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Volumn 9, Issue 27, 2007, Pages 1-13

The molecular pathogenesis of Paget disease of bone

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BISPHOSPHONIC ACID DERIVATIVE; HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN P62; RECOMBINANT OSTEOPROTEGERIN; SEQUESTOSOME 1; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN;

EID: 34848912628     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S1462399407000464     Document Type: Review
Times cited : (41)

References (90)
  • 2
    • 0035999447 scopus 로고    scopus 로고
    • Paget's disease in an archeological population
    • Rogers, J., Jeffrey, D.R. and Watt, I. (2002) Paget's disease in an archeological population. J Bone Miner Res 17, 1127-1134
    • (2002) J Bone Miner Res , vol.17 , pp. 1127-1134
    • Rogers, J.1    Jeffrey, D.R.2    Watt, I.3
  • 3
    • 0032954603 scopus 로고    scopus 로고
    • The epidemiology of Paget's disease in Britain: Is the prevalence decreasing?
    • Cooper, C. et al. (1999) The epidemiology of Paget's disease in Britain: is the prevalence decreasing? J Bone Miner Res 14, 192-197
    • (1999) J Bone Miner Res , vol.14 , pp. 192-197
    • Cooper, C.1
  • 4
    • 25144442611 scopus 로고    scopus 로고
    • Genetics of Paget's disease of bone
    • Daroszewska, A. and Ralston, S.H. (2005) Genetics of Paget's disease of bone. Clin Sci (Lond) 109, 257-263
    • (2005) Clin Sci (Lond) , vol.109 , pp. 257-263
    • Daroszewska, A.1    Ralston, S.H.2
  • 6
    • 0036177990 scopus 로고    scopus 로고
    • Incidence and natural history of Paget's disease of bone in England and Wales
    • van Staa, T.P. et al. (2002) Incidence and natural history of Paget's disease of bone in England and Wales. J Bone Miner Res 17, 465-471
    • (2002) J Bone Miner Res , vol.17 , pp. 465-471
    • van Staa, T.P.1
  • 7
    • 0022634225 scopus 로고
    • Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 60 years
    • Huvos, A.G. (1986) Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 60 years. Cancer 57, 1442-1449
    • (1986) Cancer , vol.57 , pp. 1442-1449
    • Huvos, A.G.1
  • 8
    • 0032868676 scopus 로고    scopus 로고
    • Cell biology of Paget's disease
    • Reddy, S.V. et al. (1999) Cell biology of Paget's disease. J Bone Miner Res 14, Suppl 2, 3-8
    • (1999) J Bone Miner Res , vol.14 , Issue.SUPPL. 2 , pp. 3-8
    • Reddy, S.V.1
  • 9
    • 0018275969 scopus 로고
    • Radiological prevalence of Paget's disease of bone in British migrants to Australia
    • Gardner, M.J., Guyer, P.B. and Barker, D.J. (1978) Radiological prevalence of Paget's disease of bone in British migrants to Australia. Br Med J 1, 1655-1657
    • (1978) Br Med J , vol.1 , pp. 1655-1657
    • Gardner, M.J.1    Guyer, P.B.2    Barker, D.J.3
  • 10
    • 0028221605 scopus 로고
    • Epidemiological aspects of Paget's disease: Family history and relationship to other medical conditions
    • Siris, E.S. (1994) Epidemiological aspects of Paget's disease: Family history and relationship to other medical conditions. Semin Arthritis Rheum 23, 222-225
    • (1994) Semin Arthritis Rheum , vol.23 , pp. 222-225
    • Siris, E.S.1
  • 12
    • 0028914326 scopus 로고
    • Frequency and characteristics of familial aggregation of Paget's disease of bone
    • Morales-Piga, A.A. et al. (1995) Frequency and characteristics of familial aggregation of Paget's disease of bone. J Bone Miner Res 10, 663-670
    • (1995) J Bone Miner Res , vol.10 , pp. 663-670
    • Morales-Piga, A.A.1
  • 13
    • 0034065196 scopus 로고    scopus 로고
    • Familial Paget's disease of bone: Patterns of inheritance and frequency of linkage to chromosome 18q
    • Hocking, L. et al. (2000) Familial Paget's disease of bone: Patterns of inheritance and frequency of linkage to chromosome 18q. Bone 26, 577-580
    • (2000) Bone , vol.26 , pp. 577-580
    • Hocking, L.1
  • 14
    • 0031778038 scopus 로고    scopus 로고
    • Paget's disease of bone: Evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity
    • Haslam, S.I. et al. (1998) Paget's disease of bone: Evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity. J Bone Miner Res 13, 911-917
    • (1998) J Bone Miner Res , vol.13 , pp. 911-917
    • Haslam, S.I.1
  • 15
    • 11944268320 scopus 로고    scopus 로고
    • SQSTM1 and Paget's disease of bone
    • Layfield, R. and Hocking, L.J. (2004) SQSTM1 and Paget's disease of bone. Calcif Tissue Int 75, 347-357
    • (2004) Calcif Tissue Int , vol.75 , pp. 347-357
    • Layfield, R.1    Hocking, L.J.2
  • 16
    • 1842483843 scopus 로고    scopus 로고
    • Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
    • Watts, G.D. et al. (2004) Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Nat Genet 36, 377-381
    • (2004) Nat Genet , vol.36 , pp. 377-381
    • Watts, G.D.1
  • 17
    • 0442325388 scopus 로고    scopus 로고
    • The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
    • Duran, A. et al. (2004) The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell 6, 303-309
    • (2004) Dev Cell , vol.6 , pp. 303-309
    • Duran, A.1
  • 18
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • Teitelbaum, S.L. and Ross, F.P. (2003) Genetic regulation of osteoclast development and function. Nat Rev Genet 4, 638-649
    • (2003) Nat Rev Genet , vol.4 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 19
    • 0036094026 scopus 로고    scopus 로고
    • Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone
    • Laurin, N. et al. (2002) Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am J Hum Genet 70, 1582-1588
    • (2002) Am J Hum Genet , vol.70 , pp. 1582-1588
    • Laurin, N.1
  • 20
    • 0037108914 scopus 로고    scopus 로고
    • Domain specific mutations in Sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease
    • Hocking, L.J. et al. (2002) Domain specific mutations in Sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease. Hum Mol Genet 11, 2735-2739
    • (2002) Hum Mol Genet , vol.11 , pp. 2735-2739
    • Hocking, L.J.1
  • 21
    • 0142148013 scopus 로고    scopus 로고
    • Three novel mutations in SQSTM1 identified in familial Paget's disease of bone
    • Johnson-Pais, T.L. et al. (2003) Three novel mutations in SQSTM1 identified in familial Paget's disease of bone. J Bone Miner Res 18, 1748-1753
    • (2003) J Bone Miner Res , vol.18 , pp. 1748-1753
    • Johnson-Pais, T.L.1
  • 22
    • 2942709744 scopus 로고    scopus 로고
    • Identification of SQSTM1 mutations in familial Paget's disease in Australian pedigrees
    • Good, D.A. et al. (2004) Identification of SQSTM1 mutations in familial Paget's disease in Australian pedigrees. Bone 35, 277-282
    • (2004) Bone , vol.35 , pp. 277-282
    • Good, D.A.1
  • 23
    • 4444335629 scopus 로고    scopus 로고
    • Evaluation of the role of the SQSTM1 gene in sporadic Belgian patients with Paget's disease
    • Beyens, G. et al. (2004) Evaluation of the role of the SQSTM1 gene in sporadic Belgian patients with Paget's disease. Calcif Tissue Int 75, 144-152
    • (2004) Calcif Tissue Int , vol.75 , pp. 144-152
    • Beyens, G.1
  • 24
    • 2342493320 scopus 로고    scopus 로고
    • Familial Paget's disease in The Netherlands: Occurrence, identification of new mutations in the sequestosome 1 gene, and their clinical associations
    • Eekhoff, E.W. et al. (2004) Familial Paget's disease in The Netherlands: occurrence, identification of new mutations in the sequestosome 1 gene, and their clinical associations. Arthritis Rheum 50, 1650-1654
    • (2004) Arthritis Rheum , vol.50 , pp. 1650-1654
    • Eekhoff, E.W.1
  • 25
    • 8644267864 scopus 로고    scopus 로고
    • Two novel mutations at exon 8 of Sequestosome 1 gene (SQSTM1) in an Italian serie of patients affected by Paget's disease of bone (PDB)
    • Falchetti, A. et al. (2004) Two novel mutations at exon 8 of Sequestosome 1 gene (SQSTM1) in an Italian serie of patients affected by Paget's disease of bone (PDB). J Bone Miner Res 19, 1013-1017
    • (2004) J Bone Miner Res , vol.19 , pp. 1013-1017
    • Falchetti, A.1
  • 26
    • 4544371010 scopus 로고    scopus 로고
    • Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: Genotype phenotype correlation, functional analysis and structural consequences
    • Hocking, L.J. et al. (2004) Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: Genotype phenotype correlation, functional analysis and structural consequences. J Bone Miner Res 19, 1122-1127
    • (2004) J Bone Miner Res , vol.19 , pp. 1122-1127
    • Hocking, L.J.1
  • 27
    • 33845435884 scopus 로고    scopus 로고
    • Identification and molecular characterization of a novel splice-site mutation (G1205C) in the SQSTM1 gene causing Paget's disease of bone in an extended American family
    • Beyens, G. et al. (2006) Identification and molecular characterization of a novel splice-site mutation (G1205C) in the SQSTM1 gene causing Paget's disease of bone in an extended American family. Calcif Tissue Int 79, 281-288
    • (2006) Calcif Tissue Int , vol.79 , pp. 281-288
    • Beyens, G.1
  • 28
    • 33745510646 scopus 로고    scopus 로고
    • A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signalling and Paget's disease of bone with a severe phenotype
    • Rea, S.L. et al. (2006) A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signalling and Paget's disease of bone with a severe phenotype. J Bone Miner Res 21, 1136-1145
    • (2006) J Bone Miner Res , vol.21 , pp. 1136-1145
    • Rea, S.L.1
  • 29
    • 33846479861 scopus 로고    scopus 로고
    • Paget's disease of bone in the French population: Novel SQSTM1 mutations, functional analysis, and genotype-phenotype correlations
    • Collet, C. et al. (2007) Paget's disease of bone in the French population: Novel SQSTM1 mutations, functional analysis, and genotype-phenotype correlations. J Bone Miner Res 22, 310-317
    • (2007) J Bone Miner Res , vol.22 , pp. 310-317
    • Collet, C.1
  • 30
    • 0033987358 scopus 로고    scopus 로고
    • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
    • Hughes, A.E. et al. (2000) Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet 24, 45-48
    • (2000) Nat Genet , vol.24 , pp. 45-48
    • Hughes, A.E.1
  • 31
    • 0036133351 scopus 로고    scopus 로고
    • Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis
    • Whyte, M.P. and Hughes, A.E. (2002) Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis. J Bone Miner Res 17, 26-29
    • (2002) J Bone Miner Res , vol.17 , pp. 26-29
    • Whyte, M.P.1    Hughes, A.E.2
  • 32
    • 0038643034 scopus 로고    scopus 로고
    • Phenotypic characterisation of early onset Paget's disease of bone caused by a 27 bp duplication in the TNFRSF11A gene
    • Nakatsuka, K., Nishizawa, K. and Ralston, S.H. (2003) Phenotypic characterisation of early onset Paget's disease of bone caused by a 27 bp duplication in the TNFRSF11A gene. J Bone Miner Res 18, 1381-1385
    • (2003) J Bone Miner Res , vol.18 , pp. 1381-1385
    • Nakatsuka, K.1    Nishizawa, K.2    Ralston, S.H.3
  • 33
    • 0037130183 scopus 로고    scopus 로고
    • Osteoprotegerin deficiency and juvenile Paget's disease
    • Whyte, M.P. et al. (2002) Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med 347, 175-184
    • (2002) N Engl J Med , vol.347 , pp. 175-184
    • Whyte, M.P.1
  • 34
    • 18544371504 scopus 로고    scopus 로고
    • A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype
    • Cundy, T. et al. (2002) A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum Mol Genet 11, 2119-2127
    • (2002) Hum Mol Genet , vol.11 , pp. 2119-2127
    • Cundy, T.1
  • 35
    • 0036240410 scopus 로고    scopus 로고
    • VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line
    • Asai, T. et al. (2002) VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. Jpn J Cancer Res 93, 296-304
    • (2002) Jpn J Cancer Res , vol.93 , pp. 296-304
    • Asai, T.1
  • 36
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu, H. et al. (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A 96, 3540-3545
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3540-3545
    • Hsu, H.1
  • 37
    • 0032545465 scopus 로고    scopus 로고
    • The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
    • Galibert, L. et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem 273, 34120-341277
    • (1998) J Biol Chem , vol.273 , pp. 34120-341277
    • Galibert, L.1
  • 38
    • 18444390259 scopus 로고    scopus 로고
    • Distinct molecular mechanism for initiating TRAF6 signalling
    • Ye, H. et al. (2002) Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418, 443-447
    • (2002) Nature , vol.418 , pp. 443-447
    • Ye, H.1
  • 39
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng, L. et al. (2000) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1
  • 40
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-kappaB pathway
    • Chen, Z.J. (2005) Ubiquitin signalling in the NF-kappaB pathway Nat Cell Biol 7, 758-765
    • (2005) Nat Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 42
    • 4344712350 scopus 로고    scopus 로고
    • TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    • Kanayama, A. et al. (2004) TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15, 535-548
    • (2004) Mol Cell , vol.15 , pp. 535-548
    • Kanayama, A.1
  • 43
    • 2942703810 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
    • Jimi, E. et al. (2004) Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 10, 617-624
    • (2004) Nat Med , vol.10 , pp. 617-624
    • Jimi, E.1
  • 44
    • 33746644136 scopus 로고    scopus 로고
    • p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: A new insight into the pathogenesis of Paget's disease of bone
    • Yip, K.H. et al. (2006) p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: A new insight into the pathogenesis of Paget's disease of bone. Am J Pathol 169, 503-514
    • (2006) Am J Pathol , vol.169 , pp. 503-514
    • Yip, K.H.1
  • 45
    • 26944465404 scopus 로고    scopus 로고
    • Diverse polyubiquitin interaction properties of ubiquitin-associated domains
    • Raasi, S. et al. (2005) Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol 12, 708-714
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 708-714
    • Raasi, S.1
  • 46
    • 0029809134 scopus 로고    scopus 로고
    • p62, a phosphotyrosine-independent ligand of the SH2 domain of p561ck, belongs to a new class of ubiquitin-binding proteins
    • Vadlamudi, R.K. et al. (1996) p62, a phosphotyrosine-independent ligand of the SH2 domain of p561ck, belongs to a new class of ubiquitin-binding proteins. J Biol Chem 271, 20235-20237
    • (1996) J Biol Chem , vol.271 , pp. 20235-20237
    • Vadlamudi, R.K.1
  • 47
    • 33751259129 scopus 로고    scopus 로고
    • p62 mutations, ubiquitin recognition and Paget's disease of bone
    • Layfield, R. et al. (2006) p62 mutations, ubiquitin recognition and Paget's disease of bone. Biochem Soc Trans 34, 735-737
    • (2006) Biochem Soc Trans , vol.34 , pp. 735-737
    • Layfield, R.1
  • 48
    • 15344339092 scopus 로고    scopus 로고
    • Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations
    • Cavey, J.R. et al. (2005) Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations. J Bone Miner Res 20, 619-624
    • (2005) J Bone Miner Res , vol.20 , pp. 619-624
    • Cavey, J.R.1
  • 49
    • 33646597289 scopus 로고    scopus 로고
    • Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone
    • Cavey, J.R. et al. (2006) Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone. Calcif Tissue Int 78, 271-277
    • (2006) Calcif Tissue Int , vol.78 , pp. 271-277
    • Cavey, J.R.1
  • 50
    • 27444433045 scopus 로고    scopus 로고
    • The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    • Wooten, M.W. et al. (2005) The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem 280, 35625-35629
    • (2005) J Biol Chem , vol.280 , pp. 35625-35629
    • Wooten, M.W.1
  • 51
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
    • Takayanagi, H. et al. (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408, 600-605
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1
  • 52
    • 0033932526 scopus 로고    scopus 로고
    • Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone
    • Menaa, C. et al. (2000) Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone. J Clin Invest 105, 1833-1938
    • (2000) J Clin Invest , vol.105 , pp. 1833-1938
    • Menaa, C.1
  • 53
    • 0034937704 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology
    • Hofbauer, L.C. and Heufelder, A.E. (2001) Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology J Mol Med 79, 243-253
    • (2001) J Mol Med , vol.79 , pp. 243-253
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 54
    • 33845967453 scopus 로고    scopus 로고
    • Serum OPG and RANKL levels before and after intravenous bisphosphonate treatment in Paget's disease of bone
    • Martini, G. et al. (2007) Serum OPG and RANKL levels before and after intravenous bisphosphonate treatment in Paget's disease of bone. Bone 40, 457-463
    • (2007) Bone , vol.40 , pp. 457-463
    • Martini, G.1
  • 56
    • 31144470450 scopus 로고    scopus 로고
    • Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation
    • Weihl, C.C. et al. (2006) Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation. Hum Mol Genet 15, 189-199
    • (2006) Hum Mol Genet , vol.15 , pp. 189-199
    • Weihl, C.C.1
  • 57
    • 15444361471 scopus 로고    scopus 로고
    • Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha
    • Dai, R.M. et al. (1998) Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha. J Biol Chem 273, 3562-3573
    • (1998) J Biol Chem , vol.273 , pp. 3562-3573
    • Dai, R.M.1
  • 58
    • 0034918873 scopus 로고    scopus 로고
    • The ubiquitin protein catabolic disorders
    • Layfield, R. et al. (2001) The ubiquitin protein catabolic disorders. Neuropathol Appl Neurobiol 27, 171-179
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 171-179
    • Layfield, R.1
  • 59
    • 33645046107 scopus 로고    scopus 로고
    • Etiologic factors in Paget's disease of bone
    • Reddy, S.V. (2006) Etiologic factors in Paget's disease of bone. Cell Mol Life Sci 63, 391-398
    • (2006) Cell Mol Life Sci , vol.63 , pp. 391-398
    • Reddy, S.V.1
  • 60
    • 0019996989 scopus 로고
    • Ultrastructural features of the osteoclasts from Paget's disease of bone in relation to a viral etiology
    • Harvey, L. et al. (1982) Ultrastructural features of the osteoclasts from Paget's disease of bone in relation to a viral etiology. J Clin Pathol 35, 771-779
    • (1982) J Clin Pathol , vol.35 , pp. 771-779
    • Harvey, L.1
  • 61
    • 0017114175 scopus 로고
    • Nuclear inclusions in Paget's disease of bone
    • Mills, B.G. and Singer, F.R. (1976) Nuclear inclusions in Paget's disease of bone. Science 194, 201-202
    • (1976) Science , vol.194 , pp. 201-202
    • Mills, B.G.1    Singer, F.R.2
  • 62
    • 0021337486 scopus 로고
    • Evidence for both respiratory synctial virus and measles virus antigens in the osteoclasts of patients with Paget's disease of bone
    • Mills, B.G. et al. (1984) Evidence for both respiratory synctial virus and measles virus antigens in the osteoclasts of patients with Paget's disease of bone. Clin Orthop Relat Res 183, 303-311
    • (1984) Clin Orthop Relat Res , vol.183 , pp. 303-311
    • Mills, B.G.1
  • 63
    • 0018930834 scopus 로고
    • Bone tissue in Paget's disease of bone. Ultrastructure and immunocytology
    • Rebel, A. et al. (1980) Bone tissue in Paget's disease of bone. Ultrastructure and immunocytology. Arthritis Rheum 23, 1104-1144
    • (1980) Arthritis Rheum , vol.23 , pp. 1104-1144
    • Rebel, A.1
  • 64
    • 0032883330 scopus 로고    scopus 로고
    • Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone
    • Reddy, S.V. et al. (1999) Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone. Exp Hematol 27, 1528-1532
    • (1999) Exp Hematol , vol.27 , pp. 1528-1532
    • Reddy, S.V.1
  • 65
    • 0036133370 scopus 로고    scopus 로고
    • Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease
    • Friedrichs, W.E. et al. (2002) Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease. J Bone Miner Res 17, 145-151
    • (2002) J Bone Miner Res , vol.17 , pp. 145-151
    • Friedrichs, W.E.1
  • 66
    • 0033713488 scopus 로고    scopus 로고
    • A negative search for a paramyxoviral etiology of Paget's disease of bone: Molecular, immunological, and ultrastructural studies in UK patients
    • Helfrich, M.H. et al. (2000) A negative search for a paramyxoviral etiology of Paget's disease of bone: Molecular, immunological, and ultrastructural studies in UK patients. J Bone Miner Res 15, 2315-2329
    • (2000) J Bone Miner Res , vol.15 , pp. 2315-2329
    • Helfrich, M.H.1
  • 67
    • 34249704670 scopus 로고    scopus 로고
    • Multicenter blinded analysis of RT-PCR detection methods for paramyoviruses in relation to Paget's disease of bone
    • Ralston, S.H. et al. (2007) Multicenter blinded analysis of RT-PCR detection methods for paramyoviruses in relation to Paget's disease of bone. J Bone Miner Res 22, 569-577
    • (2007) J Bone Miner Res , vol.22 , pp. 569-577
    • Ralston, S.H.1
  • 68
    • 0034104393 scopus 로고    scopus 로고
    • Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype
    • Kurihara, N. et al. (2000) Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype. J Clin Invest 105, 607-614
    • (2000) J Clin Invest , vol.105 , pp. 607-614
    • Kurihara, N.1
  • 69
    • 0033963129 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease
    • Menaa, C. et al. (2000) 1,25-Dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease. J Bone Miner Res 15, 228-236
    • (2000) J Bone Miner Res , vol.15 , pp. 228-236
    • Menaa, C.1
  • 70
    • 15244347056 scopus 로고    scopus 로고
    • Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease
    • Kurihara, N. et al. (2004) Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease. J. Bone Miner Res 19, 1154-1164
    • (2004) J. Bone Miner Res , vol.19 , pp. 1154-1164
    • Kurihara, N.1
  • 71
    • 34247848056 scopus 로고    scopus 로고
    • Experimental models of Paget's disease
    • Kurihara, N. et al. (2006) Experimental models of Paget's disease. J Bone Miner Res 21, Suppl 2, 55-57
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 2 , pp. 55-57
    • Kurihara, N.1
  • 72
    • 33644529415 scopus 로고    scopus 로고
    • Expression of the measles virus nucleocapsid protein in osteoclasts in vivo induces Paget's disease like bone lesions in mice
    • Kurihara, N. et al. (2006) Expression of the measles virus nucleocapsid protein in osteoclasts in vivo induces Paget's disease like bone lesions in mice. J Bone Miner Res 21, 446-455
    • (2006) J Bone Miner Res , vol.21 , pp. 446-455
    • Kurihara, N.1
  • 73
    • 0032146198 scopus 로고    scopus 로고
    • Detection of canine distemper virus in 100% of Paget's disease samples by in situ reverse transcriptase polymerase chain reaction
    • Mee, A.P. et al. (1998) Detection of canine distemper virus in 100% of Paget's disease samples by in situ reverse transcriptase polymerase chain reaction. Bone 23, 171-175
    • (1998) Bone , vol.23 , pp. 171-175
    • Mee, A.P.1
  • 74
    • 33846433786 scopus 로고    scopus 로고
    • Canine distemper virus induces human osteoclastogenesis through NF-kappB and sequestosome1/p62 activation
    • Selby, P.L., Davies, M. and. Mee, A.P. (2006) Canine distemper virus induces human osteoclastogenesis through NF-kappB and sequestosome1/p62 activation. J Bone Miner Res 21, 1750-1756
    • (2006) J Bone Miner Res , vol.21 , pp. 1750-1756
    • Selby, P.L.1    Davies, M.2    Mee, A.P.3
  • 75
    • 33846516300 scopus 로고    scopus 로고
    • Is the prevalence of Paget's disease of bone decreasing?
    • Cundy, T. (2006) Is the prevalence of Paget's disease of bone decreasing? J Bone Miner Res 21, Suppl 2, 9-13
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 2 , pp. 9-13
    • Cundy, T.1
  • 76
    • 34247188567 scopus 로고    scopus 로고
    • Delayed development of Paget's disease in offspring inheriting SQSTM1 mutations
    • Bolland, M.J. et al. (2007) Delayed development of Paget's disease in offspring inheriting SQSTM1 mutations. J Bone Miner Res 22, 411-415
    • (2007) J Bone Miner Res , vol.22 , pp. 411-415
    • Bolland, M.J.1
  • 77
    • 0028221605 scopus 로고
    • Epidemiological aspects of Paget's disease: Family history and relationship to other medical conditions
    • Siris, E.S. (1994) Epidemiological aspects of Paget's disease: Family history and relationship to other medical conditions. Semin Arthritis Rheum 23, 222-225
    • (1994) Semin Arthritis Rheum , vol.23 , pp. 222-225
    • Siris, E.S.1
  • 78
    • 0036755763 scopus 로고    scopus 로고
    • Paget's disease of bone in Lancashire and arsenic pesticide in cotton mill wastewater: A speculative hypothesis
    • Lever, J.H. (2002) Paget's disease of bone in Lancashire and arsenic pesticide in cotton mill wastewater: A speculative hypothesis. Bone 31, 434-436
    • (2002) Bone , vol.31 , pp. 434-436
    • Lever, J.H.1
  • 79
    • 0038367669 scopus 로고    scopus 로고
    • Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts
    • Aono, J. et al. (2003) Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. Biochem Biophys Res Commun 305, 271-277
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 271-277
    • Aono, J.1
  • 80
    • 33646383590 scopus 로고    scopus 로고
    • Recent advances in understanding the mechanism of action of bisphosphonates
    • Coxon, F.P., Thompson, K. and. Rogers, M.J. (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr Opin Pharmacol 6, 307-312
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 307-312
    • Coxon, F.P.1    Thompson, K.2    Rogers, M.J.3
  • 82
    • 31744441494 scopus 로고    scopus 로고
    • Pharmacological therapy of Paget's and other metabolic bone diseases
    • Hoskins, D. (2006) Pharmacological therapy of Paget's and other metabolic bone diseases. Bone 38, Suppl 2, 3-7
    • (2006) Bone , vol.38 , Issue.SUPPL. 2 , pp. 3-7
    • Hoskins, D.1
  • 83
    • 33846219426 scopus 로고    scopus 로고
    • Clinical determinants of quality of life in Paget's disease of bone
    • Langston, A.L. et al. (2007) Clinical determinants of quality of life in Paget's disease of bone. Calcif Tissue Int 80, 1-9
    • (2007) Calcif Tissue Int , vol.80 , pp. 1-9
    • Langston, A.L.1
  • 84
    • 18844386517 scopus 로고    scopus 로고
    • Mechanism of osteoclast mediated bone resorption-rationale for the design of new therapeutics
    • Vaananen, K. (2005) Mechanism of osteoclast mediated bone resorption-rationale for the design of new therapeutics. Adv Drug Deliv Rev 57, 959-971
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 959-971
    • Vaananen, K.1
  • 85
    • 33748199511 scopus 로고    scopus 로고
    • OPG/membranous-RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation
    • Tat, S.K. et al. (2006) OPG/membranous-RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation. Bone 39, 706-715
    • (2006) Bone , vol.39 , pp. 706-715
    • Tat, S.K.1
  • 86
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung, M.R. et al. (2006) Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354, 821-831
    • (2006) N Engl J Med , vol.354 , pp. 821-831
    • McClung, M.R.1
  • 87
    • 24044504089 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin for juvenile Paget's disease
    • Cundy, T. et al. (2005) Recombinant osteoprotegerin for juvenile Paget's disease. N Engl J Med 353, 918-923
    • (2005) N Engl J Med , vol.353 , pp. 918-923
    • Cundy, T.1
  • 88
    • 34247848058 scopus 로고    scopus 로고
    • Clinical and cellular phenotypes associated with Sequestosome 1 (SQSTM1) mutations
    • Leach, R.J. et al. (2006) Clinical and cellular phenotypes associated with Sequestosome 1 (SQSTM1) mutations. J Bone Miner Res 21, Suppl 2, 45-50
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 2 , pp. 45-50
    • Leach, R.J.1
  • 89
    • 34247861003 scopus 로고    scopus 로고
    • Sequestosome 1: Mutation frequencies, haplotypes and phenotypes in familial Paget's disease of bone
    • Morisette, J., Laurin, N. and. Brown, J.P. (2006) Sequestosome 1: mutation frequencies, haplotypes and phenotypes in familial Paget's disease of bone. J Bone Miner Res 21, Suppl 2, 38-44
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 2 , pp. 38-44
    • Morisette, J.1    Laurin, N.2    Brown, J.P.3
  • 90
    • 33846009075 scopus 로고    scopus 로고
    • Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease
    • Kurihara, N. et al. (2007) Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease. J Clin Invest 117, 133-142
    • (2007) J Clin Invest , vol.117 , pp. 133-142
    • Kurihara, N.1


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