Experimental Rhodococcus equi and equine infectious anemia virus DNA vaccination in adult and neonatal horses: Effect of IL-12, dose, and route

Vaccine

Volumn 25, Issue 43, 2007, Pages 7582-7597

  Mealey, R H ^a   Stone, D M ^a   Hines, M T ^a   Alperin, D C ^a   Littke, M H ^a   Leib, S R ^a   Leach, S E ^a   Hines, S A ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Equine tetramers; Gag p15 p26; VapA

Indexed keywords

ADJUVANT; BACTERIAL VACCINE; DNA VACCINE; INTERLEUKIN 12; TETRAMER; UNCLASSIFIED DRUG; VAPA VACCINE; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; DNA IMMUNIZATION; DRUG EFFECT; EQUINE INFECTIOUS ANEMIA VIRUS; EXPERIMENTAL INFECTION; FOAL; HORSE; HYPOTHESIS; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; RHODOCOCCUS EQUI; TH1 CELL;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; DRUG ADMINISTRATION ROUTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HORSES; IMMUNIZATION SCHEDULE; INFECTIOUS ANEMIA VIRUS, EQUINE; INTERLEUKIN-12; MICE; NIH 3T3 CELLS; RECOMBINANT PROTEINS; RHODOCOCCUS EQUI; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; VACCINES, DNA;

EID: 34848921475     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.07.055     Document Type: Article

References (65)

1. Gurunathan S., Klinman D.M., and Seder R.A. DNA vaccines: immunology, application, and optimization. Annu Rev Immunol 18 (2000) 927-974
2. Hokey D.A., and Weiner D.B. DNA vaccines for HIV: challenges and opportunities. Springer Semin Immunopathol 28 3 (2006) 267-279
3. Davis B.S., Chang G.J., Cropp B., Roehrig J.T., Martin D.A., Mitchell C.J., et al. West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 75 9 (2001) 4040-4047
4. Lunn D.P., Soboll G., Schram B.R., Quass J., McGregor M.W., Drape R.J., et al. Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine 17 18 (1999) 2245-2258
5. Soboll G., Nelson K.M., Leuthner E.S., Clark R.J., Drape R., Macklin M.D., et al. Mucosal co-administration of cholera toxin and influenza virus hemagglutinin-DNA in ponies generates a local IgA response. Vaccine 21 21-22 (2003) 3081-3092
6. Giese M., Bahr U., Jakob N.J., Kehm R., Handermann M., Muller H., et al. Stable and long-lasting immune response in horses after DNA vaccination against equine arteritis virus. Virus Genes 25 2 (2002) 159-167
7. Foote C.E., Love D.N., Gilkerson J.R., Rota J., Trevor-Jones P., Ruitenberg K.M., et al. Serum antibody responses to equine herpesvirus 1 glycoprotein D in horses, pregnant mares and young foals. Vet Immunol Immunopathol 105 1-2 (2005) 47-57
8. Minke J.M., Fischer L., Baudu P., Guigal P.M., Sindle T., Mumford J.A., et al. Use of DNA and recombinant canarypox viral (ALVAC) vectors for equine herpes virus vaccination. Vet Immunol Immunopathol 111 1-2 (2006) 47-57
9. Ruitenberg K.M., Love D.N., Gilkerson J.R., Wellington J.E., and Whalley J.M. Equine herpesvirus 1 (EHV-1) glycoprotein D DNA inoculation in horses with pre-existing EHV-1/EHV-4 antibody. Vet Microbiol 76 2 (2000) 117-127
10. Soboll G., Hussey S.B., Whalley J.M., Allen G.P., Koen M.T., Santucci N., et al. Antibody and cellular immune responses following DNA vaccination and EHV-1 infection of ponies. Vet Immunol Immunopathol 111 1-2 (2006) 81-95
11. Cantlon J.D., Gordy P.W., and Bowen R.A. Immune responses in mice, cattle and horses to a DNA vaccine for vesicular stomatitis. Vaccine 18 22 (2000) 2368-2374
12. Fischer L., Minke J., Dufay N., Baudu P., and Audonnet J.C. Rabies DNA vaccine in the horse: strategies to improve serological responses. Vaccine 21 31 (2003) 4593-4596
13. Cook R.F., Cook S.J., Bolin P.S., Howe L.J., Zhou W., Montelaro R.C., et al. Genetic immunization with codon-optimized equine infectious anemia virus (EIAV) surface unit (SU) envelope protein gene sequences stimulates immune responses in ponies. Vet Microbiol 108 1-2 (2005) 23-37
14. Bot A., and Bona C. Genetic immunization of neonates. Microbes Infect 4 4 (2002) 511-520
15. Meijer W.G., and Prescott J.F. Rhodococcus equi. Vet Res 35 4 (2004) 383-396
16. Breathnach C.C., Sturgill-Wright T., Stiltner J.L., Adams A.A., Lunn D.P., and Horohov D.W. Foals are interferon gamma-deficient at birth. Vet Immunol Immunopathol 112 3-4 (2006) 199-209
17. Patton K.M., McGuire T.C., Hines M.T., Mealey R.H., and Hines S.A. Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals. Infect Immun 73 4 (2005) 2083-2093
18. Hines S.A., Stone D.M., Hines M.T., Alperin D.C., Knowles D.P., Norton L.K., et al. Clearance of virulent but not avirulent Rhodococcus equi from the lungs of adult horses is associated with intracytoplasmic gamma interferon production by CD4+ and CD8+ T lymphocytes. Clin Diagn Lab Immunol 10 2 (2003) 208-215
19. Patton K.M., McGuire T.C., Fraser D.G., and Hines S.A. Rhodococcus equi-infected macrophages are recognized and killed by CD8+ T lymphocytes in a major histocompatibility complex class I-unrestricted fashion. Infect Immun 72 12 (2004) 7073-7083
20. Lopez A.M., Hines M.T., Palmer G.H., Knowles D.P., Alperin D.C., and Hines S.A. Analysis of anamnestic immune responses in adult horses and priming in neonates induced by a DNA vaccine expressing the vapA gene of Rhodococcus equi. Vaccine 21 25-26 (2003) 3815-3825
21. Ottenhoff T.H., and Verreck F.A. Hoeve MA, van de Vosse E. Control of human host immunity to mycobacteria. Tuberculosis (Edinb) 85 1-2 (2005) 53-64
22. Pertmer T.M., Oran A.E., Madorin C.A., and Robinson H.L. Th1 genetic adjuvants modulate immune responses in neonates. Vaccine 19 13-14 (2001) 1764-1771
23. McMonagle E.L., Taylor S., van Zuilekom H., Sanders L., Scholtes N., Keanie L.J., et al. Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems. Equine Vet J 33 7 (2001) 693-698
24. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44 2 (1986) 283-292
25. Chizzonite R., Truitt T., Podlaski F.J., Wolitzky A.G., Quinn P.M., Nunes P., et al. IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J Immunol 147 5 (1991) 1548-1556
26. Gately M.K., Desai B.B., Wolitzky A.G., Quinn P.M., Dwyer C.M., Podlaski F.J., et al. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 147 3 (1991) 874-882
27. McGuire T.C., O'Rourke K.I., Baszler T.V., Leib S.R., Brassfield A.L., and Davis W.C. Expression of functional protease and subviral particles by vaccinia virus containing equine infectious anaemia virus gag and 5' pol genes. J Gen Virol 75 Pt 4 (1994) 895-900
28. Mealey R.H., Zhang B., Leib S.R., Littke M.H., and McGuire T.C. Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus. Virology 313 2 (2003) 537-552
29. McGuire T.C., Leib S.R., Mealey R.H., Fraser D.G., Prieur D.J., and Presentation. binding affinity of equine infectious anemia virus CTL envelope and matrix protein epitopes by an expressed equine classical MHC class I molecule. J Immunol 171 4 (2003) 1984-1993
30. Mealey R.H., Sharif A., Ellis S.A., Littke M.H., Leib S.R., and McGuire T.C. Early detection of dominant Env-specific and subdominant Gag-specific CD8+ lymphocytes in equine infectious anemia virus-infected horses using major histocompatibility complex class I/peptide tetrameric complexes. Virology 339 1 (2005) 110-126
31. Lopez A.M., Hines M.T., Palmer G.H., Alperin D.C., and Hines S.A. Identification of pulmonary T-lymphocyte and serum antibody isotype responses associated with protection against Rhodococcus equi. Clin Diagn Lab Immunol 9 6 (2002) 1270-1276
32. Tan C., Prescott J.F., Patterson M.C., and Nicholson V.M. Molecular characterization of a lipid-modified virulence-associated protein of Rhodococcus equi and its potential in protective immunity. Can J Vet Res 59 1 (1995) 51-59
33. Hines M.T., Paasch K.M., Alperin D.C., Palmer G.H., Westhoff N.C., and Hines S.A. Immunity to Rhodococcus equi: antigen-specific recall responses in the lungs of adult horses. Vet Immunol Immunopathol 79 1-2 (2001) 101-114
34. Wada R., Kamada M., Anzai T., Nakanishi A., Kanemaru T., Takai S., et al. Pathogenicity and virulence of Rhodococcus equi in foals following intratracheal challenge. Vet Microbiol 56 3-4 (1997) 301-312
35. Fraser D.G., Leib S.R., Zhang B.S., Mealey R.H., Brown W.C., and McGuire T.C. Lymphocyte proliferation responses induced to broadly reactive Th peptides did not protect against equine infectious anemia virus challenge. Clin Diagn Lab Immunol 12 8 (2005) 983-993
36. Fraser D.G., Oaks J.L., Brown W.C., and McGuire T.C. Identification of broadly recognized. T helper 1 lymphocyte epitopes in an equine lentivirus. Immunology 105 3 (2002) 295-305
37. Allen G., Yeargan M., Costa L.R., and Cross R. Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1. J Virol 69 1 (1995) 606-612
38. Kohler A.K., Stone D.M., Hines M.T., Byrne B.A., Alperin D.C., Norton L.K., et al. Rhodococcus equi secreted antigens are immunogenic and stimulate a type 1 recall response in the lungs of horses immune to R. equi infection. Infect Immun 71 11 (2003) 6329-6337
39. Sheoran A.S., Lunn D.P., and Holmes M.A. Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet Immunol Immunopathol 62 2 (1998) 153-165
40. Chung C., Mealey R.H., and McGuire T.C. CTL from EIAV carrier horses with diverse MHC class I alleles recognize epitope clusters in Gag matrix and capsid proteins. Virology 327 1 (2004) 144-154
41. McGuire T.C., Tumas D.B., Byrne K.M., Hines M.T., Leib S.R., Brassfield A.L., et al. Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins. J Virol 68 3 (1994) 1459-1467
42. Siliciano R.F., Keegan A.D., Dintzis R.Z., Dintzis H.M., and Shin H.S. The interaction of nominal antigen with T cell antigen receptors. I. Specific binding of multivalent nominal antigen to cytolytic T cell clones. J Immunol 135 2 (1985) 906-914
43. Blanchard-Channell M., Moore P.F., and Stott J.L. Characterization of monoclonal antibodies specific for equine homologues of CD3 and CD5. Immunology 82 4 (1994) 548-554
44. Lunn D.P., Holmes M.A., Antczak D.F., Agerwal N., Baker J., Bendali-Ahcene S., et al. Report of the Second Equine Leucocyte Antigen Workshop, Squaw valley, California, July 1995. Vet Immunol Immunopathol 62 2 (1998) 101-143
45. Kydd J., Antczak D.F., Allen W.R., Barbis D., Butcher G., Davis W., et al. Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991. Vet Immunol Immunopathol 42 1 (1994) 3-60
46. Bailey E. Identification and genetics of horse lymphocyte alloantigens. Immunogenetics 11 5 (1980) 499-506
47. Bailey E. Population studies on the ELA system in American standardbred and thoroughbred mares. Anim Blood Groups Biochem Genet 14 3 (1983) 201-211
48. Terasaki P.I., Bernoco D., Park M.S., Ozturk G., and Iwaki Y. Microdroplet testing for HLA-A, -B, -C, and -D antigens, The Phillip Levine Award Lecture. Am J Clin Pathol 69 2 (1978) 103-120
49. Gillessen S., Carvajal D., Ling P., Podlaski F.J., Stremlo D.L., Familletti P.C., et al. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol 25 1 (1995) 200-206
50. Heinzel F.P., Hujer A.M., Ahmed F.N., and Rerko R.M. In vivo production and function of IL-12 p40 homodimers. J Immunol 158 9 (1997) 4381-4388
51. Kato K., Shimozato O., Hoshi K., Wakimoto H., Hamada H., Yagita H., et al. Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc Natl Acad Sci USA 93 17 (1996) 9085-9089
52. Barouch D.H., Fu T.M., Montefiori D.C., Lewis M.G., Shiver J.W., and Letvin N.L. Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys. Immunol Lett 79 1-2 (2001) 57-61
53. Barouch D.H., Santra S., Schmitz J.E., Kuroda M.J., Fu T.M., Wagner W., et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290 5491 (2000) 486-492
54. Egan M.A., Chong S.Y., Megati S., Montefiori D.C., Rose N.F., Boyer J.D., et al. Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus. AIDS Res Hum Retroviruses 21 7 (2005) 629-643
55. Schadeck E.B., Sidhu M., Egan M.A., Chong S.Y., Piacente P., Masood A., et al. A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques. Vaccine 24 21 (2006) 4677-4687
56. Lee Y.L., Ye Y.L., Yu C.I., Wu Y.L., Lai Y.L., Ku P.H., et al. Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma. Hum Gene Ther 12 17 (2001) 2065-2079
57. Chong S.Y., Egan M.A., Kutzler M., Megati S., Masood A., Roopchard V., et al. Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques. Vaccine (2007)
58. Breathnach C.C., Clark H.J., Clark R.C., Olsen C.W., Townsend H.G., and Lunn D.P. Immunization with recombinant modified vaccinia Ankara (rMVA) constructs encoding the HA or NP gene protects ponies from equine influenza virus challenge. Vaccine 24 8 (2006) 1180-1190
59. Breathnach C.C., Rudersdorf R., and Lunn D.P. Use of recombinant modified vaccinia Ankara viral vectors for equine influenza vaccination. Vet Immunol Immunopathol 98 3-4 (2004) 127-136
60. Soboll G., Horohov D.W., Aldridge B.M., Olsen C.W., McGregor M.W., Drape R.J., et al. Regional antibody and cellular immune responses to equine influenza virus infection, and particle mediated DNA vaccination. Vet Immunol Immunopathol 94 1-2 (2003) 47-62
61. Siegrist C.A. Neonatal and early life vaccinology. Vaccine 19 25-26 (2001) 3331-3346
62. Chang G.J., Davis B.S., Hunt A.R., Holmes D.A., and Kuno G. Flavivirus DNA vaccines: current status and potential. Ann N Y Acad Sci 951 (2001) 272-285
63. Powell K. DNA vaccines-back in the saddle again?. Nat Biotechnol 22 7 (2004) 799-801
64. Chang G.J., Hunt A.R., and Davis B. A single intramuscular injection of recombinant plasmid DNA induces protective immunity and prevents Japanese encephalitis in mice. J Virol 74 9 (2000) 4244-4252
65. Zhang M.J., Wang M.J., Jiang S.Z., and Ma W.Y. Passive protection of mice, goats, and monkeys against Japanese encephalitis with monoclonal antibodies. J Med Virol 29 2 (1989) 133-138