CGRP, PACAP, and VIP modulate langerhans cell function by inhibiting NF-κB activation

Journal of Investigative Dermatology

Volumn 127, Issue 10, 2007, Pages 2357-2367

  Ding, Wanhong ^a   Wagner, John A ^a   Granstein, Richard D ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAY 11 7085; CALCITONIN GENE RELATED PEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NEUROPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; BAY 11-7085; I KAPPA B KINASE; NITRILE; SULFONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL FUNCTION; CLONING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; FEMALE; GENE INACTIVATION; IN VITRO STUDY; LANGERHANS CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CELL LINE; FEMALE; I-KAPPA B KINASE; LANGERHANS CELLS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; NF-KAPPA B; NITRILES; PHOSPHORYLATION; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; SIGNAL TRANSDUCTION; SULFONES; TUMOR NECROSIS FACTOR-ALPHA; VASOACTIVE INTESTINAL PEPTIDE;

EID: 34848914339     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700858     Document Type: Article

References (45)

1. Ardeshna KM, Pizzey AR, Devereux S, Khwaja A (2000) The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96:1039-46
2. Asahina A, Hosoi J, Beissert S, Stratigos A, Granstein RD (1995) Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J Immunol 154:3056-61
3. Bennett CL, van Rijn E, Jung S, Inaba K, Steinman RM, Kapsenberg ML et al. (2005) Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169:569-76
4. Brain SD, Williams TJ (1988) Neuropharmacology of peptides in skin. Semin Dermatol 7:278-83
5. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J (1992) GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258-61
6. Cumberbatch M, Bhushan M, Dearman RJ, Kimber I, Griffiths CE (2003) IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin. Clin Exp Immunol 132:352-9
7. Cumberbatch M, Griffiths CE, Tucker SC, Dearman RJ, Kimber I (1999) Tumour necrosis factor-alpha induces Langerhans cell migration in humans. Br J Dermatol 141:192-200
8. de Saint-Vis B, Fugier-Vivier I, Massacrier C, Gaillard C, Vanbervliet B, Ait-Yahia S et al. (1998) The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J Immunol 160:1666-76
9. Delgado M, Munoz-Elias EJ, Martinez C, Gomariz RP, Ganea D (1999) VIP and PACAP38 modulate cytokine and nitric oxide production in peritoneal macrophages and macrophage cell lines. Ann NY Acad Sci 897:401-14
10. Feldmann M, Andreakos E, Smith C, Bondeson J, Yoshimura S, Kiriakidis S et al. (2002) Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Ann Rheum Dis 61(Suppl. 2):ii13-8
11. Fujita H, Asahina A, Tada Y, Fujiwara H, Tamaki K (2005) Type I interferons inhibit maturation and activation of mouse Langerhans cells. J Invest Dermatol 125:126-33
12. Ghosh S, May MJ, Kopp EB (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Ann Rev Immunol 16:225-60
13. Grabbe S, Bruvers S, Granstein RD (1992) Effects of immunomodulatory cytokines on the presentation of tumor-associated antigens by epidermal Langerhans cells. J Invest Dermatol 99:66S-8S
14. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A et al. (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363:159-63
15. Jeon YJ, Han SH, Kang JS, Koh WS, Yang KH (1999) Acetylaminofluorene inhibits nitric oxide production in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel activation. Toxicol Lett 104:195-202
16. Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ (2005) Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23:611-20
17. Kissenpfennig A, Henri S, Dubois B, Laplace-Builhe C, Perrin P, Romani N et al. (2005) Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643-54
18. Kodali S, Ding W, Huang J, Seiffert K, Wagner JA, Granstein RD (2004) Vasoactive intestinal peptide modulates Langerhans cell immune function. J Immunol 173:6082-8
19. Kodali S, Friedman I, Ding W, Seiffert K, Wagner JA, Granstein RD (2003) Pituitary adenylate cyclase-activating polypeptide inhibits cutaneous immune function. Eur J Immunol 33:3070-9
20. Laburthe M, Couvineau A, Marie JC (2002) VPAC receptors for VIP and PACAP. Receptors Channels 8:137-53
21. Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725
22. Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, Ohta T et al. (2004) Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models. J Biol Chem 279:23477-85
23. Mulder H, Jongsma H, Zhang Y, Gebre-Medhin S, Sundler F, Danielsen N (1999) Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation. Mol Neurobiol 19:229-53
24. Odum L, Petersen LJ, Skov PS, Ebskov LB (1998) Pituitary adenylate cyclase activating polypeptide (PACAP) is localized in human dermal neurons and causes histamine release from skin mast cells. Inflamm Res 47:488-92
25. Pettit AR, Quinn C, MacDonald KP, Cavanagh LL, Thomas G, Townsend W et al. (1997) Nuclear localization of RelB is associated with effective antigen-presenting cell function. J Immunol 159:3681-91
26. Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T et al. (1997) Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272:21096-103
27. Poligone B, Weaver DJ Jr, Sen P, Baldwin AS Jr, Tisch R (2002) Elevated NFkappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol 168:188-96
28. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P (1998) Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 188:2175-80
29. Schmitt D (1999) Immune functions of the human skin. Models of in vitro studies using Langerhans cells. Cell Biol Toxicol 15:41-5
30. Schreiber S, Kilgus O, Payer E, Kutil R, Elbe A, Mueller C et al. (1992) Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures. J Immunol 149:3524-34
31. Schulze E, Witt M, Fink T, Hofer A, Funk RH (1997) Immunohistochemical detection of human skin nerve fibers. Acta Histochem 99:301-9
32. Seiffert K, Hosoi J, Torii H, Ozawa H, Ding W, Campton K (2002) Catecholamines inhibit the antigen-presenting capability of epidermal Langerhans cells. J Immunol 168:6128-35
33. Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M et al. (2003) NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol 170:1770-80
34. Sherwood NM, Krueckl SL, McRory JE (2000) The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocr Rev 21:619-700
35. Steinman R, Hoffman L, Pope M (1995) Maturation and migration of cutaneous dendritic cells. J Invest Dermatol 105:2S-7S
36. Takashima A, Edelbaum D, Kitajima T, Shadduck RK, Gilmore GL, Xu S et al. (1995) Colony-stimulating factor-1 secreted by fibroblasts promotes the growth of dendritic cell lines (XS series) derived from murine epidermis. J Immunol 154:5128-35
37. Thomas PG, Carter MR, Da'dara AA, DeSimone TM, Harn DA (2005) A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation. J Immunol 175:2082-90
38. Torii H, Hosoi J, Asahina A, Granstein RD (1997) Calcitonin gene-related peptide and Langerhans cell function. J Investig Dermatol Symp Proc 2:82-6
39. Trede NS, Tsytsykova AV, Chatila T, Goldfeld AE, Geha RS (1995) Transcriptional activation of the human TNF-alpha promoter by super-antigen in human monocytic cells: role of NF-kappa B. J Immunol 155:902-8
40. Viatour P, Merville MP, Bours V, Chariot A (2005) Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 30:43-52
41. Wang B, Fujisawa H, Zhuang L, Kondo S, Shivji GM, Kim CS et al. (1997) Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75. J Immunol 159:6148-55
42. Xie QW, Kashiwabara Y, Nathan C (1994) Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269:4705-8
43. Xu S, Ariizumi K, Edelbaum D, Bergstresser PR, Takashima A (1995) Cytokine-dependent regulation of growth and maturation in murine epidermal dendritic cell lines. Eur J Immunol 25:1018-24
44. Yao J, Mackman N, Edgington TS, Fan ST (1997) Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors. J Biol Chem 272:17795-801
45. Zaidi M, Moonga BS, Bevis PJ, Bascal ZA, Breimer LH (1990) The calcitonin gene peptides: biology and clinical relevance. Crit Rev Clin Lab Sci 28:109-74