dextro- and levo-morphine attenuate opioid δ and κ receptor agonist produced analgesia in μ-opioid receptor knockout mice

European Journal of Pharmacology

Volumn 531, Issue 1-3, 2006, Pages 103-107

  Wu, Hsiang En ^a   Sun, Han Sen ^a   Terashivili, Maia ^a   Schwasinger, Emma ^a   Sora, Ichiro ^b   Scott Hall, F ^c   Uhl, George R ^c   Tseng, Leon F ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Analgesia; Antianalgesia; Knockout mice; Opioid; Spinal cord

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DELTA OPIATE RECEPTOR AGONIST; DELTORPHIN; DELTORPHIN II; DEXTRO MORPHINE; KAPPA OPIATE RECEPTOR AGONIST; LEVO MORPHINE; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; HETEROZYGOSITY; HOMOZYGOSITY; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PAIN; PRIORITY JOURNAL; REACTION TIME; STRAIN DIFFERENCE; TAIL FLICK TEST; WILD TYPE;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS; ANALGESICS, OPIOID; ANIMALS; FEMALE; GENOTYPE; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHINE; NOCICEPTORS; OLIGOPEPTIDES; PAIN; PAIN MEASUREMENT; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM;

EID: 32044450280     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.012     Document Type: Article

References (14)

1. F.E. D'Amour, and D.L. Smith A method for determining loss of pain sensation J. Pharmacol. Exp. Ther. 72 1941 74 79
2. J.L.K. Hylden, and G.L. Wilcox Intrathecal morphine in mice: a new technique Eur. J. Pharmacol. 167 1980 313 316
3. I. Iijima, J-I. Minamikawa, A.E. Jacobsen, A. Brossi, and K.E. Rice Studies in the (+)-morphine series-5. Synthesis and biological properties of (+)-naloxone J. Med. Chem. 21 1978 398 400
4. Y.F. Jacquet, W.A. Klee, K.C. Rice, I. Iijima, and J. Minamikawa Stereospecfic and nonstereospecific effects of (+)-and (-)-morphine: evidence for a new class of receptors? Science 198 1977 842 845
5. H.H. Loh, H.S. Liu, A. Cavalli, W. Yang, Y.F. Chen, and L.N. Wei μ-opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality Mol. Brain Res. 54 1998 321 326
6. H.W.D. Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe, I. Kitchen, K. Befort, A. Dierich, M. Le Meur, P. Dolle, E. Tzavara, J. Hanoune, B.P. Roques, and B.L. Kieffer Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene Nature 383 1996 819 823
7. H.W.D. Matthes, C. Smadja, O. Valverde, J.L. Vonesch, A.S. Foutz, E. Boudinot, M. Denavit-Saubie, C. Severini, L. Negri, B.P. Roques, R. Maldonado, and B.L. Kieffer Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor J. Neurosci. 18 1998 7285 7295
8. H. Mizoguchi, M. Narita, D.E. Oji, C. Suganuma, H. Nagase, I. Sora, G.R. Uhl, E.Y. Cheng, and L.F. Tseng μ-Opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in μ-opioid receptor knockout mice Neuroscience 94 1999 203 207
9. S. Roy, H.C. Liu, and H.H. Loh Mu-opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit Brain Res. Mol. Brain Res. 56 1998 281 283
10. I. Sora, N. Takahashi, M. Funada, H. Ujike, R.S. Revay, D.M. Donovan, L.L. Miner, and G.R. Uhl Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive response and morphine-induced analgesia Proc. Natl. Acad. Sci. U. S. A. 94 1997 1544 1549
11. S.M. Sweitzer, P. Schubert, and J.A. DeLeo Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain J. Pharmacol. Exp. Ther. 297 2001 1210 1217
12. M. Tian, H.E. Broxmeyer, Y. Fan, Z. Lai, S. Zhang, S. Aronica, S. Cooper, R.M. Bigsby, R. Steinmetz, S.J. Engle, A. Mestek, J.D. Pollock, M.N. Lehman, H.T. Jansen, M. Ying, P.J. Stambrook, J.A. Tischfield, and L. Yu Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice J. Exp. Med. 185 1997 1517 1522
13. H. Wu, J. Thompson, H. Sun, R.J. Leitermann, J.M. Fujimoto, and L.F. Tseng Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord J. Pharmacol. Exp. Ther. 310 2004 240 246
14. H. Wu, J. Thompson, H. Sun, M. Terashvili, and L.F. Tseng Antianalgesia: stereo-selecitve action of dextro-morphine over levo-morphine on glia in the mouse spinal cord J. Pharmacol. Exp. Ther. 314 2005 1101 1108