Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators

Acta Pharmacologica Sinica

Volumn 28, Issue 10, 2007, Pages 1698-1704

  Wang, Jue ^a   Xie, Xin ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Competitive binding; Epidermal growth factor receptor; High content screening; Receptor internalization

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR MODULATOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WJ 12;

ARTICLE; CELL ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; FLUORESCENCE ANALYSIS; HIGH CONTENT SCREENING ASSAY; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; PROTEIN PHOSPHORYLATION; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION;

BINDING, COMPETITIVE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENDOCYTOSIS; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HELA CELLS; HUMANS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; XENOBIOTICS;

EID: 34848900413     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00640.x     Document Type: Article

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