Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae)

Life Sciences

Volumn 63, Issue 5, 1998, Pages 369-381

  Mendes, Gilboé L ^a   Santos, Adair R S ^a   Campos, Maria M ^a   Tratsk, Karla S ^a   Yunes, Rosendo A ^a   Cechinel Filho, Valdir ^b   Calixto, João B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Acetic acid; Anti hyperalgesia; Bradykinin; Capsaicin; Drymis winteri; Formalin; Mice; Polygodial; Rat; Substance P; Zymosan

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CAPSAICIN; CARRAGEENAN; KAOLIN; NALOXONE; POLYGODIAL; PROSTAGLANDIN E2; SESQUITERPENE DERIVATIVE; SUBSTANCE P; ZYMOSAN;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PURIFICATION; HOT PLATE TEST; HYPERALGESIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROMODULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ABDOMINAL PAIN; ACETIC ACID; ANIMALS; BRADYKININ; CAPSAICIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; HYPERALGESIA; MALE; MICE; MOTOR ACTIVITY; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SESQUITERPENES; SUBSTANCE P; ZYMOSAN;

ANIMALIA; DRYMIS; DRYMIS WINTERI; WINTERACEAE;

EID: 2042538315     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(98)00285-9     Document Type: Article

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