-
1
-
-
0347694971
-
On the nature of the multivalency effect: A thermodynamic model
-
Kitov PI, Bundle DR. On the nature of the multivalency effect: a thermodynamic model. J. Am. Chem. Soc. 2003; 125: 16271-16284.
-
(2003)
J. Am. Chem. Soc
, vol.125
, pp. 16271-16284
-
-
Kitov, P.I.1
Bundle, D.R.2
-
2
-
-
0031049701
-
Peptabody: A new type of high avidity binding protein
-
Terskikh AV, Le Doussal JM, Crameri R, Fisch I, Mach JP, Kajava AV. "Peptabody": a new type of high avidity binding protein. Proc. Natl. Acad. Sci. U.S.A. 1997; 94: 1663-1668.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A
, vol.94
, pp. 1663-1668
-
-
Terskikh, A.V.1
Le Doussal, J.M.2
Crameri, R.3
Fisch, I.4
Mach, J.P.5
Kajava, A.V.6
-
3
-
-
0032531947
-
Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
-
Kramer RH, Karpen JW. Spanning binding sites on allosteric proteins with polymer-linked ligand dimers. Nature 1998; 395: 710-713.
-
(1998)
Nature
, vol.395
, pp. 710-713
-
-
Kramer, R.H.1
Karpen, J.W.2
-
4
-
-
0034728565
-
Design, synthesis, and characterization of a high-affinity trivalent system derived from vancomycin and L-Lys-D-Ala-D-Ala
-
Rao J, Lahiri J, Weis RM, Whitesides GM. Design, synthesis, and characterization of a high-affinity trivalent system derived from vancomycin and L-Lys-D-Ala-D-Ala. J. Am Chem. Soc. 2000; 122: 2698-2710.
-
(2000)
J. Am Chem. Soc
, vol.122
, pp. 2698-2710
-
-
Rao, J.1
Lahiri, J.2
Weis, R.M.3
Whitesides, G.M.4
-
5
-
-
0030773876
-
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
-
Cwirla SE, Balasubramanian P, Duffin DJ, Wagstrom CR, Gates CM, Singer SC, Davis AM, Tansik RL, Mattheakis LC, Boytos CM, Schatz PJ, Baccanari DP, Wrighton NC, Barrett RW, Dower WJ. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 1997; 276: 1696-1699.
-
(1997)
Science
, vol.276
, pp. 1696-1699
-
-
Cwirla, S.E.1
Balasubramanian, P.2
Duffin, D.J.3
Wagstrom, C.R.4
Gates, C.M.5
Singer, S.C.6
Davis, A.M.7
Tansik, R.L.8
Mattheakis, L.C.9
Boytos, C.M.10
Schatz, P.J.11
Baccanari, D.P.12
Wrighton, N.C.13
Barrett, R.W.14
Dower, W.J.15
-
6
-
-
13144252172
-
Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity
-
Johnson DL, Farrell FX, Barbone FP, McMahon FJ, Tullai J, Kroon D, Freedy J, Zivin RA, Mulcahy LS, Jolliffe LK. Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity. Chem. Biol. 1997; 4: 939-950.
-
(1997)
Chem. Biol
, vol.4
, pp. 939-950
-
-
Johnson, D.L.1
Farrell, F.X.2
Barbone, F.P.3
McMahon, F.J.4
Tullai, J.5
Kroon, D.6
Freedy, J.7
Zivin, R.A.8
Mulcahy, L.S.9
Jolliffe, L.K.10
-
7
-
-
0026019106
-
Erythropoietin
-
Krantz SB. Erythropoietin. Blood 1991; 77: 419-434.
-
(1991)
Blood
, vol.77
, pp. 419-434
-
-
Krantz, S.B.1
-
8
-
-
33645334937
-
Cancer-related anemia and recombinant human erythropoietin-an updated overview
-
Bohlius J, Weingart O, Trelle S, Engert A. Cancer-related anemia and recombinant human erythropoietin-an updated overview. Nat. Clin. Pract. Oncol. 2006; 3: 152-164.
-
(2006)
Nat. Clin. Pract. Oncol
, vol.3
, pp. 152-164
-
-
Bohlius, J.1
Weingart, O.2
Trelle, S.3
Engert, A.4
-
9
-
-
0037384789
-
Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin
-
Egrie JC, Dwyer E, Browne JK, Hitz A, Lykos MA. Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. Exp. Hematol. 2003; 31: 290-299.
-
(2003)
Exp. Hematol
, vol.31
, pp. 290-299
-
-
Egrie, J.C.1
Dwyer, E.2
Browne, J.K.3
Hitz, A.4
Lykos, M.A.5
-
10
-
-
33646680103
-
Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity
-
Long DL, Doherty DH, Eisenberg SP, Smith DJ, Rosendahl MS, Christensen KR, Edwards DP, Chlipala EA, Cox GN. Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity. Exp. Hematol. 2006; 34: 697-704.
-
(2006)
Exp. Hematol
, vol.34
, pp. 697-704
-
-
Long, D.L.1
Doherty, D.H.2
Eisenberg, S.P.3
Smith, D.J.4
Rosendahl, M.S.5
Christensen, K.R.6
Edwards, D.P.7
Chlipala, E.A.8
Cox, G.N.9
-
11
-
-
0037423148
-
Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein
-
Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Wilken J, Tang J, Levy JJ, Miranda LP, Crnogorac MM, Kalbag S, Botti P, Schindler-Horvat J, Savatski L, Adamson JW, Kung A, Kent SB, Bradburne JA. Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science 2003; 299: 884-887.
-
(2003)
Science
, vol.299
, pp. 884-887
-
-
Kochendoerfer, G.G.1
Chen, S.Y.2
Mao, F.3
Cressman, S.4
Traviglia, S.5
Shao, H.6
Hunter, C.L.7
Low, D.W.8
Cagle, E.N.9
Carnevali, M.10
Gueriguian, V.11
Keogh, P.J.12
Porter, H.13
Stratton, S.M.14
Wiedeke, M.C.15
Wilken, J.16
Tang, J.17
Levy, J.J.18
Miranda, L.P.19
Crnogorac, M.M.20
Kalbag, S.21
Botti, P.22
Schindler-Horvat, J.23
Savatski, L.24
Adamson, J.W.25
Kung, A.26
Kent, S.B.27
Bradburne, J.A.28
more..
-
12
-
-
0033548259
-
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
-
Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK, Wilson IA. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 1999; 283: 987-990.
-
(1999)
Science
, vol.283
, pp. 987-990
-
-
Livnah, O.1
Stura, E.A.2
Middleton, S.A.3
Johnson, D.L.4
Jolliffe, L.K.5
Wilson, I.A.6
-
13
-
-
0033594965
-
Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site
-
Naranda T, Wong K, Kaufman RI, Goldstein A, Olsson L. Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site. Proc. Natl. Acad. Sci. U.S.A. 1999; 96: 7569-7574.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 7569-7574
-
-
Naranda, T.1
Wong, K.2
Kaufman, R.I.3
Goldstein, A.4
Olsson, L.5
-
14
-
-
0033609857
-
An erythropoietin fusion protein comprised of identical repeating domains exhibits enhanced biological properties
-
Sytkowski AJ, Lunn ED, Risinger MA, Davis KL. An erythropoietin fusion protein comprised of identical repeating domains exhibits enhanced biological properties. J. Biol. Chem. 1999; 274: 24773-24778.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 24773-24778
-
-
Sytkowski, A.J.1
Lunn, E.D.2
Risinger, M.A.3
Davis, K.L.4
-
15
-
-
0032477808
-
Human erythropoietin dimers with markedly enhanced in vivo activity
-
Sytkowski AJ, Lunn ED, Davis KL, Feldman L, Siekman S. Human erythropoietin dimers with markedly enhanced in vivo activity. Proc. Natl. Acad. Sci. U.S.A. 1998; 95: 1184-1188.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A
, vol.95
, pp. 1184-1188
-
-
Sytkowski, A.J.1
Lunn, E.D.2
Davis, K.L.3
Feldman, L.4
Siekman, S.5
-
16
-
-
0035877998
-
Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivo
-
Dalle B, Henri A, Rouyer-Fessard P, Bettan M, Scherman D, Beuzard Y, Payen E. Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivo. Blood 2001; 97: 3776-3782.
-
(2001)
Blood
, vol.97
, pp. 3776-3782
-
-
Dalle, B.1
Henri, A.2
Rouyer-Fessard, P.3
Bettan, M.4
Scherman, D.5
Beuzard, Y.6
Payen, E.7
-
17
-
-
0033523259
-
Stepwise solid-phase synthesis of polyamides as linkers
-
Rose K, Vizzavona J. Stepwise solid-phase synthesis of polyamides as linkers. J. Am. Chem. Soc. 1999; 121: 7034-7038.
-
(1999)
J. Am. Chem. Soc
, vol.121
, pp. 7034-7038
-
-
Rose, K.1
Vizzavona, J.2
-
18
-
-
33646118735
-
Multivalent fertilinbeta oligopeptides: The dependence of fertilization inhibition on length and density
-
Baessler KA, Lee Y, Roberts KS, Facompre N, Sampson NS. Multivalent fertilinbeta oligopeptides: the dependence of fertilization inhibition on length and density. Chem Biol. 2006; 13: 251-259.
-
(2006)
Chem Biol
, vol.13
, pp. 251-259
-
-
Baessler, K.A.1
Lee, Y.2
Roberts, K.S.3
Facompre, N.4
Sampson, N.S.5
-
19
-
-
0030670682
-
Solid phase peptide synthesis
-
Fields G. Solid phase peptide synthesis. Methods Enzymol. 1997; 289: 3-392.
-
(1997)
Methods Enzymol
, vol.289
, pp. 3-392
-
-
Fields, G.1
-
20
-
-
0026486811
-
In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences
-
Schnolzer M, Alewood P, Jones A, Alewood D, Kent SB. In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences. Int. J. Pept. Protein Res. 1992; 40: 180-193.
-
(1992)
Int. J. Pept. Protein Res
, vol.40
, pp. 180-193
-
-
Schnolzer, M.1
Alewood, P.2
Jones, A.3
Alewood, D.4
Kent, S.B.5
-
21
-
-
0028231302
-
Facile synthesis of homogeneous artificial proteins
-
Rose K. Facile synthesis of homogeneous artificial proteins. J. Am. Chem. Soc. 1994; 116: 30-33.
-
(1994)
J. Am. Chem. Soc
, vol.116
, pp. 30-33
-
-
Rose, K.1
-
22
-
-
0014772602
-
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
-
Kaiser E, Colescott RL, Bossinger CD, Cook PI. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal. Biochem. 1970; 34: 595-598.
-
(1970)
Anal. Biochem
, vol.34
, pp. 595-598
-
-
Kaiser, E.1
Colescott, R.L.2
Bossinger, C.D.3
Cook, P.I.4
-
23
-
-
0030059104
-
Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins
-
Gaertner HF, Offord RE. Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins. Bioconjugate Chem. 1996; 7: 38-44.
-
(1996)
Bioconjugate Chem
, vol.7
, pp. 38-44
-
-
Gaertner, H.F.1
Offord, R.E.2
-
24
-
-
0026857064
-
Construction of protein analogues by site-specific condensation of unprotected fragments
-
Gaertner HF, Rose K, Cotton R, Timms D, Camble R, Offord RE. Construction of protein analogues by site-specific condensation of unprotected fragments. Bioconjugate Chem. 1992; 3: 262-268.
-
(1992)
Bioconjugate Chem
, vol.3
, pp. 262-268
-
-
Gaertner, H.F.1
Rose, K.2
Cotton, R.3
Timms, D.4
Camble, R.5
Offord, R.E.6
-
25
-
-
0026826660
-
Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine
-
Kieran FG, Stroh JG. Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine. Bioconjugate Chem. 1992; 3: 138-146.
-
(1992)
Bioconjugate Chem
, vol.3
, pp. 138-146
-
-
Kieran, F.G.1
Stroh, J.G.2
-
26
-
-
18344377339
-
Activation of erythropoietin receptor through a novel extracellular binding site
-
Naranda T, Kaufman RI, Li J, Wong K, Boge A, Hallen D, Fung KY, Duncan MW, Andersen N, Goldstein A, Olsson L. Activation of erythropoietin receptor through a novel extracellular binding site. Endocrinology 2002; 143: 2293-2302.
-
(2002)
Endocrinology
, vol.143
, pp. 2293-2302
-
-
Naranda, T.1
Kaufman, R.I.2
Li, J.3
Wong, K.4
Boge, A.5
Hallen, D.6
Fung, K.Y.7
Duncan, M.W.8
Andersen, N.9
Goldstein, A.10
Olsson, L.11
-
27
-
-
0029798402
-
Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 A
-
Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, Wilson IA. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science 1996; 273: 464-471.
-
(1996)
Science
, vol.273
, pp. 464-471
-
-
Livnah, O.1
Stura, E.A.2
Johnson, D.L.3
Middleton, S.A.4
Mulcahy, L.S.5
Wrighton, N.C.6
Dower, W.J.7
Jolliffe, L.K.8
Wilson, I.A.9
-
28
-
-
0035168781
-
A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types
-
Nardin EH, Calvo-Calle JM, Oliveira GA, Nussenzweig RS, Schneider M, Tiercy JM, Loutan L, Hochstrasser D, Rose K. A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types. J. Immunol. 2001; 166: 481-489.
-
(2001)
J. Immunol
, vol.166
, pp. 481-489
-
-
Nardin, E.H.1
Calvo-Calle, J.M.2
Oliveira, G.A.3
Nussenzweig, R.S.4
Schneider, M.5
Tiercy, J.M.6
Loutan, L.7
Hochstrasser, D.8
Rose, K.9
-
29
-
-
0035898952
-
Assembly of synthetic peptide vaccines by chemoselective ligation of epitopes: Influence of different chemical linkages and epitope orientations on biological activity
-
Zeng W, Ghosh S, Macris M, Pagnon J, Jackson DC. Assembly of synthetic peptide vaccines by chemoselective ligation of epitopes: influence of different chemical linkages and epitope orientations on biological activity. Vaccine 2001; 19: 3843-3852.
-
(2001)
Vaccine
, vol.19
, pp. 3843-3852
-
-
Zeng, W.1
Ghosh, S.2
Macris, M.3
Pagnon, J.4
Jackson, D.C.5
|