A role for neuropeptide Y in alcohol intake control: Evidence from human and animal research

Physiology and Behavior

Volumn 79, Issue 1, 2003, Pages 95-101

  Thiele, Todd E ^a   Badia Elder, Nancy E ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Alcoholism; Knockout; Neuropeptide Y; Selectively bred; Y1 receptor; Y2 receptor

Indexed keywords

ALCOHOL; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; PENTOBARBITAL; RECEPTOR SUBTYPE; SUCROSE;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; AMYGDALOID NUCLEUS; BRAIN LEVEL; BRAIN REGION; BREEDING; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DRINKING BEHAVIOR; DRUG POTENTIATION; EXPERIMENTAL ANIMAL; FOOD INTAKE; GENETIC MODEL; HUMAN; HUMAN GENETICS; HYPOTHALAMUS; KNOCKOUT MOUSE; MEDICAL RESEARCH; MOUSE MUTANT; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RODENT; SIGNAL TRANSDUCTION; SUGAR INTAKE;

EID: 0038275925     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(03)00109-4     Document Type: Conference Paper

References (56)

1. Badia-Elder N.E., Stewart R.B., Gilpin N.W., Elder R.L., Murphy J.M., Li T.K. Effects of neuropeptide Y (NPY) on ethanol-induced sleep time in alcohol-preferring (P) and -nonpreferring (NP) rats. Alcohol Clin. Exp. Res. 26:2002;99A.
2. Badia-Elder NE, Stewart RB, Powrozek TA, Murphy JM, Li TK, Effects of neuropeptide Y on sucrose and ethanol intake and on the elevated plus maze test of anxiety in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcohol Clin. Exp. Res. [in press].
3. Badia-Elder N.E., Stewart R.B., Powrozek T.A., Roy K.F., Murphy J.M., Li T.K. Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcohol Clin. Exp. Res. 25:2001;386-390.
4. Bice P., Foroud T., Bo R., Castelluccio P., Lumeng L., Li T.K.et al. Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Mamm. Genome. 9:1998;949-955.
5. Caberlotto L., Thorsell A., Rimondini R., Sommer W., Hyytia P., Heilig M. Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol Clin. Exp. Res. 25:2001;1564-1569.
6. Carr L.G., Foroud T., Bice P., Gobbett T., Ivashina J., Edenberg H.et al. A quantitative trait locus for alcohol consumption in selectively bred rat lines. Alcohol Clin. Exp. Res. 22:1998;884-887.
7. Cicero T.J. A critique of animal analogue of alcoholism. Majchrowichz E., Noble P. Biochemistry and pharmacology of ethanol. 1979;533-560 Plenum, New York.
8. Clark J.J., Karla P.S., Crowle W.R., Karla S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
9. Clark J.T., Keaton A.K., Sahu A., Kalra S.P., Mahajan S.C., Gudger J.N. Neuropeptide Y (NPY) levels in alcoholic and food restricted male rats: implications for site selective function. Regul. Pept. 75-76:1998;335-345.
10. Colmer W.F., Wahlestedt C. The biology of neuropeptide Y and related peptides. 1993;Humana Press, Totowa, NJ.
11. Dumont Y., Martel J.C., Fournier A., St. Pierre S., Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog. Neurobiol. 38:1992;125-167.
12. Ehlers C.L., Li T.K., Lumeng L., Hwang B.H., Somes C., Jimenez P.et al. Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure. Alcohol Clin. Exp. Res. 22:1998;1778-1782.
13. Ehlers C.L., Somes C., Cloutier D. Are some of the effects of ethanol mediated through NPY? Psychopharmacology. 139:1998;136-144.
14. Foroud T., Bice P., Castelluccio P., Bo R., Miller L., Ritchotte A.et al. Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines. Behav. Genet. 30:2000;131-140.
15. Heilig M., McLeod S., Brot M., Heinrichs S.C., Mensaghi F., Koob G.F.et al. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology. 8:1993;357-363.
16. Heilig M., Widerlov E. Neurobiology and clinical aspects of neuropeptide Y. Crit. Rev. Neurobiol. 9:1995;115-136.
17. Heyser C.J., Schulteis G., Durbin P., Koob G.F. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology. 18:1998;125-133.
18. Hwang B.H., Zhang J.K., Ehlers C.L., Lumeng L., Li T.K. Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. Alcohol Clin. Exp. Res. 23:1999;1023-1030.
19. Ilveskoski E., Kajander O.A., Kehtimaki T., Kannus T., Karhunen P.J., Heinala P.et al. Association of neuropeptide Y polymorphism with the occurrence of type 1 and type 2 alcoholism. Alcohol Clin. Exp. Res. 25:2001;1420-1422.
20. Kallio J., Pesonen U., Kaipio K., Karvonen M.K., Jaakkola U., Heinonen O.J.et al. Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans. FASEB J. 15:2001;1242-1244.
21. Karvonen M.K., Pesonen U., Koulu M., Niskanen L., Laakso M., Rissanen A.et al. Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat. Med. 4:1998;1434-1437.
22. Katner S.N., Slawecki C.J., Ehlers C.L. Neuropeptide Y administration into the amygdala does not effect ethanol consumption. Alcohol. 28:2002;29-38.
23. Katner S.N., Slawecki C.J., Ehlers C.L. Neuropeptide Y administration into the third ventricle does not increase sucrose or ethanol self-administration but does affect the cortical EEG and increases food intake. Psychopharmacology. 160:2002;146-154.
24. Kauhanen J., Karvonen M.K., Pesonen U., Koulu M., Tuomainen T.P., Uusitupa M.I.et al. Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am. J. Med. Genet. 93:2000;117-121.
25. Kelley S.P., Nannini M.A., Bratt A.M., Hodge C.W. Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration. Peptides. 22:2001;515-522.
26. Kinoshita H., Jessop D.S., Finn D.P., Coventry T.L., Roberts D.J., Ameno K.et al. Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus. NeuroReport. 11:2000;3517-3519.
27. Lappalainen J., Kranzler H.R., Malison R., Price L.H., Van Dyck C., Rosenheck R.A.et al. A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Arch. Gen. Psychiatry. 59:2002;825-831.
28. Levine A.S., Morley J.E. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides. 5:1984;1025-1029.
29. Marsh D.J., Baraban S.C., Hollopeter G., Palmiter R.D. Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc. Natl. Acad. Sci. U. S. A. 96:1999;13518-13523.
30. Mayfield R.D., Lewohl J.M., Dodd P.R., Herlihy A., Liu J., Harris R.A. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J. Neurochem. 81:2002;802-813.
31. Murphy J.M., Stewart R.B., Bell R.L., Badia-Elder N.E., Carr L.G., McBride W.J.et al. Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behav. Genet. 32:2002;363-388.
32. Naveilhan P., Canals J.M., Arenas E., Ernfors P. Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation. J. Neurochem. 78:2001;1201-1207.
33. Naveilhan P., Canals J.M., Valjakka A., Vartiainen J., Arenas E., Ernfors P. Neuropeptide Y alters sedation through a hypothalamic Y1-mediated mechanism. Eur. J. Neurosci. 13:2001;2241-2246.
34. Naveilhan P., Hassani H., Canals J.M., Ekstrand A.J., Larefalk A., Chhajlani V.et al. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat. Med. 5:1999;1188-1193.
35. Naveilhan P., Neveu I., Arenas E., Ernfors P. Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system. Neuroscience. 87:1998;289-302.
36. Okubo T., Harada S. Polymorphism of the neuropeptide Y gene: an association study with alcohol withdrawal. Alcohol Clin. Exp. Res. 25:2001;59S-62S.
37. Palmiter R.D., Erickson J.C., Hollopeter G., Baraban S.C., Schwartz M.W. Life without neuropeptide Y. Recent Prog. Horm. Res. 53:1998;163-199.
38. Pedrazzini T., Seydoux J., Kunstner P., Aubert J.F., Grouzmann E., Beermann F.et al. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat. Med. 4:1998;722-726.
39. Roy A., Pandey S.C. The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure. Alcohol Clin. Exp. Res. 26:2002;796-803.
40. Ryabinin A.E., Criado J.R., Henriksen S.J., Bloom F.E., Wilson M.C. Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of ethanol. Mol. Psychiatry. 2:1997;32-43.
41. Sinclair J.D. The feasibility of effective psychopharmacological treatments for alcoholism. Br. J. Addict. 82:1987;1213-1223.
42. Slawecki C.J., Betancourt M., Walpole T., Ehlers C.L. Increases in sucrose consumption, but not ethanol consumption, following ICV NPY administration. Pharmacol. Biochem. Behav. 66:2000;591-594.
43. Spanagel R., Holter S.M. Pharmacological validation of a new animal model of alcoholism. J. Neural Transm. 107:2000;669-680.
44. Spanagel R., Holter S.M., Allingham K., Landgraf R., Zieglgansberger W. Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur. J. Pharmacol. 305:1996;39-44.
45. Stanley B.G., Leibowitz S.F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U. S. A. 82:1985;3940-3943.
46. Thiele T.E., Cubero I., van Dijk G., Mediavilla C., Bernstein I.L. Ethanol-induced c-Fos expression in catecholamine- and neuropeptide Y-producing neurons in rat brainstem. Alcohol Clin. Exp. Res. 24:2000;802-809.
47. Thiele T.E., Koh M.T., Pedrazzini T. Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor. J. Neurosci. 22:2002;RC208.
48. Thiele T.E., Marsh D.J., Ste. Marie L., Bernstein I.L., Palmiter R.D. Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature. 396:1998;366-369.
49. Thiele T.E., Miura G.I., Marsh D.J., Bernstein I.L., Palmiter R.D. Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor. Pharmacol. Biochem. Behav. 67:2000;683-691.
50. Thiele T.E., Naveilhan P., Ernfors P. Mutant mice lacking the Y2 neuropeptide Y (NPY) receptor consume less ethanol than wild-type mice. Alcohol Clin. Exp. Res. 24:2000;97A.
51. Thorsell A., Rimondini R., Heilig M. Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Neurosci. Lett. 332:2002;1-4.
52. Woldbye D.P., Larsen P.J., Mikkelsen J.D., Klemp K., Madsen T.M., Bolwig T.G. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat. Med. 3:1997;761-764.
53. Woldbye D.P., Madsen T.M., Larsen P.J., Mikkelsen J.D., Bolwig T.G. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res. 737:1996;162-168.
54. Woldbye D.P.D., Ulrichsen J., Haugbol S., Bolwig T.G. Ethanol withdrawal in rats is attenuated by intracerebroventricular administration of neuropeptide Y. Alcohol Alcohol. 37:2002;318-321.
55. Yamada K., Shibasaki T., Tsumori C., Imaki T., Hotta M., Wakabayashi I.et al. Neuropeptide Y reverses corticotropin-releasing hormone- and psychological stress-caused shortening of sodium pentobarbital-induced sleep in rats. Brain Res. 725:1996;272-275.
56. Zhu G., Pollak L., Mottagui-Tabar S., Wahlestedt C., Taubman J., Vikkunen M.et al. NPY leu7pro and alcohol dependence in Finnish and Swedish populations. Alcohol Clin. Exp. Res. 27:2003;19-24.