Intraparenchymal injections of acid sphingomyelinase results in regional correction of lysosomal storage pathology in the Niemann-Pick A mouse

Experimental Neurology

Volumn 207, Issue 2, 2007, Pages 258-266

  Yang, Wendy W ^a   Dodge, James C ^a   Passini, Marco A ^a   Taksir, Tatyana V ^a   Griffiths, Denise ^a   Schuchman, Edward H ^b   Cheng, Seng H ^a   Shihabuddin, Lamya S ^a  

^a GENZYME CORPORATION   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Acid sphingomyelinase; Central nervous system; Glial activation; Intraparenchymal injection; Lysosomal storage diseases; Niemann Pick A disease

Indexed keywords

CHOLESTEROL; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOSIS; CELL INFILTRATION; CONTROLLED STUDY; DRUG DISTRIBUTION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LYSOSOME STORAGE DISEASE; MICROGLIA; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; RIGHT HEMISPHERE; THALAMUS;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; FILIPIN; LYSOSOMES; MICE; MICE, KNOCKOUT; NIEMANN-PICK DISEASE, TYPE A; SPHINGOMYELIN PHOSPHODIESTERASE; TIME FACTORS; TOXINS, BIOLOGICAL;

EID: 34548801983     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.06.017     Document Type: Article

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