Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1

Journal of Immunology

Volumn 179, Issue 4, 2007, Pages 2419-2427

  Retter, Ida ^a   Chevillard, Christophe ^b,c,d   Scharfe, Maren ^a   Conrad, Ansgar ^a   Hafner, Martin ^a   Im, Tschong Hun ^a   Ludewig, Monika ^a   Nordsiek, Gabriele ^a   Severitt, Simone ^a   Thies, Stephanie ^a   Mauhar, America ^b   Blöcker, Helmut ^a   Müller, Werner ^a,e   Riblet, Roy ^b  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^c INSERM   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ALLELE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENE SEQUENCE; GENOME ANALYSIS; GERM LINE; HAPLOTYPE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE HOMOLOGY; ANIMAL; BAGG ALBINO MOUSE; COMPARATIVE STUDY; GENE DUPLICATION; GENETICS; GENOME; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR EVOLUTION; QUANTITATIVE TRAIT LOCUS; SPECIES DIFFERENCE;

ALLELES; ANIMALS; EVOLUTION, MOLECULAR; GENE DUPLICATION; GENOME; HAPLOTYPES; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; QUANTITATIVE TRAIT LOCI; SPECIES SPECIFICITY;

EID: 34848882174     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.4.2419     Document Type: Article

References (50)

1. Hozumi, N., and S. Tonegawa. 1976. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. Natl. Acad. Sci. USA 73: 3628-3632.
2. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302: 575-581.
3. Tutter, A., and R. Riblet. 1989. Evolution of the immunoglobulin heavy chain variable region (Igh-V) locus in the genus Mus. Immunogenetics 30: 315-329.
4. Brodeur, P. H., and R. Riblet. 1984. The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse: I. One hundred Igh-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14: 922-930.
5. H genes in inbred strains of mice. Immunogenetics 28: 125-135.
6. Waterston, R. H., K. Lindblad-Toh, E. Birney, J. Rogers, J. F. Abril, P. Agarwal, R. Agarwala, R. Ainscough, M. Alexandersson, P. An, et al. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420: 520-562.
7. Riblet, R. 2004. Immunoglobulin heavy chain genes of mouse. In Molecular Biology of B Cells. T. Honjo, F. W. Alt, and M. Neuberger, eds. Elsevier Academic, London, pp. 19-26.
8. H gene segments in the mouse and human genomes. J. Mol. Biol. 342: 131-143.
9. Johnston, C. M., A. L. Wood, D. J. Bolland, and A. E. Corcoran. 2006. Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain V region. J. Immunol. 176: 4221-4234.
10. Cobb, R. M., K. J. Oestreich, O. A. Osipovich, and E. M. Oltz. 2006. Accessibility control of V(D)J recombination. Adv. Immunol. 91: 45-109.
11. Yang, S. Y., S. D. Fugmann, and D. G. Schatz. 2006. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J. Exp. Med. 203: 2919-2928.
12. Zarrin, A. A., M. Tian, J. Wang, T. Borjeson, and F. W. Alt. 2005. Influence of switch region length on immunoglobulin class switch recombination. Proc. Natl. Acad. Sci. USA 102: 2466-2470.
13. Swiatek, P. J., and T. Gridley. 1993. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 7: 2071-2084.
14. Chevillard, C., J. Ozaki, C. D. Herring, and R. Riblet. 2002. A three-megabase yeast artificial chromosome contig spanning the C57BL mouse Igh locus. J. Immunol. 168: 5659-5666.
15. Herring, C. D., C. Chevillard, S. L. Johnston, P. J. Wettstein, and R. Riblet. 1998. Vector-hexamer PCR isolation of all insert ends from a YAC contig of the mouse Igh locus. Genome Res. 8: 673-681.
16. Staden, R. 1996. The Staden sequence analysis package. Mol. Biotechnol. 5: 233-241.
17. Retter, I., H. H. Althaus, R. Munch, and W. Muller. 2005. VBASE2, an integrative V gene database. Nucleic Acids Res. 33: D671-D674.
18. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.
19. Schwartz, S., Z. Zhang, K. A. Frazer, A. Smit, C. Riemer, J. Bouck, R. Gibbs, R. Hardison, and W. Miller. 2000. PipMaker: a web server for aligning two genomic DNA sequences. Genome Res. 10: 577-586.
20. Lefranc, M. P., V. Giudicelli, C. Ginestoux, J. Bodmer, W. Muller, R. Bontrop, M. Lemaitre, A. Malik, V. Barbie, and D. Chaume. 1999. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res. 27: 209-212.
21. Kumar, S., K. Tamura, and M. Nei. 2004. MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform. 5: 150-163.
22. Rice, P., I. Longden, and A. Bleasby. 2000. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet. 16: 276-277.
23. Giudicelli, V., D. Chaume, and M. P. Lefranc. 2005. IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 33: D256-D261.
24. H gene family. Mol. Biol. Evol. 11: 469-482.
25. Mainville, C. A., K. M. Sheehan, L. D. Klaman, C. A. Giorgetti, J. L. Press, and P. H. Brodeur. 1996. Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes. J. Immunol. 156: 1038-1046.
26. Williams, G. S., A. Martinez, A. Montalbano, A. Tang, A. Mauhar, K. M. Ogwaro, D. Merz, C. Chevillard, R. Riblet, and A. J. Feeney. 2001. Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location. J. Immunol. 167: 257-263.
27. H rearrangement violating the 12/23 rule. J. Exp. Med. 201: 341-348.
28. H and D gene probes. J. Immunol. 134: 2734-2739.
29. Reth, M. G., and F. W. Alt. 1984. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature 312: 418-423.
30. H rearrangement by promoter-enhancer approximation. Mol. Cell. Biol. 11: 2096-2107.
31. Chang, Y., C. J. Paige, and G. E. Wu. 1992. Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J. 11: 1891-1899.
32. Atkinson, M. J., Y. Chang, J. W. Celler, C. Huang, C. J. Paige, and G. E. Wu. 1994. Overusage of mouse DH gene segment, DFL16.1, is strain-dependent and determined by cis-acting elements. Dev. Immunol. 3: 283-295.
33. Nitschke, L., J. Kestler, T. Tallone, S. Pelkonen, and J. Pelkonen. 2001. Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage. J. Immunol. 166: 2540-2552.
34. H gene. Eur. J. Immunol. 19: 1849-1854.
35. H gene in the BALB/c mouse. Immunogenetics 37: 217-221.
36. Ye, J. 2004. The immunoglobulin IGHD gene locus in C57BL/6 mice. Immunogenetics 56: 399-404.
37. Akahori, Y., and Y. Kurosawa. 1997. Nucleotide sequences of all the γ gene loci of murine immunoglobulin heavy chains. Genomics 41: 100-104.
38. Shimizu, A., N. Takahashi, Y. Yaoita, and T. Honjo. 1982. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell 28: 499-506.
39. Martinez-Jean, C., G. Folch, and M. P. Lefranc. 2001. Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin κ (IGK) genes. Exp. Clin. Immunogenet. 18: 255-279.
40. Lieberman, R. 1978. Genetics of IgCH (allotype) locus in the mouse. Springer Semin. Immunopathol. 1: 7-30.
41. Kitamura, D., and K. Rajewsky. 1992. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356: 154-156.
42. Jung, S., K. Rajewsky, and A. Radbruch. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259: 984-987.
43. H genes correlates with allotype and idiotype markers. Eur. J. Immunol. 11: 1017-1020.
44. Brekke, K. M., and W. T. Garrard. 2004. Assembly and analysis of the mouse immunoglobulin κ gene sequence. Immunogenetics 56: 490-505.
45. Mostoslavsky, R., N. Singh, T. Tenzen, M. Goldmit, C. Gabay, S. Elizur, P. Qi, B. E. Reubinoff, A. Chess, H. Cedar, and Y. Bergman. 2001. Asynchronous replication and allelic exclusion in the immune system. Nature 414: 221-225.
46. Lyon, M. F. 2000. LINE-1 elements and X chromosome inactivation: a function for "junk" DNA? Proc. Natl. Acad. Sci. USA 97: 6248-6249.
47. Matsuda, F., K. Ishii, P. Bourvagnet, K. Kuma, H. Hayashida, T. Miyata, and T. Honjo. 1998. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J. Exp. Med. 188: 2151-2162.
48. Kawasaki, K., S. Minoshima, and N. Shimizu. 2000. Propagation and maintenance of the 119 human immunoglobulin Vλ genes and pseudogenes during evolution. J. Exp. Zool. 288: 120-134.
49. Kawasaki, K., S. Minoshima, E. Nakato, K. Shibuya, A. Shintani, S. Asakawa, T. Sasaki, H. G. Klobeck, G. Combriato, H. G. Zachau, and N. Shimizu. 2001. Evolutionary dynamics of the human immunoglobulin κlocus and the germline repertoire of the Vκ genes. Eur. J. Immunol. 31: 1017-1028.
50. Beck, J. A., S. Lloyd, M. Hafezparast, M. Lennon-Pierce, J. T. Eppig, M. F. Festing, and E. M. Fisher. 2000. Genealogies of mouse inbred strains. Nat. Genet. 24: 23-25.