Ribavirin-induced resistance to heat shock, inhibition of the Ras-Raf-1 pathway and arrest in G1

European Journal of Pharmacology

Volumn 404, Issue 1-2, 2000, Pages 49-62

  Vallée, Sébastien ^a   Fouchier, Francis ^a   Braguer, Diane ^a   Marvaldi, Jacques ^a   Champion, Serge ^a  

^a UPRES A 6032 CNRS Fac P   (France)

Author keywords

Cell cycle; Extracellular signal regulated protein kinase; GTP; Heat shock; Raf 1; Ras; Ribavirin

Indexed keywords

GUANOSINE; GUANOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYPOXANTHINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OXIDOREDUCTASE; RAF PROTEIN; RAS PROTEIN; RIBAVIRIN; VINBLASTINE;

ARTICLE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HEAT SHOCK; HUMAN; HUMAN CELL; MICROTUBULE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIMETABOLITES; CELL DIVISION; CYTOSKELETON; FLOW CYTOMETRY; G1 PHASE; GUANOSINE TRIPHOSPHATE; HEAT; HEAT-SHOCK PROTEINS; HUMANS; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; RIBAVIRIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0034666560     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00596-3     Document Type: Article

References (82)

1. Ahn N.G., Seger R., Krebs E.G. The mitogen-activated protein kinase activator. Curr. Opin. Cell Biol. 4:1992;992-999.
2. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
3. Aublin J.L., Lambert B., Haye B., Jacquemin C., Champion S. Relationships between the GTP content and the TSH-stimulated adenylate cyclase activity of cultured thyroid cells. Mol. Cell. Endocrinol. 45:1986;11-20.
4. Avruch J., Zhang X.F., Kyriakis J.M. Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19:1994;279-283.
5. Barrau M.D., Blackburn G.R., Dewey W.C. Effect of heat on the centrosomes of Chinese hamster ovary cells. Cancer Res. 38:1978;2290-2294.
6. Best A., Ahmed S., Kozma R., Lim L. The Ras-related GTPase Rac-1 binds tubulin. J. Biol. Chem. 271:1996;3756-3762.
7. Bhalla K., Ibrado A.M., Tourkina E., Tang C., Maloney M.E., Huang Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia (Baltimore). 7:1993;563-568.
8. Birkenkamp K.U., Dokter W.H., Esselink M.T., Jonk L.J., Kruijer W., Vellenga E. A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation. Leukemia. 13:1999;1037-1045.
9. Brown R.E., Jarvis K.L., Hyland K.J. Protein measurement using bicinchoninic acid: elimination of interfering substances. Anal. Biochem. 180:1989;136-139.
10. Catapano C.V., Dayton J.S., Mitchell B.S., Fernandes D.J. GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Mol. Pharmacol. 47:1995;948-955.
11. Clark E.A., Hynes R.O. Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J. Biol. Chem. 271:1996;14814-14818.
12. Clevenger C.V., Thickman K., Ngo W., Chang W.P., Takayama S., Reed J.C. Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2. Mol. Endocrinol. 11:1997;608-618.
13. Cole C.N., Hammell C.M. Nucleocytoplasmic transport: driving and directing transport. Curr. Biol. 8:1998;R368-372.
14. Dahlberg J.E., Lund E. Functions of the GTPase Ran in RNA export from the nucleus. Curr. Opin. Cell. Biol. 10:1998;400-408.
15. Dasso M. The role of the Ran GTPase pathway in cell cycle control and interphase nuclear functions. Prog. Cell. Cycle Res. 1:1995;163-172.
16. Debec A. Inactivation fonctionnelle du centrosome de cellules 3T3 de souris par un choc thermique. C.R. Acad. Sci. Paris. 312:1991;683-687.
17. Dent P., Haser W., Haystead T.A., Vincent L.A., Roberts T.M., Sturgill T.W. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 Cells and in vitro. Science. 257:1992;1404-1407.
18. Dewhirst M.W. Hyperthermia in Cancer Therapy: Model Systems. 1990;Cold Spring Harbor Laboratory Press.
19. Donaldson K.L., Goolsby G., Kiener P.A., Wahl A.F. Activation of p34 cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ. 5:1994;1041-1050.
20. Drechel D.N., Kirschner M.W. The minimum GTP cap required to stabilize microtubules. Curr. Biol. 4:1994;1053-1061.
21. Fouchier F., Forget P., Bellan C., Marvaldi J., Champion S., Pichon J. The effects of Ribavirin on the GTP level and the VIP receptor dynamic of human IGR39 cells. J. Recept. Signal Transduction Res. 16:1996;39-58.
22. Fried J. Method for the quantitative evaluation of data from flow microfluorometry. Comp. Biomed. Res. 9:1976;263.
23. Garcia P., Braguer D., Carles G., El Khyari S., Barra Y., de Ines C., Barasoain I., Briand C. Comparative effects of taxol and taxotere on two different human carcinoma cell lines. Cancer Chemother. Pharmacol. 34:1994;335-343.
24. Hall A. The cellular functions of small GTP-binding proteins. Science. 249:1990;635-640.
25. Hall A. A biochemical Function for Ras-At last. Science. 264:1994;1413-1414.
26. Hancock J.F., Magee A.I., Childs J.E., Marshall C.J. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell. 57:1989;1167-1177.
27. Hancock J.F., Paterson H., Marshall C.J. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell. 63:1990;133-139.
28. Hata Y., Natsumeda Y., Weber G. Tiazofurin decreases Ras-GTP complex in K562 cells. Oncol. Res. 5:1993;161-164.
29. Hohfeld J., Jentsch S. GrpE-like regulation of the hc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16:1997;6209-6216. [published erratum appears in EMBO J. 1998. 17, 847].
30. Horwitz S.B. Mechanism of action of taxol. Trends Pharmacol. Sci. 13:1992;134-136.
31. Howe L.R., Leevers S.J., Gomez N., Nakielny S., Cohen P., Marshall C.J. Activation of the MAP Kinase pathway by the protein kinase raf. Cell. 71:1992;335-342.
32. Ilyin G.P., Langouet S., Rissel M., Delcros J.G., Guillouzo A., Guguen-Guillouzo C. Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes. Hepatology. 27:1998;1687-1694.
33. Jayaram H.N., Zhen W., Gharehbaghi K. Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells. Cancer Res. 53:1993;2344-2348.
34. Jayaram H.N., Cooney D.A., Grusch M. Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis. Curr. Med. Chem. 6:1999;561-574.
35. Johnson G.S., Mukku V.R. Evidence in intact cells for an involvement of GTP in the activation of Adenylate cyclase. J. Biol. Chem. 254:1979;95-100.
36. Kaziro Y., Itoh H., Kozasa T., Nakafuku M., Satoh T. Structure and function of signal-transducing GTP-binding proteins. Annu. Rev. Biochem. 60:1991;349-400.
37. Knight R.D., Mangum J., Lucas D.L., Cooney D.A., Khan E.C., Wright D.G. Inosine monophosphate dehydrogenase and myeloid cell maturation. Blood. 69:1987;634-639.
38. Koide H., Satoh T., Nakafuku M., Kaziro Y. GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 90:1993;8683-8686.
39. Kumar N. Taxol-induced polymerisation of purified tubulin. Mechanism of action. J. Biol. Chem. 256:1981;10435-10441.
40. Kyriakis J.M., App H., Zhang X.F., Barnerjee P., Brautigan D.L., Rapp U.R., Avruch J. RAF-1 Activates MAP kinase-kinase. Nature. 358:1992;417-421.
41. Lee J.C., Kassis S., Kumar S., Badger A., Adams J.L. p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. Pharmacol. Ther. 82:1999;389-397.
42. Leevers S.J., Paterson H.F., Marshall C.J. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature. 369:1994;411-414.
43. Li W., Shen F., Weber G. Ribavirin and Quercetin synergistically downregulate signal transduction and are cytotoxic in human ovarian carcinoma cells. Oncol. Res. 11:1999;243-247.
44. Liu J.J., Chao J.R., Jiang M.C., Ng S.V., Yen J.J., Yang-Yen H.F. Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol. Cell. Biol. 15:1995;3654-3663.
45. Liu Y., Bhalla K., Hill C., Priest D.G. Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line. Biochem. Pharmacol. 48:1994;1265-1272.
46. Luchetti F., Gregorini A., Papa S., Burattini S., Canonico B., Valentini M., Falcieri E. The K562 chronic myeloid leukemia cell line undergoes apoptosis in response to interferon-alpha. Haematologica. 83:1998;974-980.
47. Majumdar A., Kerby S., Mullikin B., Beckstead J.H., Stenberg P.E., Seidman M.M. IL-3 and Ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. J. Cell Physiol. 165:1995;530-537.
48. Malawista S.E., De Bois Fleury-Chevance A., Maunoury R., Bessis M. Heat as a probe of centrosomal function: a phase-contrast and immunofluorescent study of human blood monocytes. Blood Cells. 9:1983;443-453.
49. Marcaillou C., Debec A., Lauverjat S., Saihi A. The effect of the heat shock response on ultrastructure of the centrosome of Drosophila cultured cells in interphase: possible relation with changes in the chemical state of calcium. Biochem. Cell. Biol. 71:1993;507-517.
50. Marchesi V.T., Ngo N. In vitro assembly of multiprotein complexes containing α, β, and γ tubulin, heat shock protein HSP70, and elongation factor 1α Proc. Natl. Acad. Sci. U. S. A. 90:1993;3028-3032.
51. Melchior F., Gerace L. Two-way trafficking with Ran. Trends Cell. Biol. 8:1998;175-179.
52. Moodie S.A., Willumsen B.M., Weber M.J., Wolfman A. Complexes of Ras-GTP with Raf-1 and Mitogen-activated protein kinase kinase. Science. 260:1993;1658-1661.
53. Murray A., Hunt T. The Cell Cycle. 1993;Oxford Univ. Press.
54. Olah E., Natsumeda Y., Ikegami T., Kote Z., Horanyi M., Szelenyi J., Paulik E., Kremmer T., Hollan S.R., Sugar J., Weber G. Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells. Proc. Natl. Acad. Sci. U. S. A. 85:1988;6533-6537.
55. Olah E., Kote Z., Natsumeda Y., Yamaji Y., Jarai G., Lapis E., Financsek I., Weber G. Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells. Cancer Biochem. Biophys. 11:1990;107-117.
56. Olah E., Csokay B., Prajda N., Kote-Jarai Z., Yeh Y.A., Weber G. Molecular mechanisms in the antiproliferative action of taxol and tiazofurin. Anticancer Res. 16:1996;2469-2477.
57. Peavy D.L., Koff W.C., Hyman D.S., Knight V. Inhibition of lymphocyte proliferative responses by ribavirin. Infect. Immunol. 29:1980;583-589.
58. Potter C.W., Phair J.P., Vodinelich L., Fenton R., Jennings R. Antiviral, immunosuppressive and antitumour effects of Ribavirin. Nature. 259:1976;496-497.
59. Reed J.C., Miyashita T., Takayama S., Wang H.G., Sato T., Krajewski S., Aime-Sempe C., Bodrug S., Kitada S., Hanada M. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem. 60:1996;23-32.
60. Rowinsky E.K., Donehower R.C. The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics. Pharmacol. Ther. 52:1991;35-84.
61. Satoh T., Nakafuku M., Kaziro Y. Function of Ras as a molecular switch in signal transduction. J. Biol. Chem. 267:1992;24149-24152.
62. Schiff P.B., Horwitz S.B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. U. S. A. 77:1980;1561-1565.
63. Schulte T.W., BLagosklonny M.V., Ingui C., Neckers L. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association. J. Biol. Chem. 270:1995;24585-24588.
64. Stokoe D., MacDonald S.G., Cadwallader K., Symons M., Hancock J.F. Activation of Raf as a result of recruitment to the plasma membrane. Science. 264:1994;1463-1467.
65. Streeter D.G., Witkowski J.T., Khare G.P., Sidwell R.W., Bauer R.J., Robbins R.K., Simon L.N. Mechanism of action of 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc. Natl. Acad. Sci. U. S. A. 70:1973;1174-1178.
66. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J.A., Reed J.C. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 80:1995;279-284.
67. Takayama S., Bimston D.N., Matsuzawa S., Freeman B.C., Aime-Sempe C., Xie Z., Morimoto R.I., Reed J.C. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 16:1997;4887-4896.
68. Thomas S.M., DeMarco M., D'Arcangelo G., Halegoua S., Brugge J.S. Ras is essential for nerve growth factor and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell. 68:1992;1031-1040.
69. Tricot G., Jayaram H.N., Weber G., Hoffman R. Tiazofurin: biological effects and clinical uses. Int. J. Cell Cloning. 8:1990;161-170.
70. Van Aelst L., Barr M., Marcus S., Polverino A., Wigler M. Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. U. S. A. 90:1993;6213-6217.
71. Vojtek A.B., Hollenberg S.M., Cooper J.A. Mammalian Ras interacts directly with the serine/treonine kinase Raf. Cell. 74:1993;205-214.
72. Wang H.G., Reed J.C. Bcl-2, Raf-1 and mitochondrial regulation of apoptosis. Biofactors. 8:1998;13-16.
73. Wang H.G., Takayama S., Rapp U.R., Reed J.C. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. U. S. A. 93:1996;7063-7068.
74. Warne P.H., Viciana P.R., Downward J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature. 364:1993;352-355.
75. Wartmann M., Davis R.J. The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex. J. Biol. Chem. 269:1994;6695-6701.
76. Weber G., Nagai M., Natsumeda Y., Eble J.N., Jayaram H.N., Paulik E., Zhen W.N., Hoffman R., Tricot G. Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient. Cancer Commun. 3:1991;61-66.
77. Weber G., Hata Y., Prajda N. Role of differenciation induction in action of purine antimetabolites. Pharm. World Sci. 16:1994;77-83.
78. Weber G., Shen F., Yang H., Prajda N., Li W. Amplification of signal transduction capacity and down-regulation by drugs. Adv. Enzyme Regul. 39:1999;51-66.
79. Wood K.W., Sarnecki C., Roberts T.M., Blenis J. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell. 68:1992;1041-1050.
80. Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 80:1995;285-291.
81. Zerial M., Stenmark H. Rab GTPases in vesicular transport. Curr. Opin. Cell Biol. 5:1993;613-620.
82. Zhang X.F., Settleman J., Kyriakis J.M., Takeuchi-Suzuki E., Elledge S.J., Marshall M.S., Bruder J.T., Rapp U.R., Avruch J. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-raf-1. Nature. 364:1993;308-313.