GABAA and GABAB receptors differentially modulate volume and frequency in ventilatory compensation in obese Zucker rats

Journal of Applied Physiology

Volumn 102, Issue 1, 2007, Pages 350-357

  Yang, Ai Lun ^a   Lo, Ming Jae ^b   Ting, Hua ^c   Chen, Jwo Sheng ^d   Huang, Chih Yang ^d   Lee, Shin Da ^d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL TAICHUNG UNIVERSITY OF EDUCATION   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bicuculline; Gamma aminobutyric acid; Hypoxia; Phaclofen; Respiration

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; BICUCULLINE; DIMETHYL SULFOXIDE; PHACLOFEN;

AEROBIC EXERCISE; AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING RATE; CONTROLLED STUDY; HYPERCAPNIA; HYPOXIA; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TIDAL VOLUME; TREADMILL EXERCISE;

ANIMALS; ANOXIA; BACLOFEN; BICUCULLINE; DIMETHYL SULFOXIDE; GABA ANTAGONISTS; HYPERCAPNIA; MALE; OBESITY; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; PULMONARY VENTILATION; RATS; RATS, ZUCKER; RECEPTORS, GABA-A; RECEPTORS, GABA-B; RESPIRATORY MECHANICS; TIDAL VOLUME;

EID: 33846147031     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01463.2005     Document Type: Article

References (39)

1. Abdelmalki A, Merino D, Bonneau D, Bigard AX, Guezennec CY. Administration of a GABAB agonist baclofen before running to exhaustion in the rat: effects on performance and on some indicators of fatigue. Int J Sports Med 18: 75-78, 1997.
2. Abellan MT, Jolas T, Aghajanian GK, Artigas F. Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies. Synapse 36: 21-34, 2000.
3. Babb TG. Mechanical ventilatory constraints in aging, lung disease, and obesity: perspectives and brief review. Med Sci Sports Exerc 31: S12-S22, 1999.
4. Boutin P, Dina C, Vasseur F, Dubois S, Corset L, Seron K, Bekris L, Cabellon J, Neve B, Vasseur-Delannoy V, Chikri M, Charles MA, Clement K, Lernmark A, Froguel P. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol 1: E68, 2003.
5. Chaouloff F, Kennett GA, Serrurrier B, Merino D, Curzon G. Amino acid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in the rat. J Neurochem 46: 1647-1650, 1986.
6. Chebib M, Johnston GA. The 'ABC' of GABA receptors: a brief review. Clin Exp Pharmacol Physiol 26: 937-940, 1999.
7. Coscina DV, Castonguay TW, Stern JS. Effects of increasing brain GABA on the meal patterns of genetically obese vs. lean Zucker rats. Int J Obes Relat Metab Disord 16: 425-433, 1992.
8. Dempsey JA, Reddan W, Rankin J, Balke B. Alveolar-arterial gas exchange during muscular work in obesity. J Appl Physiol 21: 1807-1814, 1966.
9. Drorbaugh JE, Fenn WO. A barometric method for measuring ventilation in newborn infants. Pediatrics 16: 81-87, 1955.
10. Farkas GA, Schlenker EH. Pulmonary ventilation and mechanics in morbidly obese Zucker rats. Am J Respir Crit Care Med 150: 356-362, 1994.
11. Gozal D, Gozal E, Simakajornboon N. Signaling pathways of the acute hypoxic ventilatory response in the nucleus tractus solitarius. Respir Physiol 121: 209-221, 2000.
12. Hayashi F, Lipski J. The role of inhibitory amino acids in control of respiratory motor output in an arterially perfused rat. Respir Physiol 89: 47-63, 1992.
13. Hedner J, Hedner T, Wessberg P, Jonason J. An analysis of the mechanism by which gamma-aminobutyric acid depresses ventilation in the rat. J Appl Physiol 56: 849-856, 1984.
14. Holtman JR, King KA. Regulation of respiratory motor outflow to the larynx and diaphragm by GABA receptors. Eur J Pharmacol 156: 181-187, 1988.
15. Hoop B, Shih VE, Kazemi H. Relationship between central nervous system hydrogen ion regulation and amino acid metabolism in hypercapnia. II. Am Rev Respir Dis 132: 248-253, 1985.
16. Jacky JP. Barometric measurement of tidal volume: effects of pattern and nasal temperature. J Appl Physiol 49: 319-325, 1980.
17. Kazemi H, Hoop B. Glutamic acid and gamma-aminobutyric acid neurotransmitters in central control of breathing. J Appl Physiol 70: 1-7, 1991.
18. Kneussl MP, Pappagianopoulos P, Hoop B, Kazemi H. Reversible depression of ventilation and cardiovascular function by ventriculocisternal perfusion with gamma-aminobutyric acid in dogs. Am Rev Respir Dis 133: 1024-1028, 1986.
19. Lee SD, Magalang UJ, Krasney JA, Farkas GA. Opioidergic modulation of ventilatory response to sustained hypoxia in obese Zucker rats. Obes Res 9: 407-413, 2001.
20. Lee SD, Nakano H, Farkas GA. Adenosinergic modulation of ventilation in obese Zucker rats. Obes Res 13: 545-555, 2005.
21. Lee SD, Nakano H, Farkas GA. GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats. J Appl Physiol 90: 1707-1713, 2001.
22. Lee SD, Nakano H, Farkas GA. NMDA receptor-mediated modulation of ventilation in obese Zucker rats. Int J Obes Relat Metab Disord 25: 997-1004, 2001.
23. Lee SD, Nakano H, Gosselin LE, Krasney JA, Schlenker EH, Farkas GA. Endogenous opioids modulate ventilation and peak oxygen consumption in obese Zucker rats. Am J Respir Crit Care Med 162: 1009-1015, 2000.
24. Lin TB, Lo MJ, Huang CY, Ting H, Lee SD. GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. Int J Obes (Lond) 29: 188-195, 2005.
25. Meeusen R, Smolders I, Sarre S, de Meirleir K, Keizer H, Serneels M, Ebinger G, Michotte Y. Endurance training effects on neurotransmitter release in rat striatum: an in vivo microdialysis study. Acta Physiol Scand 159: 335-341, 1997.
26. Melton JE, Neubauer JA, Edelman NH. GABA antagonism reverses hypoxic respiratory depression in the cat. J Appl Physiol 69: 1296-1301, 1990.
27. Morgan EJ, Zwillich CW. The obesity-hypoventilation syndrome. West J Med 129: 387-393, 1978.
28. Nakano H, Lee SD, Farkas GA. Dopaminergic modulation of ventilation in obese Zucker rats. J Appl Physiol 92: 25-32, 2002.
29. Nakano H, Lee SD, Ray AD, Krasney JA, Farkas GA. Role of nitric oxide in thermoregulation and hypoxic ventilatory response in obese Zucker rats. Am J Respir Crit Care Med 164: 437-442, 2001.
30. Nakano H, Magalang UJ, Lee SD, Krasney JA, Farkas GA. Serotonergic modulation of ventilation and upper airway stability in obese Zucker rats. Am J Respir Crit Care Med 163: 1191-1197, 2001.
31. Orosco M, Jacquot C, Wepierre J, Cohen Y. GABA levels and synthesis index in different brain areas of two obese rat models. Gen Pharmacol 12: 369-371, 1981.
32. Overton JM, Redding MW, Yancey SL, Stremel RW. Hypothalamic GABAergic influences on treadmill exercise responses in rats. Brain Res Bull 33: 517-522, 1994.
33. Pierrefiche O, Foutz AS, Denavit-Saubie M. Effects of GABAB receptor agonists and antagonists on the bulbar respiratory network in cat. Brain Res 605: 77-84, 1993.
34. Refinetti R. Computation of the effective body mass for metabolic studies of lean and obese rats. Metabolism 38: 763-766, 1989. [Corrigenda. Metabolism 39: February 1990, p. 215.]
35. Rosmond R, Bouchard C, Bjorntorp P. Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion. Int J Obes Relat Metab Disord 26: 938-941, 2002.
36. Suzuki M, Tetsuka M, Endo M. GABA(B) receptors in the nucleus tractus solitarii modulate the carotid chemoreceptor reflex in rats. Neurosci Lett 260: 21-24, 1999.
37. Teichtahl H. The obesity-hypoventilation syndrome revisited. Chest 120: 336-339, 2001.
38. Wong CG, Bottiglieri T, Snead OC 3rd. GABA, gamma-hydroxybutyric acid, and neurological disease. Ann Neurol 54, Suppl 6: S3-S12, 2003.
39. Wood JD, Watson WJ, Ducker AJ. The effect of hypoxia on brain gamma-aminobutyric acid levels. J Neurochem 15: 603-608, 1968.