Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway

Genes and Development

Volumn 12, Issue 20, 1998, Pages 3252-3263

  Harrison, Douglas A ^a,c   McCoon, Patricia E ^d   Binari, Richard ^a,e   Gilman, Michael ^d   Perrimon, Norbert ^a,b  

^a Department of Genetics ^*  (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d ARIAD PHARMACEUTICALS INC   (United States)

^e PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Hopscotch; JAK; Ligand; Segmentation

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; GLYCOPROTEIN; GROWTH FACTOR; PROTEIN TYROSINE KINASE; RNA;

ANIMAL CELL; ARTICLE; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALIA; VERTEBRATA;

EID: 0032532120     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.20.3252     Document Type: Article

References (54)

1. Ashburner, M. 1989. Drosophila: A laboratory manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. Baumgartner, S., D. Martin, C. Hagios, and R. Chiquet-Ehrismann. 1994. Tenm, a Drosophila gene related to tenascin, is a new pair-rule gene. EMBO J. 13: 3728-3740.
3. Binari, R. and N. Perrimon. 1994. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes &. Dev. 8: 300-312.
4. Bradley, R.S. and A.M. Brown. 1990. The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. EMBO J. 9: 1569-1575.
5. Brown, N.H. and F.C. Kafatos. 1988. Functional cDNA libraries from Drosophila embryos. J. Mol. Biol. 203: 425-437.
6. Casanova, J. and G. Struhl. 1993. The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila. Nature 362: 152-155.
7. Darnell, J.E. Jr. 1997. STATs and gene regulation. Science 277: 1630-1635.
8. Di Nocera, P.P. and I.E. Dawid. 1983. Transient expression of genes introduced into cultured cells of Drosophila. Proc. Natl. Acad. Sci. 80: 7095-7098.
9. Durbin, J.E., R. Hackenmiller, M.C. Simon, and D.E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450.
10. Eberl, D., L. Perkins, M. Engelstein, A. Hilliker, and N. Perrimon. 1992. Genetic and developmental analysis of polytene section 17 of the X chromosome of Drosophila melanogaster. Genetics 130: 569-583.
11. Ferrus, A., S. Llamazares, J.L. de la Pompa, M.A. Tanouye, and O. Pongs. 1990. Genetic analysis of the Shaker gene complex of Drosophila melanogaster. Genetics 125: 383-398.
12. Gergen, P. and E. Wieschaus. 1986. Localized requirements for gene activity in segmentation of Drosophila embryos: Analysis of armadillo, fused, giant and unpaired mutations in mosaic embryos. Wilhelm Roux's Arch. Dev. Biol. 195: 49-62.
13. Goto, T., P. Macdonald, and T. Maniatis. 1989. Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues. Cell 57: 413-422.
14. Harrison, D., R. Binari, T. Nahreini, M. Gilman, and N. Perrimon. 1995. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14: 2857-2865.
15. Hou, X.S. and N. Perrimon. 1997. The JAK-STAT pathway in Drosophila. Trends Genet. 13:105-110.
16. Hou, X.S., M.B. Melnick, and N. Perrimon. 1996. marelle acts downstream of the Drosophila Hop/Jak kinase and encodes a protein similar to the mammalian Stats. Cell 84: 411-419.
17. Ihle, J.N. 1996. STATs: Signal transducers and activators of transcription. Cell 84: 331-334.
18. Ihle, J.N., T. Nosaka, W. Thierfelder, F.W. Quelle, and K. Shimoda. 1997. Jaks and Stats in cytokine signaling. Stem Cells 15: 105-111.
19. Ingham, P.W. 1988. The molecular genetics of embryonic pattern formation in Drosophila. Nature 335: 25-34.
20. Juni, N., T. Awasaki, K. Yoshida, and S.H. Hori. 1996. The Om(1E) mutation in Drosophila ananassae causes compound eye overgrowth due to tom retrotransposon-driven overexpression of a novel gene. Genetics 143: 1257-1270.
21. Kadowaki, T., E. Wilder, J. Klingensmith, K. Zachary, and N. Perrimon. 1996. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes & Dev. 10: 3116-3128.
22. Kilchherr, F., S. Baumgartner, D. Bopp, E. Frei, and M. Noll. 1986. Isolation of the paired gene of Drosophila and its spatial expression during early embryogenesis. Nature 321: 493-499.
23. Krah-Jentgens, I. 1989. "Klonierung des Shaker-Komplexes von Drosophila melanogaster und Charakterisierung einer Transkriptionseinheit aus diesem Gen-Komplex." Ph.D. Thesis, Ruhr-Universitat Bochum, Hamburg, Germany.
24. Lacronique, V., A. Boureux, V.D. Valle, H. Poirel, C.T. Quang, M. Mauchauffe, C. Berthou, M. Lessard, R. Berger, J. Ghysdael, and O.A. Bernard. 1997. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278: 1309-1312.
25. Lindsley, D. and G. Zimm. 1992. The genome of Drosophila melanogaster Academic Press, San Diego, CA.
26. Tum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 14:1412-1420.
27. Macchi, P., A. Villa, S. Gillani, M.G. Sacco, A. Frattini, F. Porta, A.G. Ugazio, J.A. Johnston, F. Candotti, J.J. O Shea, P. Vezzoni, and L.D. Notarangelo. 1995. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377: 65-68.
28. Macdonald, P., P. Ingham, and G. Struhl. 1986. Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo box. Cell 47: 721-734.
29. Meraz, M.A., J.M. White, K.C. Sheehan, E.A. Bach, S.J. Rodig, A.S. Dighe, D.H. Kaplan, J.K. Riley, A.C. Greenlund, D. Campbell, K. Carver-Moore, R.N. DuBois, R. Clark, M. Aguet, and R.D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84: 431-442.
30. Natesan, S. and M. Gilman. 1995. YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol. Cell. Biol. 15: 5975-5982.
31. Natesan, S., V.M. Rivera, E. Molinari, and M. Gilman. 1997. Transcriptional squelching re-examined. Nature 390: 349-350.
32. Neubauer, H., A. Cumano, M. Muller, H. Wu, U. Huffstadt, and K. Pfeffer. 1998. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93: 397-409.
33. Nosaka, T., J.M. van Deursen, R.A. Tripp, W.E. Thierfelder, B.A. Witthuhn, A.P. McMickle, P.C. Doherty, G.C. Grosveld, and J.N. Ihle. 1995. Defective lymphoid development in mice lacking Jak3. Science 270: 800-802.
34. Nüsslein-Volhard, C. and E. Weischaus. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287: 795-801.
35. Parganas, E., D. Wang, D. Stravopodis, D.J. Topham, J.C. Marine, S. Teglund, E.F. Vanin, S. Bodner, O.R. Colamonici, J.M. van Deursen, G. Grosveld, and J.N. Ihle. 1998. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93: 385-395.
36. Peel, D. and M. Milner. 1992. The expression of PS integrins in Drosophila melanogaster imaginai disc cell lines. Wilhelm Roux's Arch. Dev. Biol. 201: 120-123.
37. Peeters, P., S.D. Raynaud, J. Cools, I. Wlodarska, J. Grosgeorge, P. Philip, F. Monpoux, L. Van Rompaey, M. Baens, H. Van den Berghe, and P. Marynen. 1997. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90: 2535-2540.
38. Perrimon, N. and A. Mahowald. 1986. 1(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. Dev. Biol. 118:28-41.
39. Riedl, A. and M. Jacobs-Lorena. 1996. Determinants of Drosophila fushi tarazu mRNA instability. Mol. Cell. Biol. 16: 3047-3053.
40. Rodig, S.J., M.A. Meraz, J.M. White, P.A. Lampe, J.K. Riley, C.D. Arthur, K.L. King, K.C. Sheehan, L. Yin, D. Pennica, E.M. Johnson Jr., and R.D. Schreiber. 1998. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93: 373-383.
41. Rottier, P.J., R.Z. Florkiewicz, A.S. Shaw, and J.K. Rose. 1987. An internalized amino-terminal signal sequence retains full activity in vivo but not in vitro. J. Biol. Chem. 262: 8889-8895.
42. Shaw, G. and R. Kamen. 1986 . A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667.
43. Small, S., A. Blair, and M. Levine. 1996. Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. Dev. Biol. 175: 314-324.
44. Sprang, S.R. and J.F. Bazan. 1993. Cytokine structural taxonomy and mechanisms of receptor engagement. Curr. Opin. Struct. Biol. 3: 815-827.
45. St Johnston, D. and C. Nüsslein-Volhard. 1992. The origin of pattern and polarity in the Drosophila embryo. Cell 68: 201-219.
46. Stein, D. and C. Nüsslein-Volhard. 1992. Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity. Cell 68: 429-440.
47. Vignais, M.L., H.B. Sadowski, D. Watling, N.C. Rogers, and M. Gilman. 1996. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. 16: 1759-1769.
48. Wieschaus, E., C. Nüsslein-Volhard, and G. Jurgens. 1984. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. Part III. Zygotic loci on the X-chromosome and fourth chromosome. Wilhelm Roux's Arch. Dev. Biol. 193: 296-307.
49. Yamauchi, T., K. Ueki, K. Tobe, H. Tamemoto, N. Sekine, M. Wada, M. Honjo, M. Takahashi, T. Takahashi, H. Hirai, T. Tushima, Y. Akanuma, T. Fujita, I. Komuro, Y. Yazaki, and T. Kadowaki. 1997. Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature 390: 91-96.
50. Yan, R., H. Luo, J.E. Darnell Jr, and C.R. Dearolf. 1996a. A JAK-STAT pathway regulates wing vein formation in Drosophila. Proc. Natl. Acad. Sci. 93: 5842-5847.
51. Yan, R., S. Small, C. Desplan, C.R. Dearolf, and J.E. Darnell Jr. 1996b. Identification of a Stat gene that functions in Drosophila development. Cell 84: 421-430.
52. Zhang, F., M.B. Basinski, J.M. Beals, S.L. Briggs, L.M. Churgay, D.K. Clawson, R.D. DiMarchi, T.C. Furman, J.E. Hale, H.M. Hsiung, B.E. Schoner, D.P. Smith, X.Y. Zhang, J.P. Wery, and R.W. Schevitz. 1997. Crystal structure of the obese protein leptin-E100. Nature 387: 206-209.
53. Zinn, K., L. McAllister, and C.S. Goodman. 1988. Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila. Cell 53: 577-587.
54. Zong, C., R. Yan, A. August, J.E. Darnell, and H. Hanafusa. 1996. Unique signal transduction of Eyk: Constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J. 15: 4515-4525.