-4058
64. Koelle D.M., Chen H.B., McClurkan C.M., and Petersdorf E.W. Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles. Blood 99 (2002) 3844-3847
65. Lafferty K.J., Prowse S.J., Simeonovic C.J., and Warren H.S. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Annu. Rev. Immunol. 1 (1983) 143-173
66. Lechler R.I., Lombardi G., Batchelor J.R., Reinsmoen N., and Bach F.H. The molecular basis of alloreactivity. Immunol. Today 11 (1990) 83-88
67. Lindahl K.F., and Wilson D.B. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors. J. Exp. Med. 145 (1977) 508-522
68. Little A.M., and Parham P. Polymorphism and evolution of HLA class I and II genes and molecules. Rev. Immunogenet. 1 (1999) 105-123
69. Liu Z., Braunstein N.S., and Suciu-Foca N. T cell recognition of allopeptides in context of syngeneic MHC. J. Immunol. 148 (1992) 35-40
70. Luz J.G., Huang M., Garcia K.C., Rudolph M.G., Apostolopoulos V., Teyton L., and Wilson I.A. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J. Exp. Med. 195 (2002) 1175-1186
71. Luz J.G., Huang M., Garcia K.C., Rudolph M.G., Apostolopoulos V., Teyton L., and Wilson I.A. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing Vbeta interactions. J. Exp. Med. 195 (2002) 1175-1186
72. Macdonald W., Williams D.S., Clements C.S., Gorman J.J., Kjer-Nielsen L., Brooks A.G., McCluskey J., Rossjohn J., and Purcell A.W. Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex. FEBS Lett. 527 (2002) 27-32
73. Macdonald W.A., Purcell A.W., Mifsud N.A., Ely L.K., Williams D.S., Chang L., Gorman J.J., Clements C.S., Kjer-Nielsen L., Koelle D.M., Burrows S.R., Tait B.D., Holdsworth R., Brooks A.G., Lovrecz G.O., Lu L., Rossjohn J., and McCluskey J. A naturally selected dimorphism within the HLA-B44 supertype alters class i structure, peptide repertoire, and T cell recognition. J. Exp. Med. 198 (2003) 679-691
74. Madden D.R., Gorga J.C., Strominger J.L., and Wiley D.C. The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature 353 (1991) 321-325
75. Madden D.R., Gorga J.C., Strominger J.L., and Wiley D.C. The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell 70 (1992) 1035-1048
76. Malarkannan S., Afkarian M., and Shastri N. A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells. J. Exp. Med. 182 (1995) 1739-1750
77. Malarkannan S., Shih P.P., Eden P.A., Horng T., Zuberi A.R., Christianson G., Roopenian D., and Shastri N. The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161 (1998) 3501-3509
78. Malarkannan S., Horng T., Shih P.P., Schwab S., and Shastri N. Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. Immunity 10 (1999) 681-690
79. Malarkannan S., Horng T., Eden P., Gonzalez F., Shih P., Brouwenstijn N., Klinge H., Christianson G., Roopenian D., and Shastri N. Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens. Immunity 13 (2000) 333-344
80. Mandruzzato S., Stroobant V., Demotte N., and van der Bruggen P. A human CTL recognizes a caspase-8-derived peptide on autologous HLA-B*3503 molecules and two unrelated peptides on allogeneic HLA-B*3501 molecules. J. Immunol. 164 (2000) 4130-4134
81. Mannie M.D. A unified model for T cell antigen recognition and thymic selection of the T cell repertoire. J. Theor. Biol. 151 (1991) 169-192
82. Marsh S.G., Albert E.D., Bodmer W.F., Bontrop R.E., Dupont B., Erlich H.A., Geraghty D.E., Hansen J.A., Hurley C.K., Mach B., Mayr W.R., Parham P., Petersdorf E.W., Sasazuki T., Schreuder G.M., Strominger J.L., Svejgaard A., Terasaki P.I., and Trowsdale J. Nomenclature for factors of the HLA system, 2004. Tissue Anti. 65 (2005) 301-369
83. Maruya E., Saji H., Seki S., Fujii Y., Kato K., Kai S., Hiraoka A., Kawa K., Hoshi Y., Ito K., Yokoyama S., and Juji T. Evidence that CD31, CD49b, and CD62L are immunodominant minor histocompatibility antigens in HLA identical sibling bone marrow transplants. Blood 92 (1998) 2169-2176
84. Matzinger P., and Bevan M.J. Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?. Cell. Immunol. 29 (1977) 1-5
85. Matzinger P., Zamoyska R., and Waldmann H. Self tolerance is H-2-restricted. Nature 308 (1984) 738-741
86. Mendoza L.M., Paz P., Zuberi A., Christianson G., Roopenian D., and Shastri N. Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity 7 (1997) 461-472
87. Mendoza L.M., Villaflor G., Eden P., Roopenian D., and Shastri N. Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide. J. Immunol. 166 (2001) 4438-4445
88. Merrill J.P., Murray J.E., Harrison J.H., and Guild W.R. Successful homotransplantation of the human kidney between identical twins. J. Am. Med. Assoc. 160 (1956) 277-282
89. Miles J.J., Elhassen D., Borg N.A., Silins S.L., Tynan F.E., Burrows J.M., Purcell A.W., Kjer-Nielsen L., Rossjohn J., Burrows S.R., and McCluskey J. CTL recognition of a bulged viral peptide involves biased TCR selection. J. Immunol. 175 (2005) 3826-3834
90. Mommaas B., Kamp J., Drijfhout J.W., Beekman N., Ossendorp F., Van Veelen P., Den Haan J., Goulmy E., and Mutis T. Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus. J. Immunol. 169 (2002) 3131-3136
91. Nakayama S., Kawaguchi G., Karaki S., Nagao T., Uchida H., Kashiwase K., Akaza T., Nasuno T., and Takiguchi M. Effect of single amino acid substitution at residue 167 of HLA-B51 on binding of antibodies and recognition of T cells. Hum. Immunol. 39 (1994) 211-219
92. Obst R., Munz C., Stevanovic S., and Rammensee H.G. Allo- and self-restricted cytotoxic T lymphocytes against a peptide library: evidence for a functionally diverse allorestricted T cell repertoire. Eur. J. Immunol. 28 (1998) 2432-2443
93. Obst R., Netuschil N., Klopfer K., Stevanovic S., and Rammensee H.G. The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules. J. Exp. Med. 191 (2000) 805-812
94. OPTN/SRTR 2005 Annual R. (2005) 2005 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1994-2003. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD; United Network for Organ Sharing, Richmond, VA; University Renal Research and Education Association, Ann Arbor, MI.
95. Ostrov D.A., Roden M.M., Shi W., Palmieri E., Christianson G.J., Mendoza L., Villaflor G., Tilley D., Shastri N., Grey H., Almo S.C., Roopenian D., and Nathenson S.G. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J. Immunol. 168 (2002) 283-289
96. Paradela A., Garcia-Peydro M., Vazquez J., Rognan D., and Lopez de Castro J.A. The same natural ligand is involved in allorecognition of multiple HLA-B27 subtypes by a single t cell clone: role of peptide and the mhc molecule in alloreactivity. J. Immunol. 161 (1998) 5481-5490
97. Paradela A., Alvarez I., Garcia-Peydro M., Sesma L., Ramos M., Vazquez J., and Lopez De Castro J.A. Limited diversity of peptides related to an alloreactive T cell epitope in the HLA-B27-bound peptide repertoire results from restrictions at multiple steps along the processing-loading pathway. J. Immunol. 164 (2000) 329-337
98. Parham P., Lomen C.E., Lawlor D.A., Ways J.P., Holmes N., Coppin H.L., Salter R.D., Wan A.M., and Ennis P.D. Nature of polymorphism in HLA-A, -B, and -C molecules. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 4005-4009
99. Petersdorf E.W., Setoda T., Smith A.G., and Hansen J.A. Analysis of HLA-B*44 alleles encoded on extended HLA haplotypes by direct automated sequencing. Tissue Anti. 44 (1994) 211-216
100. Poindexter N.J., Naziruddin B., McCourt D.W., and Mohanakumar T. Isolation of a kidney-specific peptide recognized by alloreactive HLA-A3-restricted human CTL. J. Immunol. 154 (1995) 3880-3887
101. Probst-Kepper M., Stroobant V., Kridel R., Gaugler B., Landry C., Brasseur F., Cosyns J.P., Weynand B., Boon T., and Van Den Eynde B.J. An alternative open reading frame of the human macrophage colony-stimulating factor gene is independently translated and codes for an antigenic peptide of 14 amino acids recognized by tumor-infiltrating CD8 T lymphocytes. J. Exp. Med. 193 (2001) 1189-1198
102. Purbhoo M.A., Irvine D.J., Huppa J.B., and Davis M.M. T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5 (2004) 524-530
103. Rammensee H., and Bevan M.J. Evidence from in vitro studies that tolerance to self antigens is MHC-restricted. Nature 308 (1984) 741-744
104. Rammensee H.G., Falk K., and Rotzschke O. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11 (1993) 213-244
105. Reiser J.B., Darnault C., Guimezanes A., Gregoire C., Mosser T., Schmitt-Verhulst A.M., Fontecilla-Camps J.C., Malissen B., Housset D., and Mazza G. Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat. Immunol. 1 (2000) 291-297
106. Reiser J.B., Gregoire C., Darnault C., Mosser T., Guimezanes A., Schmitt-Verhulst A.M., Fontecilla-Camps J.C., Mazza G., Malissen B., and Housset D. A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity 16 (2002) 345-354
107. Reiser J.B., Darnault C., Gregoire C., Mosser T., Mazza G., Kearney A., van der Merwe P.A., Fontecilla-Camps J.C., Housset D., and Malissen B. CDR3 loop flexibility contributes to the degeneracy of TCR recognition. Nat. Immunol. 4 (2003) 241-247
108. Reits E.A., Vos J.C., Gromme M., and Neefjes J. The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature 404 (2000) 774-778
109. Robinson J., Waller M.J., Parham P., Groot N.d., Bontrop R., Kennedy L.J., Stoehr P., and Marsh S.G.E. IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucl. Acids Res. 31 (2003) 311-314
110. Rock K.L., Gramm C., Rothstein L., Clark K., Stein R., Dick L., Hwang D., and Goldberg A.L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78 (1994) 761-771
111. Rudolph M.G., and Wilson I.A. The specificity of TCR/pMHC interaction. Curr. Opin. Immunol. 14 (2002) 52-65
112. Rudolph M.G., Shen L.Q., Lamontagne S.A., Luz J.G., Delaney J.R., Ge Q., Cho B.K., Palliser D., McKinley C.A., Chen J., Wilson I.A., and Eisen H.N. A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects. J. Immunol. 172 (2004) 2994-3002
113. Rudolph M.G., Stanfield R.L., and Wilson I.A. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24 (2006) 419-466
114. Sahara H., and Shastri N. Second class minors: molecular identification of the autosomal H46 histocompatibility locus as a peptide presented by major histocompatibility complex class II molecules. J. Exp. Med. 197 (2003) 375-385
115. Sanderson S., and Shastri N. LacZ inducible, antigen/MHC-specific T cell hybrids. Int. Immunol. 6 (1994) 369-376
116. Schwab S.R., Li K.C., Kang C., and Shastri N. Constitutive display of cryptic translation products by MHC class I molecules. Science 301 (2003) 1367-1371
117. Sebzda E., Wallace V.A., Mayer J., Yeung R.S., Mak T.W., and Ohashi P.S. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263 (1994) 1615-1618
118. Sebzda E., Mariathasan S., Ohteki T., Jones R., Bachmann M.F., and Ohashi P.S. Selection of the T cell repertoire. Annu. Rev. Immunol. 17 (1999) 829-874
119. Sette A., and Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 50 (1999) 201-212
120. Sha W.C., Nelson C.A., Newberry R.D., Kranz D.M., Russell J.H., and Loh D.Y. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336 (1988) 73-76
121. Sha W.C., Nelson C.A., Newberry R.D., Kranz D.M., Russell J.H., and Loh D.Y. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335 (1988) 271-274
122. Sha W.C., Nelson C.A., Newberry R.D., Pullen J.K., Pease L.R., Russell J.H., and Loh D.Y. Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding. Proc. Natl. Acad. Sci. USA 87 (1990) 6186-6190
123. Shastri N., Schwab S., and Serwold T. Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules. Annu. Rev. Immunol. 20 (2002) 463-493
124. Sherman L.A. Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes. J. Exp. Med. 155 (1982) 380-389
125. Simonsen M. The impact on the developing embryo and newborn animal of adult homologous cells. Acta. Pathol. Microbiol. Scand. 40 (1957) 480-500
126. Smith K.D., Epperson D.F., and Lutz C.T. Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation. Immunogenetics 43 (1996) 27-37
127. Smith P.A., Brunmark A., Jackson M.R., and Potter T.A. Peptide-independent recognition by alloreactive cytotoxic T lymphocytes (CTL). J. Exp. Med. 185 (1997) 1023-1033
128. Speir J.A., Garcia K.C., Brunmark A., Degano M., Peterson P.A., Teyton L., and Wilson I.A. Structual basis of 2C TCR allorecognition of H-2Ld peptide complexes. Immunity 8 (1998) 553-562
129. Starr T.K., Jameson S.C., and Hogquist K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21 (2003) 139-176
130. Steinle A., Reinhardt C., Nossner E., Uchanska-Ziegler B., Ziegler A., and Schendel D.J. Microheterogeneity in HLA-B35 alleles influences peptide-dependent allorecognition by cytotoxic T cells but not binding of a peptide-restricted monoclonal antibody. Hum. Immunol. 38 (1993) 261-269
131. Stern L.J., Brown J.H., Jardetzky T.S., Gorga J.C., Urban R.G., Strominger J.L., and Wiley D.C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368 (1994) 215-221
132. Stewart-Jones G.B., McMichael A.J., Bell J.I., Stuart D.I., and Jones E.Y. A structural basis for immunodominant human T cell receptor recognition. Nat. Immunol. 4 (2003) 657-663
133. Strominger J.L., Humphreys R.E., McCune J.M., Parham P., Robb R., Springer T., and Terhorst C. The immunoglobulin-like structure of human histocompatibility antigens. Fed. Proc. 35 (1976) 1177-1182
134. Suchin E.J., Langmuir P.B., Palmer E., Sayegh M.H., Wells A.D., and Turka L.A. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J. Immunol. 166 (2001) 973-981
135. Sykulev Y., Brunmark A., Tsomides T.J., Kageyama S., Jackson M., Peterson P.A., and Eisen H.N. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. PNAS 91 (1994) 11487-11491
136. Terasaki P.I. Thirty-Five Recollections (1990), UCLA Tissue Typing Laboratory, Los Angeles p. 704
137. Thomas E., Storb R., Clift R.A., Fefer A., Johnson F.L., Neiman P.E., Lerner K.G., Glucksberg H., and Buckner C.D. Bone-marrow transplantation (first of two parts). N. Engl. J. Med. 292 (1975) 832-843
138. Thomas E.D., Storb R., Clift R.A., Fefer A., Johnson L., Neiman P.E., Lerner K.G., Glucksberg H., and Buckner C.D. Bone-marrow transplantation (second of two parts). N. Engl. J. Med. 292 (1975) 895-902
139. Tiercy J.M., Jeannet M., and Roosnek E. HLA-B44-restricted minor antigen. Transplantation 60 (1995) 113-114
140. Tynan F.E., Borg N.A., Miles J.J., Beddoe T., El-Hassen D., Silins S.L., van Zuylen W.J., Purcell A.W., Kjer-Nielsen L., McCluskey J., Burrows S.R., and Rossjohn J. High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance. J. Biol. Chem. 280 (2005) 23900-23909
141. Tynan F.E., Burrows S.R., Buckle A.M., Clements C.S., Borg N.A., Miles J.J., Beddoe T., Whisstock J.C., Wilce M.C., Silins S.L., Burrows J.M., Kjer-Nielsen L., Kostenko L., Purcell A.W., McCluskey J., and Rossjohn J. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat. Immunol. 6 (2005) 1114-1122
142. Tynan F.E., Elhassen D., Purcell A.W., Burrows J.M., Borg N.A., Miles J.J., Williamson N.A., Green K.J., Tellam J., Kjer-Nielsen L., McCluskey J., Rossjohn J., and Burrows S.R. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. J. Exp. Med. 202 (2005) 1249-1260
143. Udaka K., Tsomides T.J., and Eisen H.N. A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69 (1992) 989-998
144. Udaka K., Tsomides T.J., Walden P., Fukusen N., and Eisen H.N. A ubiquitous protein is the source of naturally occuring peptides that are recognized by a CD8+ T-cell clone. PNAS 90 (1993) 11272-11276
145. Villadangos J.A., Galocha B., and Lopez de Castro J.A. Unusual topology of an HLA-B27 allospecific T cell epitope lacking peptide specificity. J. Immunol. 152 (1994) 2317-2323
146. Viret C., and Janeway Jr. C.A. MHC and T cell development. Immunol. Rev. 1 (1999) 91-104
147. Vogelsang G.B., Lee L., and Bensen-Kennedy D.M. Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant. Annu. Rev. Med. 54 (2003) 29-52
148. Wang W., Gulden P.H., Pierce R.A., Shabanowitz J., Man S.T., Hunt D.F., Engelhard V.H., and Shabanowitz J.A. A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity. J. Immunol. 158 (1997) 5797-5804 (published erratum appears in J. Immunol. 1999 Mar 1; 162(5):3106)
149. Wang Y., Rubtsov A., Heiser R., White J., Crawford F., Marrack P., and Kappler J.W. Using a baculovirus display library to identify MHC class I mimotopes. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 2476-2481
150. Wilson D.B., and Blyth J.N.P. Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response. J. Exp. Med. 128 (1968) 1157-1181
151. Wilson R.K., Lai E., Concannon P., Barth R.K., and Hood L.E. Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families. Immunol. Rev. 101 (1988) 149-172
152. Yadav R., Yoshimura Y., Boesteanu A., Christianson G.J., Ajayi W.U., Shashidharamurthy R., Stanic A.K., Roopenian D.C., and Joyce S. The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. J. Immunol. 170 (2003) 5133-5142
153. York I.A., and Rock K.L. Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 14 (1996) 369-396
154. Zernich D., Purcell A.W., Macdonald W.A., Kjer-Nielsen L., Ely L.K., Laham N., Crockford T., Mifsud N.A., Bharadwaj M., Chang L., Tait B.D., Holdsworth R., Brooks A.G., Bottomley S.P., Beddoe T., Peh C.A., Rossjohn J., and McCluskey J. Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J. Exp. Med. 200 (2004) 13-24
155. Zinkernagel R.M., and Doherty P.C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248 (1974) 701-702
156. Zinkernagel R.M., Callahan G.N., Klein J., and Dennert G. Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature 271 (1978) 251-253