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Redolfi S, Corda L, La Piana G, et al. Long-term noninvasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome. Respir Med 2007; 101:1191-1195. This pilot study found lower leptin levels in OHS patients without OSA syndrome than in eucapnic obese patients without OSA syndrome. This is in contrast to the findings of previous studies conducted in obese patients with sleep disordered breathing, in whom leptin levels were found to be increased. In this subgroup of OHS patients, leptin increased following normalization of diurnal blood gases with nocturnal ventilation.
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Lee S-D, Nakano H, Farkas GA. Adenosinergic modulation of ventilation in obese Zucker rats. Obes Res 2005; 13:545-555.
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Evidence from this study conducted in obese Zucker rats raises the possibility that the GABAergic system may play a role in the impairment of ventilatory control in obesity
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B receptors differentially modulate volume and frequency in ventilatory compensation in obese Zucker rats. J Appl Physiol 2007; 102:350-357. Evidence from this study conducted in obese Zucker rats raises the possibility that the GABAergic system may play a role in the impairment of ventilatory control in obesity.
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