Deletional mapping of fifteen mouse VH gene families reveals a common organization for three IgH haplotypes

Journal of Immunology

Volumn 156, Issue 3, 1996, Pages 1038-1046

  Mainville, Celine A ^a,b   Sheehan, Kevin M ^a,b   Klaman, Lori D ^a,b   Giorgetti, Carol A ^c   Press, Joan L ^c   Brodeur, Peter H ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; DNA LIBRARY; GENE DELETION; GENE LOCUS; GENE MAPPING; GENE REARRANGEMENT; HAPLOTYPE; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRE B LYMPHOCYTE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE, TRANSFORMED; CHROMOSOME MAPPING; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HAPLOTYPES; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SEQUENCE DELETION;

EID: 0030030180     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 14:575.
2. Lewis, S. M 1994 The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol 56 27.
3. Brodeur, P H., and R. Riblet 1984 The immunoglobulin heavy chain variable region (Igh-V) of the mouse. I One hundred Igh V genes comprise seven families of homologous genes. Eur. J. Immunol. 14:922.
4. Brodeur, P. H, M. A. Thompson, and R. Riblet. 1984. The content and organization of mouse Igh-V families In: Regulation of the Immune System. UCLA Symposia on Molecular and Cellular Biology. E. Sercarz, H. Cantor, and L. Chess, eds. Alan R. Liss, Inc, New York, p 445.
5. H gene families are found in VDJ regions of polyclonally activated B-lymphocytes. EMBO J. 4:2861.
6. H gene family. J. Immunol 140:4031
7. H gene family encodes anti-bromelinized mouse red blood cell autoantibodies. Eur. J. Immunol. 18:1521.
8. + (CD5) B cells. Eur. J Immunol. 19:2115.
9. H gene families. J. Immunol. 147.3215
10. Kofler, R, S Geley, H. Kofler, and A. Helmberg 1992 Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses. Immunol Rev 128:5.
11. H locus. J. Mol. Appl Genet. 1:245.
12. H region genes of the mouse are organized in overlapping clusters Eur. J. Immunol. 17:1351
13. H complex in the inbred strains. EMBO J. 6.2931.
14. H gene family clusters. J Exp. Med. 166:2261.
15. Meek, K., G Rathbun, L. Reininger, J-C. Jaton, R. Kofler, P. W Tucker, and J D Capra. 1990. Organization of the murine immunoglobulin VH complex: placement of two new VH families (VH10 and VH11) and analysis of VH family clustering and interdigitation. Mol Immunol. 27:1073.
16. H germline gene accounts for the major family of Ab1 and Ab3 (Ab1′) antibodies of the GAT system. J. Exp. Med. 163:573
17. Rosenberg, N., and D. Baltimore. 1976. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J. Exp Med. 143:1453.
18. Marcu, K B., J Banerji, N. A. Penncavage, R Lang, and N. Arnheim. 1980. 5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains. Cell 22:187.
19. H gene usage in adult mice EMBO J. 8:2313.
20. H and V6 genes in their (T,G)-A-L-specific repertoire. J. Immunol. 144:583.
21. Loh, D. Y., A. M. Bothwell, M E. White-Scharf, T. Imanishi-Kari, and D. Baltimore. 1983. Molecular basis of a mouse strain-specific anti-hapten response. Cell 33 85.
22. H exons in the primary repertoire of adult BALB/c mice. J. Immunol. 151:5364.
23. Sikder, S K., P. N. Ankolar, P. M. Kaladas, S. L. Morrison, amd E A Kabat. 1985. Sequences of variable regions of hybridoma antibodies to α(1→166) dextran in BALB/c and C57BL/6 mice. J. Immunol. 135.4215.
24. Gilmore, G. L, J-Q. Yang, K B. Marcu, and B. K. Birshtein. 1987. Absence of somatic mutation in the variable region of MPC 11 variants expressing a different heavy chain isotype. J Immunol. 139:619.
25. H genes in two mouse strains. Proc. Natl. Acad. Sci. USA 81:2167.
26. Bothwell, A L. 1984. The genes encoding anti-NP antibodies in inbred strains of mice. In The Biology of Idiotypes M. I. Greene and A. Nissonoff, eds. Plenum Publishing Corp., New York, p. 19.
27. H gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of antibody Cell 25:59.
28. Perlmutter, R., S. Crews, R. Douglas, G. Sorensen, N. Johnson, N Nivera, P Gearhart, and L. Hood. 1984. The generation of diversity in phosphorylcholine-binding antibodies. Adv Immunol. 35:1.
29. H gene family In Evolution and Vertebrate Immunity, G. Kelsoe and D. H. Schulze, eds. The University of Texas Press, Houston, TX, p. 147.
30. H genes in CBA/J mice J. Exp. Med. 168:1339.
31. Koizumi, T., A. Puccetti, P. Migliorini, K. J. Barrett, and R. S. Schwartz. 1991. Molecular heterogeneity of auto-idiotypic antibodies in MRL-lpr/lpr mice. Eur. J. Immunol 21.2185.
32. Kofler, R., R M Perlmutter, D. J. Noonan, F. J. Dixon, amd A. N. Theofilopoulos. 1985. Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism J. Exp. Med. 162:346.
33. Manser, T. 1987. The generation and utilization of antibody variable region diversity In Molecular Genetics of Immunoglobulin. F Calabi and M. S. Neuberger, eds. Elsevier, Amsterdam, p. 177.
34. H7183 gene families in the NFS/N mouse. J. Immunol. 142:4483.
35. H gene family: identification of immunoglobulin gene promoter homologies J. Immunol. 138:4466
36. H locus EMBO J. 7:727
37. Matsuda, F., E. K. Shin, N. Nagaoka, R. Matsumura, M. Haino, Y. Fukita, S. Taka-ishi, Y. Imai, J. H. Riley, R. Anand, E. Soeda, and T. Honjo 1993 Structure and physical map of 64 variable segments in the 3′ 0.8 megabase region of the human immunoglobulin heavy chain locus. Nature Genet 3:88.
38. H locus completed by analysis of the telomeric region of chromosome 14q. Nature Genet 7:162
39. Walter, M. A., H. M. Dosch, and D W Cox. 1991. A deletion map of the human immunoglobulin heavy chain variable region J. Exp Med. 1174:335.
40. H locus. Eur. J. Immunol. 23.832.
41. Kaartinen, M., M-L. Solin, and O. Makelä. 1991 V genes of oxazolone antibodies in 10 strains of mice. Eur. J Immunol. 21:2863
42. H family members: usage is not position dependent. Int. Immunol. 5.1577.
43. H gene segments in pre-B-cell lines. Nature 311:727.
44. H genes. Science 227:1597.
45. Storb, U., D. Haasch, B. Arp, P. Sanchez, P.-A Cazenave, and J. Miller. 1989. Physical linkage of mouse λ genes by pulse-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences. Mol Cell Biol. 9:711.
46. α gene location J. Immunol. 147:1075.
47. Costa, T. E F., H. Suh, and M. C. Nussenzweig. 1992. Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice Proc Natl. Acad. Sci USA 89:2205.
48. Hesse, J. E, M R Lieber, K Mizuuchi, and M Gellen. 1989 V(D)J recombination a functional definition of the joining signals. Genes Dev. 3 1053.