Naturally occurring compounds affect glutamatergic neurotransmission in rat brain

Neurochemical Research

Volumn 32, Issue 11, 2007, Pages 1950-1956

  Martini, Lucia Helena ^a   Jung, Fernanda ^a   Soares, Felix Antunes ^a   Rotta, Liane Nanci ^b,c   Vendite, Deusa Aparecida ^a   Frizzo, Marcos Emilio Dos Santos ^a   Yunes, Rosendo A ^d   Calixto, João Batista ^d   Wofchuk, Susana ^a   Souza, Diogo O ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^c UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Antinociception; CNS; Glutamate transmision; Naturally occurring compounds; Side effects

Indexed keywords

ALPHA AMYRIN; AURANTIIN; BETA AMYRIN; GENISTEIN; GLUTAMIC ACID; HEDYOSMUM BRASILIENSE EXTRACT; JATROPHONE; LUPEOL; PLANT EXTRACT; POLYGODIAL; TORMENTIC ACID; UNCLASSIFIED DRUG;

ADRENERGIC TRANSMISSION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; ASTROCYTE; BINDING ASSAY; CHEMICAL PARAMETERS; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; SYNAPTIC MEMBRANE;

ANIMALS; BRAIN; DITERPENES; FLAVANONES; GENISTEIN; GLUTAMIC ACID; OLEANOLIC ACID; PLANT EXTRACTS; RATS; RATS, WISTAR; SESQUITERPENES; SYNAPTIC TRANSMISSION; SYNAPTOSOMES; TRITERPENES;

CITRUS; CRATAEVA NURVALA; DRIMYS WINTERI; GLYCINE MAX; HEDYOSMUM BRASILIENSE; OCOTEA SUAVEOLENS; PROTIUM KLEINII; RATTUS;

EID: 34848912499     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-007-9393-y     Document Type: Article

References (44)

1. Izquierdo I, Medina JH (1997) Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol Learn Mem 68:285-316
2. Ozawa S, Kamyiar H, Tsuzuki K (1998) Glutamate receptors in the mammalian cerebral nervous system. Prog Neurobiol 54:581-618
3. Segovia G, Porras A, Del Arco A et al (2001) Glutamatergic neurotransmission in aging: a critical perspective. Mech Ageing Dev 122:1-29
4. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1-105
5. Maragakis NJ, Rothstein JD (2001) Glutamate transporters in neurologic disease. Arch Neurol 58:365-370
6. Maragakis NJ, Rothstein JD (2004) Glutamate transporters: animal models to neurologic disease. Neurobiol Dis 15:461-473
7. Meldrum BS (2000) Glutamate as a neurotransmitter in the brain: Review of Physiology and Pathology. J Nutr 130:1007S-1015S
8. Chen Y, Swanson RA (2003) Astrocytes and brain injury. J Cereb Blood Flow Metab 23:137-149
9. Attwell D (2000) Brain uptake of glutamate: food for thought. J Nutr 130:1023S-1025S
10. Robinson MB, Dowd LA (1997) Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in mammalian central nervous system. Adv Pharmacol 37:69-115
11. 3H]GMP-PNP in rat cerebral cortex membrane. Neurochem Res 25:211-215
12. Scheidt C, Santos ARS, Ferreira J et al (2002) Evidence for the involvement of glutamatergic receptors in the antinociception caused in mice by the sesquiterpene drimanial. Neuropharmacology 43:340-347
13. Morton JF (1981) In: Thomas CC (ed) Atlas of medicinal plants in middle America-Bahamas to Yucatan. Springfield, USA p 219
14. Mendes GL, Santos ARS, Campos MM et al (1998) Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). Life Sci 63:369-381
15. Da Cunha FM, Fröde TS, Mendes GL et al (2001) Additional evidence for the anti-inflammatory and anti-allergic properties of the sesquiterpene polygodial. Life Sci 70:159-169
16. Beirith A, Santos ARS, Calixto JB et al (1999) Study of the antinociceptive action of the ethanolic extract and the triterpene 24-hydroxytormentic acid isolated from the stem bark of Ocotea suaveolens. Plant Med 65:50-55
17. Calixto JB, Sant'Ana AEG (1990) Evidence for the mechanism of the inhibitory Action of jatrophone in the isolated rat uterine muscle. Gen Pharmacol 21:117-122
18. Trentin AP, Santos ARS, Guedes A et al (1999) Antinociception caused by the extract of Hedyosmum brasiliense and its active principle, the sesquiterpene lactone 13-hydroxy-8,9-dehydroshizukanolide. Plant Med 65:517-521
19. Calixto JB, Santos ARS, Cechinel-Filho V et al (1998) A review of the genus Phyllanthus their chemistry, pharmacology and therapeutic potential. Med Res Rev 18:225-258
20. Calixto JB, Scheidt C, Otuki M et al (2001) Biological activity of plant extracts: novel analgesic drugs. Expert Opin Emerg Drugs 6:1-18
21. Otuki MF, Ferreira J, Lima FV et al (2005) Antinociceptive properties of mixture of α-amyrin and β-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Therap 313:310-318
22. Otuki MF, Vieira-Lima F, Malheiros A et al (2005) Topical antiinflammatory effects of the ether extract from Protium kleinii and α-amyrin pentacyclic triterpene. Eur J Pharmacol 507:253-259
23. Geetha T, Varalakshmi P (1999) Anticomplement activity of triterpenes from Cratevea nurvala stem bark in adjuvant arthritis in rats. Gen Pharmacol 32: 495-497
24. Sudhahar V, Kumar SA, Varalakshmi P (2006) Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia. Life Sci 78:1329-1335
25. Dugo P, Presti ML, Ohman M et al (2005) Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS. J Sep Sci 28:49-56
26. Kruk I, Aboul-Enein HY, Michalska T et al (2005) Scavenging of reative oxygen species by the plant phenols genistein and oleuropein. Luminescence 20:81-89
27. Jones DH, Matus AI (1974) Isolation of synaptic-plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation. Biochim Biophys Acta 356:276-287
28. Fykse EM, Fonnum FJ (1988) Uptake of γ-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain. J Neurochem 50:1237-1242
29. Tavares RG, Tasca CI, Santos CES et al (2000) Quinolinic acid inhibits uptake into synaptic vesicles from rat brain. Neuroreport 11:249-253
30. Naito S, Ueda T (1985) Characterization of glutamate uptake into synaptic vesicles. J Neurochem 44:99-109
31. Wolosker H, Souza DOG, De Méis LJ (1996) Regulation of glutamate transport into synaptic vesicles by chloride and proton gradient. J Biol Chem 271:11726-11731
32. Saneto RP, De Vellis J (1987) Neuronal and glial cells: cell culture of the central nervous system. In: Turner AJ, Brachelard HS (eds) Neurochemistry: a practical approach. IRL Press, Oxford, pp 27-63
33. Frizzo MES, Lara DR, Dahm KCS et al (2001) Activation of glutamate uptake by guanosine in primary astrocyte cultures. Neuroreport 12:879-881
34. Zelenaia O, Schlag BD, Gochenauer GE et al (2000) Epidermal growth receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphaidylinositol 3-kinase and transcription factor NF-kappaB. Mol Pharmacol 57:667-678
35. 1 fraction: homogeneity and morphology of subcelular fractions. Brain Res 441:59-71
36. Rocha JBT, Mello CF, Battastini AMO et al (1994) Dois procedimentos para isolar sinaptossomas usando gradientes de Percoll. Ciênc Nat Brasil 16:29-33
37. Migues PV, Leal RB, Mantovani M et al (1999) Synaptosomal glutamate release induced by the fraction BC2 from the venom of the sea anemone Bunadosoma caissarum. Neuroreport 1:67-70
38. Fontella FU, Vendite DA, Tabajara AS et al (2004) Repeated restrait stress alters hippocampal glutamate uptake and release in the rat. Neurochem Res 29:1703-1709
39. Lowry OH, Rosebrough NJ, Farr AL et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
40. Corrêa P (1978) Dicionário das plantas úteis do Brasil e das exóticas cultivadas. Rio de Janeiro: Imprensa Nacional 2:112
41. Tratsk KS, Campos MM, Vaz ZR et al (1997) Anti-allergic effects and oedema inhibition caused by the extract of Drymis winteri. Inflamm Res 46:509-514
42. Mendes GL, Santos ARS, Malheiros A et al (2000) Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial. J Pharmacol Exp Ther 292:164-172
43. André E, Ferreira J, Melheiros A et al (2004) Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeyde unsaturated sesquiterpenes polygodial and drimanial in rats. Neuropharmacology 46:590-597
44. Martini LH, Cereser L, Zanonato-Junior I et al (2006) The sesquiterpenes polygodial and drimanial in vitro affect glutamatergic transport in rat brain. Neurochem Res 31:431-438