Osteotropic peptide that differentiates functional domains of the skeleton

Bioconjugate Chemistry

Volumn 18, Issue 5, 2007, Pages 1375-1378

  Wang, Dong ^a,b   Miller, Scott C ^d   Shlyakhtenko, Luda S ^a   Portillo, Alexander M ^a   Liu, Xin Ming ^a   Papangkorn, Kongnara ^b   Kopečková, Pavla ^b   Lyubchenko, Yuri ^a   Higuchi, William I ^b   Kopeček, Jindřich ^b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c Department of Electrical and Computer Engineering   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; APATITE; ATOMIC FORCE MICROSCOPY; BINDING SITES; BONE;

ALENDRONATE; BONE APATITE; CRISTALLINITY; FUNCTIONAL DOMAINS; HPMA COPOLYMERS; OCTAPEPTIDE; OVARIECTOMIZED RATS; RAT MODEL; SKELETAL TISSUES; SYSTEMIC ADMINISTRATION;

HYDROXYAPATITE;

ALENDRONIC ACID; ASPARTIC ACID DERIVATIVE; ASPARTYLASPARTYLASPARTYLASPARTYLASPARTYLASPARTYLASPARTYLASPARTIC ACID; BISPHOSPHONIC ACID DERIVATIVE; HYDROXYAPATITE; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; OCTAPEPTIDE; PEPTIDE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENAMEL; FEMALE; FEMUR; INCISOR; LUMBAR VERTEBRA; MANDIBLE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PROTEIN DOMAIN; RAT; TIBIA;

RATTUS;

EID: 34648825527     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc7002132     Document Type: Article

References (27)

1. Marks, S. C., Jr., and Odgren, P. R. (2002) Structure and development of the skeleton. In Principles of Bone Biology, 2nd ed. (Bilezikian, J. P., Raisz, L. G., and Rodan, G. A., Eds.) pp 3-15, Chapter 1, Volume 1, Academic Press, San Diego.
2. Rodan, G. A., and Martin, T. J. (2000) Therapeutic approaches to bone diseases. Science 289, 1508-1514.
3. Taylor, D., Hazenberg, J. G., and Lee, T. C. (2007) Living with cracks: Damage and repair in human bone. Nat. Mater. 6, 263-268.
4. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G. (1997) Osf2/Cbfal: A transcriptional activator of osteoblast differentiation. Cell 89, 747-754.
5. Takahashi, N., Udagawa, N., Takami, M., and Suda, T. (2002) Cells of bone: Osteoclast generation. In Principles of Bone Biology, 2nd ed. (Bilezikian, J. P., Raisz, L. G., and Rodan, G. A., Eds.) pp 109-126, Chapter 7, Volume 1, Academic Press, San Diego.
6. Väänänen, K., and Zhao, H. (2002) Osteoclast function: Biology and mechanisms. In Principles of Bone Biology, 2nd ed. (Bilezikian, J. P., Raisz, L. G., and Rodan, G. A. Eds.) pp 127-139, Chapter 8, Volume 1, Academic Press, San Diego.
7. Capparelli, C., Kostenuik, P. J., Morony, S., Starnes, C., Weimann, B., Van, G., Scully, S., Qi, M., Lacey, D. L., and Dunstan, C. R. (2000) Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy. Cancer Res. 60, 783-787.
8. Yamashita, D. S., and Dodds, R. A. (2000) Cathepsin K and the design of inhibitors of cathepsin K. Curr. Pharm. Des. 6, 1-24.
9. Minkin, C., and Jennings, J. M. (1972) Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture. Science 176, 1031-1033.
10. Engleman, V. W., Nickols, G. A., Ross, F. P., Horton, M. A., Griggs, D. W., Settle, S. L., Ruminski, P. G., and Teitelbaum, S. L. (1997) A peptidomimetic antagonist of the αvβ3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J. Clin. Invest. 99, 2284-2292.
11. Shakespeare, W., Yang, M., Bohacek, R., Cerasoli, F., Stebbins, K., Sundaramoorthi, R., Azimioara, M., Vu, C., Pradeepan, S., Metcalf, C., III, Haraldson, C., Merry, T., Dalgarno, D., Narula, S., Hatada, M., Lu, X., van Schravendijk, M. R., Adams, S., Violette, S., Smith, J., Guan, W., Bartlett, C., Herson, J., Iuliucci, J., Weigele, M., and Sawyer, T. (2000) Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc. Natl. Acad. Sci. U.S.A. 97, 9373-9378.
12. Miller, S. C., and Marks, S. C., Jr. (1994) Effects of prostaglandins on the skeleton. Clin. Plast. Surg. 21, 393-400.
13. Yoshida, K., Oida, H., Kobayashi, T., Maruyama, T., Tanaka, M., Katayama, T., Yamaguchi, K., Segi, E., Tsuboyama, T., Matsushita, M., Ito, K., Ito, Y., Sugimoto, Y., Ushikubi, F., Ohuchida, S., Kondo, K., Nakamura, T., and Narumiya, S. (2002) Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc. Natl. Acad. Sci. U.S.A. 99, 4580-4585.
14. Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., and Gutierrez, G. (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286, 1946-1949.
15. Lindsay, R., and Nieves, J. (1997) Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 350, 550-555.
16. Wang, D., Miller, S., Sima, M., Kopečková, P., and Kopeček, J. (2003) Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. Bioconjugate Chem. 14, 853-859.
17. Wang, D., Sima, M., Mosley, R. L., Davda, J. P., Tietze, N., Miller, S. C., Gwilt, P. R., Kopečková, P., and Kopeček, J. (2006) Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers. Mol. Pharm. 3, 717-725.
18. Frost, H. M., Villaneuva, A. R., and Roth, H. (1960) Measurement of bone formation in a 57 year old man by means of tetracyclines. Henry Ford Hosp. Med. Bull. 8, 239-254.
19. Posner, A. S., and Betts, F. (1975) Synthetic amorphous calcium phosphate and its relation to bone mineral structure. Acc. Chem. Res. 8, 273-281.
20. Posner, A. S. (1969) Crystal chemistry of bone mineral. Physiol. Rev. 49, 760-792.
21. Thompson, D. D., Posner, A. S., Laughlin, W. S., and Blumenthal, N. C. (1983) Comparison of bone apatite in osteoporotic and normal Eskimos. Calcif Tissue Int. 35, 392-393.
22. Limansky, A. P., Shlyakhtenko, L. S., Schaus, S., Henderson, E., and Lyubchenko, Y. L. (2002) Aminomodified probes for atomic force microscopy. Probe Microsc. 2, 227-234.
23. McAllister, C., Karymov, M. A., Kawano, Y., Lushnikov, A. Y., Mikheikin, A., Uversky, V. N., and Lyubchenko, Y. L. (2005) Protein interactions and misfolding analyzed by AFM force spectroscopy. J. Mol. Biol. 354, 1028-1042.
24. Shlyakhtenko, L. S., Gall, A. A., Filonov, A., Cerovac, Z., Lushnikov, A., and Lyubchenko, Y. L. (2003) Silatrane-based surface chemistry for immobilization of DNA, protein-DNA complexes and other biological materials. Ultramicroscopy 97, 279-287.
25. Nelson, D. G., and Featherstone, J. D. (1982) Preparation, analysis, and characterization of carbonated apatites. Calcif. Tissue Int. 34 Suppl. 2, S69-81.
26. Baig, A. A., Fox, J. L., Young, R. A., Wang, Z., Hsu, J., Higuchi, W. I., Chhettry, A., Zhuang, H., and Otsuka, M. (1999) Relationships among carbonated apatite solubility, crystallite size, and microstrain parameters. Calcif Tissue Int. 64, 437-449.
27. Markovic, M., Fowler, B. O., and Tung, M. S. (2004) Preparation and comprehensive characterization of a calcium hydroxyapatite reference material. J. Res. Natl. Inst. Stand. Technol. 109, 553-568.