A novel small molecule inhibitor targeted at Bcl-2

Science in China, Series C: Life Sciences

Volumn 50, Issue 5, 2007, Pages 624-629

  Jin, LiJi ^a   Zhang, ZhiChao ^a,b   Wang, YuanYuan ^a   Wei, MeiJiao ^a   Xu, Qin ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; Heterocyclic compound; Small molecule

Indexed keywords

8 OXO 3 THIOMORPHOLINO 8H ACENAPHTHO(1,2 B)PYRROLE 9 CARBONITRILE; 8-OXO-3-THIOMORPHOLINO-8H-ACENAPHTHO(1,2-B)PYRROLE-9-CARBONITRILE; ANTINEOPLASTIC AGENT; CASPASE 8; MORPHOLINE DERIVATIVE; NITRILE; PROTEIN BCL 2; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; APOPTOSIS; ARTICLE; CANCER TRANSPLANTATION; CELL MEMBRANE POTENTIAL; CELL STRAIN HL 60; CHEMICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; DRUG SCREENING; HUMAN; IC 50; METABOLISM; MITOCHONDRIAL MEMBRANE; MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; CIRCULAR DICHROISM; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIALS; MICE; MITOCHONDRIAL MEMBRANES; MODELS, CHEMICAL; MORPHOLINES; NEOPLASM TRANSPLANTATION; NITRILES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES;

EID: 34648819090     PISSN: 10069305     EISSN: 18622798     Source Type: Journal    
DOI: 10.1007/s11427-007-0079-0     Document Type: Article

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