Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone

Calcified Tissue International

Volumn 78, Issue 5, 2006, Pages 271-277

  Cavey, J R ^a   Ralston, S H ^b   Sheppard, P W ^c   Ciani, B ^d   Gallagher, T R A ^d   Long, J E ^d   Searle, M S ^d   Layfield, R ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c BIOMOL International LP   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

p62; Paget's disease of bone; SQSTM1; Ubiquitin; Ubiquitin associated domain

Indexed keywords

GENE PRODUCT; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE RELATED PROTEIN; POLYUBIQUITIN; PROTEASOME; PROTEIN P62; SEPHAROSE; SQSTM1 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; BONE TURNOVER; CHROMOSOME 5Q; GEL FILTRATION; GENE; GENE MUTATION; GENETIC SUSCEPTIBILITY; MISSENSE MUTATION; PAGET BONE DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUESTOSOME 1 GENE; SIGNAL TRANSDUCTION; UBIQUITINATION; WESTERN BLOTTING; WILD TYPE;

BINDING SITES; BONE AND BONES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION, MISSENSE; OSTEITIS DEFORMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; UBIQUITINS;

EID: 33646597289     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-005-1299-6     Document Type: Article

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