Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding

EMBO Journal

Volumn 17, Issue 12, 1998, Pages 3219-3232

  Schumacher, Maria A ^a,b   Carter, Darrick ^a   Scott, Daniel M ^a   Roos, David S ^c   Ullman, Buddy ^a   Brennan, Richard G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Crystallography; Structure based drug design; Toxoplasma gondii; Toxoplasmosis; Uracil phosphoribosyltransferase

Indexed keywords

ANTIPARASITIC AGENT; CYTOSINE; DIMER; FLUOROURACIL; PRODRUG; PYRIMIDINE; PYRIMIDINE DERIVATIVE; THYMINE; URACIL; URACIL PHOSPHORIBOSYLTRANSFERASE; URIDINE PHOSPHATE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; ANIMALS; ANTIMETABOLITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; FLUOROURACIL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PENTOSYLTRANSFERASES; PRODRUGS; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; PYRIMIDINES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TOXOPLASMA; URIDINE MONOPHOSPHATE;

PROTOZOA; TOXOPLASMA GONDII;

EID: 0032526987     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.12.3219     Document Type: Article

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