Organometallic 99mTc(III) '4 + 1' bombesin(7-14) conjugates: Synthesis, radiolabeling, and in vitro/in vivo studies

Bioconjugate Chemistry

Volumn 18, Issue 5, 2007, Pages 1651-1661

  Kunstler, Jens Uwe ^a   Veerendra, Bhadrasetty ^b   Figueroa, Said D ^b   Sieckman, Gary L ^d   Rold, Tammy L ^b   Hoffman, Timothy J ^b,d   Smith, Charles J ^b,c,d   Pietzsch, Hans Jurgen ^a  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b University of Missouri   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BARIUM COMPOUNDS; BAYESIAN NETWORKS; BENZOIC ACID; CHELATION; COUPLING AGENTS; COUPLINGS; CYANIDES; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGANDS; ORGANOMETALLICS; PEPTIDES;

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; IN-VITRO; IN-VIVO; ISOCYANIDES; MONODENTATES; PEPTIDE RECEPTOR; RADIOLABELLING; SPACER GROUPS; TETRADENTATE; VIVO STUDIES;

MASS SPECTROMETRY;

2,2',2'' NITRILOTRIETHANETHIOL; 4 (ISOCYANOMETHYL)BENZOIC ACID; 4 ISOCYANOBUTANOIC ACID; BETA ALANINE; BOMBESIN DERIVATIVE; BOMBESIN[7-14]; CARBOXYLIC ACID; EDETIC ACID; GASTRIN RELEASING PEPTIDE RECEPTOR; MANNITOL; MONODENTATE ISOCYANIDE; ORGANOMETALLIC COMPOUND; RADIOACTIVE MATERIAL; RHENIUM; RHENIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 (ISOCYANOMETHYL)BENZOIC ACID BETA ALANINE BOMBESIN[7-14]; RHENIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 (ISOCYANOMETHYL)BENZOIC ACID GLYCYLGLYCYLGLYCINE BOMBESIN[7-14]; RHENIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 (ISOCYANOMETHYL)BENZOIC ACID SERYLSERYLSERINE BOMBESIN[7-14]; RHENIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 ISOCYANOBUTANOIC ACID BETA ALANINE BOMBESIN[7-14]; RHENIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 ISOCYANOBUTANOIC ACID GLYCYLGLYCYLGLYCINE BOMBESIN[7-14]; RHENIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 ISOCYANOBUTANOIC ACID SERYLSERYLSERINE BOMBESIN[7-14]; SERYLSERYLSERINE; TECHNETIUM (2,2',2'' NITRILOTRIETHANETHIOL CARBOXYLIC ACID 4 ISOCYANOBUTANOIC ACID BETA ALANINE BOMBESIN[7-14] TC 99M; TECHNETIUM (2,2',2'' NITRILOTRIETHANETHIOL CARBOXYLIC ACID) 4 (ISOCYANOMETHYL)BENZOIC ACID BETA ALANINE BOMBESIN[7-14] TC 99M; TECHNETIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 (ISOCYANOMETHYL)BENZOIC ACID BETA ALANINE BOMBESIN[7-14] TC 99M; TECHNETIUM (2,2',2'' NITRILOTRIETHANETHIOL) 4 ISOCYANOBUTANOIC ACID BETA ALANINE BOMBESIN[7-14] TC 99M; TECHNETIUM 99M; TETRADENTATE; TRIGLYCINE; TRIPEPTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BOMBESIN; CHELATING AGENT; CYANIDE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; LIGAND; PEPTIDE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM; TECHNETIUM COMPLEX;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; BINDING AFFINITY; BINDING ASSAY; CANCER CELL; CELL LINE; CELL SURFACE; CONJUGATE; CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; EXTERNALIZATION ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; LIGAND BINDING; LIPOPHILICITY; MOUSE; NONHUMAN; PANCREAS; PROSTATE CANCER; PROTEIN EXPRESSION; RADIOCHEMISTRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS; URINARY EXCRETION; ANIMAL; CELL CULTURE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; SCINTISCANNING; TIME; TISSUE DISTRIBUTION;

MUS; RODENTIA;

ANIMALS; BOMBESIN; CARBOXYLIC ACIDS; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYANIDES; ISOTOPE LABELING; LIGANDS; MALE; MICE; ORGANOTECHNETIUM COMPOUNDS; PEPTIDES; PROSTATIC NEOPLASMS; RADIOPHARMACEUTICALS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TECHNETIUM; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 34648816906     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc700197m     Document Type: Article

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