Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells

European Journal of Pharmacology

Volumn 573, Issue 1-3, 2007, Pages 49-54

  Chao, Hung Hsing ^a,b   Hong, Hong Jye ^c   Liu, Ju Chi ^a   Lin, Jia Wei ^a   Chen, Yen Ling ^a   Chiu, Wen Ta ^a   Wu, Chieh Hsi ^c   Shyu, Kou Gi ^a,b   Cheng, Tzu Hurng ^a,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Aortic smooth muscle cells; Endothelin 1; Epidermal growth factor receptor transactivation; Leptin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; HYPERTENSION; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSACTIVATION; WHITE ADIPOSE TISSUE;

ANIMALS; AORTA, THORACIC; BLOTTING, NORTHERN; BLOTTING, WESTERN; BUTADIENES; CELLS, CULTURED; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; LEPTIN; MALE; METALLOENDOPEPTIDASES; MYOCYTES, SMOOTH MUSCLE; NITRILES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TYROSINE; TYRPHOSTINS;

EID: 34648844228     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.051     Document Type: Article

References (20)

1. 2 and Src-dependent transactivation of the EGF receptor mediates the stimulatory effect of leptin on renal ERK and Na(+), K(+)-ATPase. Peptides 27 (2006) 3234-3244
2. Bouloumie A., Drexler H.C., Lafontan M., and Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res. 83 (1998) 1059-1066
3. Chen C.H., Cheng T.H., Lin H., Shih N.L., Chen Y.L., Chen Y.S., Cheng C.F., Lian W.S., Meng T.C., Chiu W.T., and Chen J.J. Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts. Mol. Pharmacol. 69 (2006) 1347-1355
4. Cheng T.H., Cheng P.Y., Shih N.L., Chen I.B., Wang D.L., and Chen J.J. Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts. J. Am. Coll. Cardiol. 42 (2003) 1845-1854
5. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334 (1996) 292-295
6. Ferri C., Bellini C., Desideri G., Di Francesco L., Baldoncini R., Santucci A., and De Mattia G. Plasma endothelin-1 levels in obese hypertensive and normotensive men. Diabetes 44 (1995) 431-436
7. Fitzgerald J.S., Busch S., Wengenmayer T., Foerster K., de la Motte T., Poehlmann T.G., and Markert U.R. Signal transduction in trophoblast invasion. Chem. Immunol. Allergy 88 (2005) 181-199
8. Madani S., De Girolamo S., Munoz D.M., Li R.K., and Sweeney G. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc. Res. 69 (2006) 716-725
9. Ogunwobi O., Mutungi G., and Beales I.L. Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Endocrinology 147 (2006) 4505-4516
10. Parhami F., Tintut Y., Ballard A., Fogelman A.M., and Demer L.L. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ. Res. 88 (2001) 954-960
11. Poirier P., Giles T.D., Bray G.A., Hong Y., Stern J.S., Pi-Sunyer F.X., and Eckel R.H. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 113 (2006) 898-918
12. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., and Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402 (1999) 884-888
13. Quehenberger P., Exner M., Sunder-Plassmann R., Ruzicka K., Bieglmayer C., Endler G., Muellner C., Speiser W., and Wagner O. Leptin induces endothelin-1 in endothelial cells in vitro. Circ. Res. 90 (2002) 711-718
14. Rajapurohitam V., Gan X.T., Kirshenbaum L.A., and Karmazyn M. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ. Res. 93 (2003) 277-279
15. Shek E.W., Brands M.W., and Hall J.E. Chronic leptin infusion increases arterial pressure. Hypertension 31 (1998) 409-414
16. Shida D., Kitayama J., Mori K., Watanabe T., and Nagawa H. Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells. Cancer Res. 65 (2005) 9159-9163
17. Shin H.J., Oh J., Kang S.M., Lee J.H., Shin M.J., Hwang K.C., Jang Y., and Chung J.H. Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 329 (2005) 18-24
18. Sweeney G. Leptin signalling. Cell Signal 14 (2002) 655-663
19. Takahashi K., Totsune K., Kikuchi K., and Murakami O. Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells. Hypertens. Res. 29 (2006) 443-448
20. Zeidan A., Purdham D.M., Rajapurohitam V., Javadov S., Chakrabarti S., and Karmazyn M. Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. J. Pharmacol. Exp. Ther. 315 (2005) 1075-1084