Mycophenolic acid inhibits oleic acid-induced vascular smooth muscle cell activation by inhibiting cellular reactive oxygen species

Transplantation

Volumn 84, Issue 5, 2007, Pages 634-638

  Ahn, Hyung Joon ^a   Park, Jehyun ^a   Song, Jae Sook ^a   Ju, Man Ki ^a   Kim, Myoung Soo ^a   Ha, Hunjoo ^b   Song, Ki Ho ^c   Kim, Yu Seun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

Mycophenolic acid; Oleic acid; Proliferation; Reactive oxygen species; Vascular smooth muscle cells

Indexed keywords

ACETYLCYSTEINE; CYCLINE; DICHLOROFLUORESCEIN; FIBRONECTIN; MYCOPHENOLIC ACID; OLEIC ACID; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ACETYLCYSTEINE; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYTOPROTECTION; FIBRONECTINS; MUSCLE, SMOOTH, VASCULAR; MYCOPHENOLIC ACID; OLEIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 34548775197     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000278729.96633.6d     Document Type: Article

References (32)

1. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
2. Nankivell BJ, Chapman JR. Chronic allograft nephropathy: Current concepts and future directions. Transplantation 2006; 81: 643.
3. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
4. Allison AC. Immunosuppressive drugs: The first 50 years and a glance forward. Immunopharmacology 2000; 47: 63.
5. Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000; 47: 85.
6. Moon JI, Kim YS, Kim MS, et al. Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: In vitro study. Transplant Proc 2000; 32: 2026.
7. Bumgardner GL, Wilson GA, Tso PL, et al. Impact of serum lipids on long-term graft and patient survival after renal transplantation. Transplantation 1995; 60: 1418.
8. Aakhus S, Dahl K, Wideroe TE. Hyperlipidaemia in renal transplant patients. J Intern Med 1996; 239: 407.
9. Aakhus S, Dahl K, Wideroe TE. Cardiovascular morbidity and risk factors in renal transplant patients. Nephrol Dial Transplant 1999; 14: 648.
10. Roodnat JI, Mulder PG, Zietse R, et al. Cholesterol as an independent predictor of outcome after renal transplantation. Transplantation 2000; 69: 1704.
11. Wissing KM, Abramowicz D, Broeders N, Vereerstraeten P. Hypercholesterolemia is associated with increased kidney graft loss caused by chronic rejection in male patients with previous acute rejection. Transplantation 2000; 70: 464.
12. Fried LF, Orchard TJ, Kasiske BL. Effect of lipid reduction on the progression of renal disease: A meta-analysis. Kidney Int 2001; 59: 260.
13. Renard CB, Askari B, Suzuki LA, et al. Oleate, not ligands of the receptor for advanced glycation end-products, promotes proliferation of human arterial smooth muscle cells. Diabetologia 2003; 46: 1676.
14. Cullen P. Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol 2000; 86: 943.
15. Brynes AE, Edwards CM, Jadhav A, et al. Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. Am J Clin Nutr 2000; 72: 1111.
16. Seigneur M, Freyburger G, Gin H, et al. Serum fatty acid profiles in type I and type II diabetes: Metabolic alterations of fatty acids of the main serum lipids. Diabetes Res Clin Pract 1994; 23: 169.
17. Lu G, Meier KE, Jaffa AA, et al. Oleic acid and angiotensin II induce a synergistic mitogenic response in vascular smooth muscle cells. Hypertension 1998; 31: 978.
18. Kwok CF, Shih KC, Hwu CM, Ho LT. Linoleic acid and oleic acid increase the endothelin-1 binding and action in cultured rat aortic smooth muscle cells. Metabolism 2000; 49: 1386.
19. Askari B, Carroll MA, Capparelli M, et al. Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells. J Biol Chem 2002; 277: 36338.
20. Lu G, Greene EL, Nagai T, Egan BM. Reactive oxygen species are critical in the oleic acid-mediated mitogenic signaling pathway in vascular smooth muscle cells. Hypertension 1998; 32: 1003.
21. Greene EL, Lu G, Zhang D, Egan BM. Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Hypertension 2001; 37: 308.
22. Park J, Ha H, Seo J, et al. Mycophenolic acid inhibits platelet-derived growth factor-induced reactive oxygen species and mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Am J Transplant 2004; 4: 1982.
23. Ha H, Kim MS, Park J, et al. Mycophenolic acid inhibits mesangial cell activation through p38 MAPK inhibition. Life Sci 2006; 79: 1561.
24. Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004; 351: 2715.
25. Meier-Kriesche HU, Steffen BJ, Hochberg AM, et al. Long-term use of mycophenolate mofetil is associated with a reduction in the incidence and risk of late rejection. Am J Transplant 2003; 3: 68.
26. Allison AC, Eugui EM. Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs. Transplant Proc 1993; 25: 8.
27. Gregory CR, Pratt RE, Huie P, et al. Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. Transplant Proc 1993; 25: 770.
28. Raisanen-Sokolowski A, Vuoristo P, Myllarniemi M, et al. Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts. Transpl Immunol 1995; 3: 342.
29. Kharbanda SM, Sherman ML, Kufe DW. Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells. Blood 1990; 75: 583.
30. Vallee S, Fouchier F, Braguer D, et al. Ribavirin-induced resistance to heat shock, inhibition of the Ras-Raf-1 pathway and arrest in G(1). Eur J Pharmacol 2000; 404: 49.
31. Hauser IA, Renders L, Radeke HH, et al. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion. Nephrol Dial Transplant 1999; 14: 58.
32. Krotz F, Keller M, Derflinger S, et al. Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism. Hypertension 2007; 49: 201.